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Chain-modified radioiodinated fatty acids

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Noninvasive Imaging of Cardiac Metabolism

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 55))

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Abstract

Myocardial perfusion has been experimentally and clinically evaluated by intravenously administered gamma-emitting radiopharmaceuticals such as thallium-201 (201Tl). Evaluation of myocardial metabolism using radiopharmaceuticals as an alternative to and/or a complement of perfusion is desirable. Metabolic studies could have clinical applications in early detection of heart disease and serial monitoring of the effects of therapy. Since fatty acids constitute the major energy source of heart tissue through β-oxidation catabolism and since they are efficiently extracted from the blood by the heart, efforts have been made to radiolabel these acids and to evaluate them in normal and damaged heart tissue. Although the myocardium extracts and metabolizes both odd and even numbered carbon chain lengths as well as both saturated and unsaturated fatty acids, the acids primarily metabolized are the 16-carbon saturated palmitic acid (x=14 in the formula below), the 18-carbon saturated stearic acid (x=16) and the 18-carbon unsaturated oleic acid (x=y=7).

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Authors
  1. C. A. Otto
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Editors and Affiliations

  1. Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA

    E. E. van der Wall

  2. Department of Cardiology, Leiden University, The Netherlands

    E. E. van der Wall

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Otto, C.A. (1987). Chain-modified radioiodinated fatty acids. In: van der Wall, E.E. (eds) Noninvasive Imaging of Cardiac Metabolism. Developments in Cardiovascular Medicine, vol 55. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3287-6_3

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  • DOI: https://doi.org/10.1007/978-94-009-3287-6_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7976-1

  • Online ISBN: 978-94-009-3287-6

  • eBook Packages: Springer Book Archive

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