Abstract
Between 1962 and 1988 we have experienced at the National Cancer Center Hospital 55 cases of familial adenomatous polyposis(FAP) of the colon involving 29 families (43 males, 12 females). The prognosis of the various accompanying FAP tumors were as follows: 1) Benign tumors originated from ectodermal, mesodermal and endodermal tissue had already developed during early childhood and had increased in size and number by puberty, though it was suspected that the tumor growth had generally stopped from that time onwards; 2) Mandibular osteomas developed near the roots of the permanent teeth after the eruption and loss of the deciduous teeth, suggesting that the abnormal repair of the osseous damage plays a great role in mandibular tumorigenesis. 3) Malignant tumors were seen to develop in the glandular epithelium that originated from the endodermal tissue, such as the colon, the small intestine, the stomach, and the thyroid. C Key words: Familial adenomatous polyposis; Associated lesion; Natural history; Mandibular osteoma]
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Burt W, Berenson MM, Lee RG et al (1984): Upper gastrointestinal polyps in Gardner’s syndrome. Gastroenterology 86: 295–301
Bussey HJR, Veale AMO, Morson BC (1978): Genetics of gastrointestinal polyposis. Gastroenterology 74: 1325–1330
Gardner EJ (1951): A genetic and clinical study of intestinal polyposis: A predisposing factor for carcinoma of the colon and rectum. Am J Hum Genet 3: 167–176
Gardner EJ, Plenk HP (1952): Hereditary pattern for multiple osteoma in a family group. Am J Hum Genet 4: 31–36
Jarvinen H, Nyberg M, Peltokallio P (1983): Upper gastrointestinal tract polyps in familial adenomatosis coli. Gut 24: 333–339
Ohsato K, Watanabe H, Yao T (1974): Simultaneous occurrence of multiple gastric carcinoma and familial polyposis of the colon. Jpn J Surg 4: 165–174
Pauli RM, Pauli ME, Hall JG (1980): Gardner syndrome and periampullary malignancy. Am J Med Genet 6: 205–219
Ranzi T, Castagnone D, Velio P, Bianchi P, Polli EE (1981): Gastric and duodenal polyps in familial polyposis coli. Gut 22: 363–367
Smith WG (1958): Multiple polyposis, Gardner’s syndrome, and desmoid tumors. Dis Colon Rectum 1: 323–332
Ushio K, Sasagawa M, Doi H, Yamada T, Ichikawa H, Hojo K, Koyama Y, Sano R (1976): Lesions associated with familial polyposis coli; Studies of the stomach, duodenum, bones and teeth. Gastrointest Radiol 1: 67–80
Ushio K (1985): Genetic and familial factors in colorectal cancer. Jpn J Clin Oncol 15(Suppl 1): 281–298
Utsunomiya J, Maki T, Iwama T, Matsunaga Y, Ichikawa T, Shimomura T, Hamaguchi E, Aoki N (1974): Gastric lesions of familial polyposis of the large intestine. Cancer 34: 745–754
Utsunomiya J, Nakamura T (1975): The occult osteomatous changes in the mandible in patient with familial polyposis coli. Br J Surg 62: 45–51
Yao T, Iida M, Ohsato K, Watanabe H, Omae T (1977): Duodenal lesions in familial polyposis of the colon. Gastroenterology 73: 1086–1092
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Japan
About this paper
Cite this paper
Ushio, K. (1990). Follow-up Study of Associated Tumors in Cases of Familial Adenomatous Polyposis. In: Utsunomiya, J., Lynch, H.T. (eds) Hereditary Colorectal Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68337-7_12
Download citation
DOI: https://doi.org/10.1007/978-4-431-68337-7_12
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68339-1
Online ISBN: 978-4-431-68337-7
eBook Packages: Springer Book Archive