Skip to main content
SpringerLink
Log in

Cytostatic Therapy of Chronic Myelogenous Leukemia: Review and Perspectives

  • Conference paper
Chronic Myelocytic Leukemia and Interferon

Abstract

There is general agreement that life expectancy of patients with chronic myelogenous leukemia (CML) has not changed much during the past 60 years [15, 20, 28, 35, 41]. CML has remained uniformly fatal, and the only curative therapy available up to now has been bone marrow transplantation [16, 58]. This, however, can be offered only to the small proportion of CML patients of sufficiently young age who have an HLA-compatible donor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allan NC, Duvall E, Stockdill G (1978) Combination chemotherapy for chronic granulocytic leukemia. Lance 2: 523

    Article  CAS  Google Scholar 

  2. Baccarani M, Corbelli G, Tura S, and the Italian Cooperative Study Group on Chronic Myeloid Leukemia (1981) Early splenectomy and polychemotherapy versus polychemotherapy alone in chronic myeloid leukemia. Leuk Res 5: 149–157

    Article  PubMed  CAS  Google Scholar 

  3. Bolin RW, Robinson WA, Sutherland J, Hamman RF (1982) Busulfan versus hydroxyurea in long-term therapy of chronic myelogenous leukemia, Cancer 50: 1683–1687

    Article  PubMed  CAS  Google Scholar 

  4. Brodsky I, Fuscaldo KE, Kahn SB, Conroy JF (1979) Myeloproliferative disorders. II. CML: Clonal evolution and its role in management. Leuk Res 3: 379–393

    Article  PubMed  CAS  Google Scholar 

  5. Canellos GP, DeVita VT, Whang Peng J, Carbone PP (1971) Hematology and cytogenetic remission of blastic transformation in chronic granulocytic leukemia. Blood 38: 671–679

    PubMed  CAS  Google Scholar 

  6. Canellos GP, Young RC, Niemann PE, DeVita VT Jr (1975) Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan. Blood 45: 197–203

    PubMed  CAS  Google Scholar 

  7. Canellos GP, DeVita VT, Whang-Peng J, Chabner BA, Schein PS, Young RC (1976) Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy. Blood 47: 1003–9

    PubMed  CAS  Google Scholar 

  8. Canellos GP (1977) The treatment of chronic granulocytic leukaemia. Clin Haemotol 6: 113–128

    CAS  Google Scholar 

  9. Coleman M, Silver R, Pajak T, Cavalli F, Rai KR, Kostin JE, Glidewell O, Holland JF (1980) Combination chemotherapy for terminal-phase chronic granulocytic leukemia: cancer and leukemia group B studies. Blood 55: 29–36

    PubMed  CAS  Google Scholar 

  10. Conrad CFG (1973) Survival in chronic granulocytic leukemia: splenic irradiation vs. busulfan. Arch Intern Med 131: 684–685

    Article  PubMed  CAS  Google Scholar 

  11. Cunningham I, Gee T, Dowling M et al. (1979) Results of treatment of Ph1-!- chronic myelogen¬ous leukemia with an intensive treatment regimen (L-5 protocol). Blood 53: 375–395

    PubMed  CAS  Google Scholar 

  12. Dibromomannitol Cooperative Study Group (1973) Survival of chronic myeloid leukaemia patients treated by dibromomannitol. Eur J Cancer Clin Oncol 9: 583–589

    Google Scholar 

  13. Donehower RC (1982) Hydroxyurea. In: Chabner B (ed) Pharmacologic principles of cancer treatment. Saunders, Philadelphia, pp 269–275

    Google Scholar 

  14. Foley HT, Bennett JM, Carbone PP (1969) Combination chemotherapy in accelerated phase of chronic granulocytic leukemia. Arch Intern Med 123: 166–170

    Article  PubMed  CAS  Google Scholar 

  15. Goldman JM (1978) Modern approaches to the management of chronic granulocytic leukemia. Semin Hematol 15: 420–430

    PubMed  CAS  Google Scholar 

  16. Goldmann JM, Apperley JF, Jones L et al. (1986) Bone marrow transplantation for patients with chronic myeloid leukemia. N Engl J Med 314: 202–206

    Article  Google Scholar 

  17. Gollerkeri MP, Shah GB (1971) Management of chronic myeloid leukemia: a five year survey with a comparison of oral busulfan and splenic irradiation. Cancer 27: 596–601

    Article  PubMed  CAS  Google Scholar 

  18. Goto T, Nishikori M, Arlin Z, Gee T, Kempin S, Burchenal J, Strife A, Wisniewski D, Lambek C, Little C, Jhanwar S, Chaganti R, Clarkson B (1982) Growth Characteristics of leukemic and normal hematopoietic cells in Ph, chronic myelogenous leukemia and effects of intensive treatment. Blood 59: 793–808

    PubMed  CAS  Google Scholar 

  19. Griffin JD, Todd RF III, Ritz J, Nadier LM, Canellos GP, Rosenthal D, Gallivan M, Beveridge RP, Weinstein H, Karp D, Schlossman SF (1983) Differentiation patterns in the blastic phase of chronic myeloid leukemia. Blood 61: 85–91

    PubMed  CAS  Google Scholar 

  20. Griffin JD (1986) Management of chronic myelogenous leukemia. Semin Hematol 23 [Suppl 1]: 20–26

    PubMed  CAS  Google Scholar 

  21. Hadlock DC, Fortuny IE, McCullough J, Kennedy BJ (1975) Continuous flow centrifuge leukapheresis in the management of chronic myelogenous leukaemia. Br J Haematol 29: 443–453

    Article  PubMed  CAS  Google Scholar 

  22. Hauch T, Logue G, Laszlo J, Cox E, Rundles W (1978) Treatment of chronic granulocytic leukemia with melphalan. Blood 51: 571–577

    PubMed  CAS  Google Scholar 

  23. Haut A, Abbott WS, Wintrobe MM, Cartwright GE (1961) Busulfan in the treatment of chronic myelocytic leukemia: the effect of long term intermittent therapy. Blood 17: 1–19

    PubMed  CAS  Google Scholar 

  24. Hayes D, Ellison R, Glidewell O, Holland J, Silver R (1974) Chemotherapy for the terminal phase of chronic myelocytic leukemia. Cancer Chemother Rep 58: 233–247

    Google Scholar 

  25. Hehlmann R, Heimpel H, Hossfeld DK, Kopeke W, Kolb HJ, Löffler H, Pralle H, Queißer W, Anger B, Bergmann L, Zankovich R, Meyer P, Essers U, Siegert W, Vaupel HA, Heiss F, Messerer D, Hasford J, Carbonell F, Heinze B, Burkhardt R, Georgii A (1987) Prospektive kontrollierte Studie zur Therapie der chronischen myeloischen Leukämie (CML). Onkologie 10: 28–33

    Article  PubMed  CAS  Google Scholar 

  26. Hellriegel KP (1981) Therapie der Blastenkrise der chronischen myeloischen Leukämie. Ergeb¬nisse einer Phase-II-Studie mit Vindesin. Folia Haematol (Leipz) 108: 699–706

    CAS  Google Scholar 

  27. Hester JP, Waddell CC, Coltmann CA, Morrison FS, Stephens RL, Balcerzak SP, Baker LH, Timothy Chen T (1984) Response of chronic myelogenous leukemia patients to COAP-splenectomy. Cancer 54: 1977–1982

    Article  PubMed  CAS  Google Scholar 

  28. Hossfeld DK, Cohnen G (1978) Die chronische myeloische Leukämie. In: Begemann H (ed) Leukämien. Springer, Berlin Heidelberg New York, pp 443–518 (Handbuch der Inneren Medi-zin, vol 2, part 6 )

    Google Scholar 

  29. Ihde DC, Canellos GP, Schwartz JH, DeVita VT (1976) Splenectomy in the chronic phase of chronic granulocytic leukemia. Ann Intern Med 84: 17–21

    PubMed  CAS  Google Scholar 

  30. Janossy G, Woodruff RK, Pippard MJ et al. (1979) Relation of “lymphoid” phenotype and response to chemotherapy incorporating vincristine and prednisone in the acute phase of Ph1 positive leukemia. Cancer 43: 426–434

    Article  PubMed  CAS  Google Scholar 

  31. Kantarjian HM, Velekoop L, McCredie KB, et al. (1985) Intensive combination chemotherapy (ROAP10) and spenectomy in the management of chronic myelogenous leukemia J Clin Oncol 3: 192–200

    PubMed  CAS  Google Scholar 

  32. Kantarjian HM, Smith TL, McCredie KB, Keating MJ, Walters R, Talpaz M, Hester JP, Bligham G, Gehan E, Freireich EJ (1985) Chronic myelogenous leukemia: a multivariate analysis of the associations of patient characteristics and therapy with survival. Blood 66: 1326–1335

    PubMed  CAS  Google Scholar 

  33. Kaung DT, Close HP, Whittington RM, Patno ME (1971) Comparison of Busulfan and cyclophosphamide in the treatment of chronic myelocytic leukemia. Cancer 27: 608–612

    Article  PubMed  CAS  Google Scholar 

  34. Kennedy BJ (1972) Hydroxyurea therapy in chronic myelogenous leukemia. Cancer 29: 1052–1056

    Article  PubMed  CAS  Google Scholar 

  35. Koeffler HP, Golde DW (1981) Chronic myelogenous leukemia — new concepts. N. Engl J Med 304: 1201–1209 and 1269–1274

    Google Scholar 

  36. Koller A, Miller DM (1986) Preliminary observations on the therapy of the myeloid blast phase of chronic granulocytic leukemia with plicamycin and hydroxyurea. N Engl J Med 315: 1433–1438

    Article  PubMed  CAS  Google Scholar 

  37. Marks SM, Baltimore D, McCaffrey R (1978) Terminal transferase as a predictor of initial responsiveness to vincristine and prednisone in blastic crisis of myelogenous leukemia: a co-operative study. N Engl J Med 298: 812–4

    Article  PubMed  CAS  Google Scholar 

  38. Marmont AM, Damasio EE (1973) The treatment of terminal metamorphosis of chronic granulocytic leukaemia with corticosteroids and vincristine. Acta Haematol 50: 1–8

    Article  PubMed  CAS  Google Scholar 

  39. Medical Research Council’s Working Party for Therapeutic Trials in Leukemia (1968) Chronic granulocytic leukemia: comparison of radiotherapy and busulfan therapy. Br Med J [Clin Res] 1: 201–208

    Article  Google Scholar 

  40. Medical Research Council’s Working Party for Therapeutic Trials in Leukemia (1983) Randomized trial of splenectomy in Ph1-positive chronic granulocytic leukaemia, including an analysis of prognostic features. Br J Haematol 54: 415–430

    Article  Google Scholar 

  41. Minot GR, Buckman TE, Isaacs R (1924) Chronic myelogenous leukemia, age, incidence, duration and benefit derived from treatment. JAMA 82: 1489

    Google Scholar 

  42. Musshoff K, Boutis L, Obrecht P, Karsch T (1969) Die Lebenserwartung der chronischen myeloischen Leukämie in Abhängigkeit von individuellen und krankheitsspezifischen Faktoren und der Therapie. Klin Wochenschr 47: 179–183

    Article  PubMed  CAS  Google Scholar 

  43. Niederle N, Kloke O, Doberauer C, Becher R, Beelen DW, Schmidt CG (1986) Alphas- Interferon — erste Behandlungsergebnisse bei der chronischen myeloischen Leukämie. Dtsch Med Wochenschr 111: 765–7676

    Article  Google Scholar 

  44. Pedersen-Bjergaard J, Worm AM, Hainau B (1977) Blastic transformation of chronic myelocytic leukaemia: clinical manifestations, prognostic factors and results of therapy. Scand J Haematol 18: 292–300

    Article  PubMed  CAS  Google Scholar 

  45. Reinhard EH, Neely CL, Samples DM (1959) Radioactive phosporus in the treatment of chronic myelocytic leukemias: longterm results over a period of 15 years. Ann Intern Med 50: 942–958

    PubMed  CAS  Google Scholar 

  46. Rosenthal S, Canellos GP, Whang-Peng, Gralnick HR (1977) Blast crisis of chronic granulocytic leukemia: morphologic variants and therapeutic implications. Am J Med 63: 542–547

    Article  PubMed  CAS  Google Scholar 

  47. Rundles RW, Grizzle J, Bell WN, Corley CG, Frommeyer WB, Greenberg BG, Huguley CM, James GW, Jones R, Larsen WE, Loeb V, Leone LA, Palmer JG, Riser WH, Wilson SJ (1959) Comparison of chlorambucil and myleran in chronic lymphocytic and granulocytic leukemia. Am J Med 27: 424–432

    Article  Google Scholar 

  48. Schwartz JH, Canellos GP (1975) Hydroxyurea in the management of the hematologic complica¬tions of chronic granulocytic leukemia. Blood 46: 11–16

    PubMed  CAS  Google Scholar 

  49. Schwarzenberg L, Mathe G, Pouillart P, Weiner R, Locour J, Genin J, Schneider M, de Vassal F, Hayat M, Amiel JL, Schlumberger JR, Jasmin C, Rosenfeld C (1973) Hydroxyurea, leukapheresis, and splenectomy in chronic myeloid leukemia at the problastic phase. Br Med J [Clin Res] 1: 700–703

    Article  CAS  Google Scholar 

  50. Sharp JC, Joyner MV, Wayne AW, Kemp J, Crofts M, Birch ADJ, McArthur G, Lai S, Sterndale H, Williams Y (1979) Karyotypic conversion in Ph-l-positive chronic myeloid leukemia with combination chemotherapy. Lancet 1: 1370–1372

    Article  PubMed  CAS  Google Scholar 

  51. Smalley RV, Vogel J, Huguley CM, JUR, Miller D (1977) Chronic granulocytic leukemia: cytogenetic conversion of the bone marrow with cyclespecific chemotherapy. Blood 50: 107–113

    PubMed  CAS  Google Scholar 

  52. Sokal JE (1976) Evaluation of survival data for chronic myelocytic leukemia. Am J Hematol 1: 493–500

    Article  PubMed  CAS  Google Scholar 

  53. Southeastern Cancer Chemotherapy Cooperative Study Group (1963) Comparison of 6-mercap- topurine and busulfan in chronic granulocytic leukemia. Blood 21: 89–100

    Google Scholar 

  54. Spiers ASD, Galton DAG, Kaur J, Goldman JM (1975) Thioguanine as primary treatment for chronic granulocytic leukaemia. Lancet 1: 829–832

    Article  PubMed  CAS  Google Scholar 

  55. Spiers ASD, Goldman JM, Catovsky D, Costello C, Buskard NA, Galton DAG (1977) Multiple-drug chemotherapy for acute leukemia: the TRAMPCOL regimen: results in 86 patients. Cancer 40: 20–9

    Article  PubMed  CAS  Google Scholar 

  56. Talpaz M, McCredie K, Mavligit GM, Gutterman JU (1983) Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia. Blood 62: 689 - 692

    PubMed  CAS  Google Scholar 

  57. Talpaz M, Kantarjian HM, McCredie K, Trujillo JM, Keating MJ, Gutterman JU (1986) Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. N Engl J Med 314: 1065–1069

    Article  PubMed  CAS  Google Scholar 

  58. Thomas ED, Clift RA, Fefer A et al. (1986) Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med 104: 155–163

    PubMed  CAS  Google Scholar 

  59. Tura S, Zaccaria A, Corbelli G et al. (1984) Results of a prospective randomized trial of early splenectomy in chronic myeloid leukemia. Cancer 54: 333–338

    Article  Google Scholar 

  60. Vallejos CS, McCredie KB, Brittin GM, Freireich EJ (1973) Biological effects of repeated leukapheresis of patients with chronic myelogenous leukemia. Blood 42: 925–933

    PubMed  CAS  Google Scholar 

  61. Vallejos CS, Trujillo JM, Cork A, Bodey GP, McCredie KP, Freireich EJ (1974) Blastic crisis in chronic granulocytic leukemia: experience in 39 patients. Cancer 34: 1806–1812

    Article  PubMed  CAS  Google Scholar 

  62. Wolf DJ, Silver RT, Coleman M (1978) Splenectomy in chronic myeloid leukemia. Ann Intern Med 89: 684–689

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. Hehlmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Innere Medizin und Poliklinik, Universitätsklinikum Rudolf Virchow, Spandauer Damm 130, 1000, Standort Charlottenburg, Berlin 19, Germany

    Dieter Huhn

  2. II. Innere Abteilung, Krankenhaus Moabit, Turmstraße 21, 1000, Berlin 21, Germany

    Klaus Peter Hellriegel

  3. Innere Klinik und Poliklinik(Tumorforschung), Universitätsklinikum Essen, Hufelandstraße 55, 4300, Essen 1, Germany

    Norbert Niederle

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hehlmann, R. (1988). Cytostatic Therapy of Chronic Myelogenous Leukemia: Review and Perspectives. In: Huhn, D., Hellriegel, K.P., Niederle, N. (eds) Chronic Myelocytic Leukemia and Interferon. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73526-4_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73526-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19067-7

  • Online ISBN: 978-3-642-73526-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation