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Yeast as a Window into Changes in Genome Complexity Due to Polyploidization

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Polyploidy and Genome Evolution

Abstract

Due to the long history of genetic analyses in yeasts and their experimental tractability, the yeast genome duplication provides important perspectives on the genome and population-level processes that follow whole-genome duplication (WGD). We discuss the history of the discovery of the Saccharomyces cerevisiae WGD, with special emphasis on the role of comparative genomics in its analysis. We then explore models of the WGD shaped population and species divergence, both at a gene level (e.g., Dobzhansky-Muller incompatibility) and from the perspective of recent work on secondary allopolyploidy in Saccharomyces pastorianus. Finally, we explore the selective forces that act on the WGD-produced paralogs and shape their patterns of loss and retention. In addition to discussing the dosage balance hypothesis as it applies to the yeast WGD, we explore the role of the WGD in shaping several complex metabolic and regulatory phenotypes.

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Acknowledgments

We would like to thank Michaël Bekaert, Patrick Edger, and Chris Pires for helpful discussions. This work was supported by the National Library of Medicine Biomedical and Health Informatics Training Fellowship [LM007089-19] (CMH) and the Reproductive Biology Group of the Food for the twenty-first century program at the University of Missouri (GCC).

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Authors and Affiliations

  1. MU Informatics Institute, University of Missouri, Columbia, MO, 65211, USA

    Corey M. Hudson & Gavin C. Conant

  2. Division of Animal Sciences, University of Missouri, Columbia, MO, USA

    Gavin C. Conant

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  1. Corey M. Hudson
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  2. Gavin C. Conant
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Correspondence to Gavin C. Conant .

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  1. , Florida Museum of Natural History, University of Florida, Museum Road, Gainesville, 32611, Florida, USA

    Pamela S. Soltis

  2. , Florida Museum of Natural History, University of Florida, Museum Road, Gainesville, 32611, Florida, USA

    Douglas E. Soltis

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Hudson, C.M., Conant, G.C. (2012). Yeast as a Window into Changes in Genome Complexity Due to Polyploidization. In: Soltis, P., Soltis, D. (eds) Polyploidy and Genome Evolution. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31442-1_15

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