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Carcinoma of the Testis: Pathology

  • Chapter
Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The basis of the current classification of testicular germ cell tumors was established by the work of Friedman and Moore, who reviewed almost 1000 cases of testicular cancer and published their findings in 1946 (Friedman and Moore 1946). Refinements to their classification were based on observations of many but by Teilum in particular. Mostofi and Sobin, with the assistance of a distinguished group of pathologists, created the World Health Organization classification in the 1970s, the preferred classification in the United States. PUGH and his colleagues established a somewhat comparable classification, the British Testicular Tumor Panel classification. Skakkebaek and colleagues, through numerous publications, have demonstrated the importance of carcinoma in situ, or intratubular germ cell neoplasia, defining the pathogenesis of germ cell tumors. The classification of germ cell tumors created a framework to evaluate therapeutic strategies, leading to a dramatic decrease in the mortality among patients with a highly lethal tumor. Additionally, the work has led to a histogenetic scheme that has provided the framework to formulate hypotheses that can answer the many remaining questions concerning testicular cancer (Leahy 1992; Ginsburg 1997).

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  1. Kenneth Norris Jr Cancer Hospital and Research Institute, USC School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA

    P. W. Nichols MD (Professor of Pathology, Director of Laboratories)

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  1. Department of Radiation Oncology Kenneth Norris Jr. Cancer Hospital and Research Institute, University of Southern California School of Medicine, 1441 Eastlake Avenue, 90033-004, Los Angeles, CA, USA

    Zbigniew Petrovich MD, FACR (Professor of Radiation Oncology and Urology Chairman) (Professor of Radiation Oncology and Urology Chairman)

  2. Department of Urology, Catholic University of Leuven, University Hospitals Gasthuisberg, 49, Herestraat, B-3000, Leuven, Belgium

    Luc Baert MD, PhD (Professor and Chairman) (Professor and Chairman)

  3. Hylda Cohn/American Cancer Society, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

  4. Department of Radiation Oncology, Allegheny University of the Health Sciences Allegheny University Hospitals, Hahnemann Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

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Nichols, P.W. (1999). Carcinoma of the Testis: Pathology. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59839-5_16

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