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Combined Use of Drugs and Radiation in the Treatment of Liver Metastases

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Therapeutic Strategies in Primary and Metastatic Liver Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 100))

Abstract

The liver presents a unique opportunity to study the potential benefits of drug and X-ray combinations in a complete organ system. The entire liver can be radiated without delivering an excessive dose to nearby organ systems since they are either less radiosensitive (gut) or can be screened or even partially sacrificed (kidney). On the other hand the liver itself is extremely radiosensitive and cannot tolerate the dose of radiation required to sterilize other than subclinical epithelial tumor burdens. This chapter is devoted to a survey of means by which radiation and drugs can be combined in order to overcome this severe limitation. Recently developed techniques which promise a more quantitative evaluation of drug X-ray interactions as they affect hepatocyte survival are also included.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Daniel Freeman Memorial Hospital, 333 North Prairie Avenue, Inglewood, CA, 90301, USA

    J. E. Byfield

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  1. J. E. Byfield
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Editor information

Editors and Affiliations

  1. Chirurgische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 110, 6900, Heidelberg 1, Germany

    Christian Herfarth , Peter Schlag  & Peter Hohenberger ,  & 

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© 1986 Springer-Verlag Berlin · Heidelberg

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Byfield, J.E. (1986). Combined Use of Drugs and Radiation in the Treatment of Liver Metastases. In: Herfarth, C., Schlag, P., Hohenberger, P. (eds) Therapeutic Strategies in Primary and Metastatic Liver Cancer. Recent Results in Cancer Research, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82635-1_37

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  • DOI: https://doi.org/10.1007/978-3-642-82635-1_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82637-5

  • Online ISBN: 978-3-642-82635-1

  • eBook Packages: Springer Book Archive

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