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Sleeping sickness: a disease of the clock with nitric oxide involvement

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Progress in Human African Trypanosomiasis, Sleeping Sickness

Abstract

Although it was practically eradicated by the 1960s, sleeping sickness or human African trypanosomiasis (HAT) is now spreading rapidly and affecting more than 10% of the population in certain endemic areas [1]. This disease, described more than a century ago, was thought to be specific of Melanoids [2]. It is anchored by the geographical distribution of the tse-tse fly, which infects humans with a protozoa, Trypanosoma brucei gambiense (Western and Central Africa) or T. b. rhodesiense (Eastern Africa). The hemolymphatic phase (stage I) represents the invasion of the blood and lymphatic tissues and is followed by a meningoencephalitis (stage II), with the presence of trypanosomes in the cerebrospinal fluid (CSF) and perivascular infiltrates of lymphoplasmocytic cells [3].

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Authors
  1. A. Buguet
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  2. R. Cespuglio
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Editors and Affiliations

  1. Faculté de Médecine Institut d’Épidemiologie Neurologique et de Neurologie Tropicale, Université de Limoges, 2, rue du Dr. Marcland, 87025, Limoges, France

    Michel Dumas  & Bernard Bouteille  & 

  2. Unité de Physiologie de la Vigilance, Centre de Recherches du Service de Santé des Armées Émile Pardé, 38702, La Tronche Cedex, France

    Alain Buguet

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Buguet, A., Cespuglio, R. (1999). Sleeping sickness: a disease of the clock with nitric oxide involvement. In: Dumas, M., Bouteille, B., Buguet, A. (eds) Progress in Human African Trypanosomiasis, Sleeping Sickness. Springer, Paris. https://doi.org/10.1007/978-2-8178-0857-4_11

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  • DOI: https://doi.org/10.1007/978-2-8178-0857-4_11

  • Publisher Name: Springer, Paris

  • Print ISBN: 978-2-287-59655-1

  • Online ISBN: 978-2-8178-0857-4

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