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Alterations in Kinetic Parameters Resulting in Modification of Toxicity

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Use of Mechanistic Information in Risk Assessment

Part of the book series: Archives of Toxicology, Supplement 16 ((TOXICOLOGY,volume 16))

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Abstract

Pharmacokinetic measurements are now routinely integrated within toxicity studies as a means of providing information on drug availability and dose response across test species exposed to different dosage regimens for various periods of treatment (Smith et al, 1990). The quantification of plasma concentrations and areas under plasma concentration against time curves (AUC) has proved very useful to identify changes in toxicity linked to formulation, absorption variability, sex- or dose-dependent kinetics, and induction or inhibition of metabolizing enzymes.

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Author information

Authors and Affiliations

  1. Centre de Recherche, Pfizer, BP 159, F-37401, Amboise CĂ©dex, France

    C. Charuel

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  1. C. Charuel
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Editor information

Editors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Hermann M. Bolt

  2. Department of Occupational Medicine, Uppsala University Hospital, S-75185, Uppsala, Sweden

    Björn Hellman

  3. Department of Pharmaceutical Biosciences: Toxicology, BMC, Uppsala University, Box 594, S-75124, Uppsala, Sweden

    Lennart Dencker

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© 1994 Springer-Verlag Berlin Heidelberg

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Charuel, C. (1994). Alterations in Kinetic Parameters Resulting in Modification of Toxicity. In: Bolt, H.M., Hellman, B., Dencker, L. (eds) Use of Mechanistic Information in Risk Assessment. Archives of Toxicology, Supplement 16, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78640-2_27

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  • DOI: https://doi.org/10.1007/978-3-642-78640-2_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78642-6

  • Online ISBN: 978-3-642-78640-2

  • eBook Packages: Springer Book Archive

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