Abstract
Receptors which recognize cholecystokinin (CCK) peptides are particularly interesting and notable, both for their similarities and for their differences. There appear to be a family of such receptors which will likely be homologous, yet possess exquisite differences in their structural specficities.
This work was supported by grants from the National Institutes of Health (DK32878 and DK34988) and the Chadwick Foundation
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Barrett RW, Steffey ME, Wolfram CA (1989) Type-A cholecystokinin receptors in CHP212 neuroblastoma cells: evidence for association with G protein and activation of phosphoinositide hydrolysis. Mol Pharmacol 35:394–400
Chang RS, Chen TB, Bock MG, Freidinger RM, Chen R, Rosegay A, Lotti VJ (1989) Characterization of the binding of [3H]L-365260: a new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand. Mol Pharmacol 35:803–808
Durieux C, Corringer PJ, Bergeron F, Roques BP (1989) [3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors. Eur J Pharmacol 168:269–270
Fourmy D, Lopez P, Poirot S, Jimenez J, Dufresne M, Moroder L, Powers SP, Vaysse N (1989) A new probe for affinity labelling pancreatic cholecystokinin receptor with minor modification of its structure. Eur J Biochem 185:397–403
Freidinger RM (1989) Cholecystokinin and gastrin antagonists. Med Res Rev 9:271–290
Gaisano HY, Klueppelberg UG, Pinon DI, Pfenning MA, Powers SP, Miller LJ (1989) Novel tool for the study of cholecystokinin-stimulated pancreatic enzyme secretion. J Clin Invest 83:321–325
Hruby VJ, Fang S, Knapp R, Kazmierski W, Lui GK, Yamamura HI (1990) Cholecystokinin analogs with high affinity and selectivity for brain versus peripheral membrane receptors. In: Rivier JE, Marshall GR (eds) Peptides: chemistry, structure and biology. ESCOM, Leiden, pp 53–55
Jensen RT, Wank SA, Rowley WH, Sato S, Gardner JD (1989) Interaction of CCK with pancreatic acinar cells. Trends Pharmacol Sci 10:418–423
Klueppelberg UG, Gaisano HY, Powers SP, Miller LJ (1989) Use of a nitrotryptophan-containing peptide for photoaffinity labeling the pancreatic cholecystokinin receptor. Biochemistry 28:3463–3468
Klueppelberg UG, Powers SP, Miller LJ (1989) Protease peptide mapping of affinity-labeled rat pancreatic cholecystokinin-binding proteins. Biochemistry 28:7124–7129
Klueppelberg UG, Molero X, Barrett RW, Miller LJ (1990) Biochemical characterization of the cholecystokinin receptor on CHP212 human neuroblastoma cells. Mol Pharmacol (in press)
Lin CW, Holladay MW, Witte DG, Miller TR, Wolfram CAW, Bianchi BR, Bennett MJ, Nadzan AM (1990) A71378: CCK agonist with high potency and selectivity for CCK- A receptors. Am J Physiol 258:G648–G651
Lotti VJ, Chang RS (1989) A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365260. Eur J Pharmacol 162:273–280
Madison LD, Rosenzweig SA, Jamieson JD (1984) Use of the heterobifunctional cross-linker m-maleimidobenzoyl N-hydroxysuccinimide ester to affinity label cholecystokinin binding proteins on rat pancreatic plasma membranes. J Biol Chem 259:14818–14823
Maton PN, Jensen RT, Gardner JD (1986) Cholecystokinin antagonists. Horm Metab Res 18:2–9
Menozzi D, Gardner JD, Jensen RT, Maton PN (1989) Properties of receptors for gastrin and CCK on gastric smooth muscle cells. Am J Physiol 257:G73–G79
Miller LJ (1984) Characterization of cholecystokinin receptors on human gastric smooth muscle tumors. Am J Physiol 247:G402–G410
Parsons WH, Patchett AA, Holloway MK, Smith GM, Davidson JL, Lotti VJ, Chang RSL (1989) Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted benzolactams. J Med Chem 32:1681–1685
Pearson RK, Miller LJ (1987) Affinity labeling of a novel cholecystokininbinding protein in rat pancreatic plasmalemma using new short probes for the receptor. J Biol Chem 262:869–876
Pearson RK, Miller LJ, Hadac EM, Powers SP (1987) Analysis of the carbohydrate composition of the pancreatic plasmalemmal glycoprotein affinity labeled by short probes for the cholecystokinin receptor. J Biol Chem 262: 13850–13856
Pearson RK, Miller LJ, Powers SP, Hadac EM (1987) Biochemical characterization of the pancreatic cholecystokinin receptor using monofunctional photo-activatable probes. Pancreas 2:79–84
Pearson RK, Powers SP, Hadac EM, Gaisano H, Miller LJ (1987) Establishment of a new short, protease-resistant, affinity labeling reagent for the cholecystokinin receptor. Biochem Biophys Res Commun 147:346–353
Peikin SR, Costenbader CL, Gardner JD (1979) Actions of derivatives of cyclic nucleotides on dispersed acini from guinea pig pancreas. Discovery of a competitive antagonist of the action of cholecystokinin. J Biol Chem 254: 5321–5327
Powers SP, Fourmy D, Gaisano H, Miller LJ (1988) Intrinsic photoaffinity labeling probes for cholecystokinin (CCK)-gastrin family receptors D-Tyr-Gly-[Nle28,31,pNO2-Phe33)CCK-26–33). J Biol Chem 263:5295–5300
Rodriguez M, Lignon MF, Galas MC, Amblard M, Martinez J (1990) Highly selective cyclic cholecystokinin analogs for central receptors. In: Rivier JE, Marshall GR (eds) Peptides: chemistry, structure and biology. ESCOM, Leiden, pp 108–110
Rosenzweig SA, Miller LJ, Jamieson JD (1983) Identification and localization of cholecystokinin-binding sites on rat pancreatic plasma membranes and acinar cells: a biochemical and autoradiographic study. J Cell Biol 96:1288–1297
Rosenzweig SA, Madison LD, Jamieson JD (1984) Analysis of cholecystokininbinding proteins using endo-beta-N-acetylglucosaminidase F. J Cell Biol 99: 1110–1116
Roy P, Charpentier B, Durieux C, Dor A, Roques BP (1990) Conformational behavior of cyclic CCK-related peptides determined by 400-MHz 1H-NMR: relationships with affinity and selectivity for brain receptors. Biopolymers 28: 69–79
Sakamoto C, Goldfine ID, Williams JA (1984) Pancreatic CCK receptors: characterization of covalently labeled subunits. Biochem Biophys Res Commun 118:623–628
Schjoldager B, Molero X, Miller LJ (1989) Functional and biochemical characterization of the human gallbladder muscularis cholecystokinin receptor. Gastroenterology 96:1119–1125
Schjoldager B, Molero X, Miller LJ (1990) Gallbladder CCK receptors: species differences in glycosylation of similar protein cores. Regul Pept 28:265–272
Shaw MJ, Hadac EM, Miller LJ (1987) Preparation of enriched plasma membranes from bovine gallbladder muscularis for characterization of cholecystokinin receptors. J Biol Chem 262:14313–14318
Svoboda M, Lambert M, Furnelle J, Christophe J (1982) Specific photoaffinity crosslinking of [125I]cholecystokinin to pancreatic plasma membranes. Evidence for a disulfide-linked Mr 76000 peptide in cholecystokinin receptors. Regul Pept 4:163–172
Yu D-H, Huang SC, Wank SA, Mantey S, Gardner JD, Jensen RT (1990) Pancreatic receptors for cholecystokinin: evidence fot three receptor classes. Am J Physiol 258:G86–G95
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Miller, L.J. (1991). Heterogeneity of CCK Receptors: Classification and Characterization. In: Adler, G., Beglinger, C. (eds) Cholecystokinin Antagonists in Gastroenterology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76362-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-76362-5_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76364-9
Online ISBN: 978-3-642-76362-5
eBook Packages: Springer Book Archive