Skip to main content
SpringerLink
Log in

Are Tissue Non-Esterified Fatty Acids (NEFA) Involved in the Impairment of Biochemical and Mechanical Processes during Acute Regional Ischemia in the Heart

  • Chapter
Myocardial Ischemia and Lipid Metabolism

Abstract

After extraction from capillary blood by myocardial tissue, non-esterified fatty acids (NEFA) can either be oxidized to deliver energy for electromechanical processes, taken up in fatty acid stores as triacylglycerides, or incorporated in membrane structures as glycerophospholipids. Beside these useful roles of NEFA for myocardial function, detrimental effects of these fatty acids have been described. Raised plasma levels of NEFA have been suggested to induce or facilitate arrhythmias in patients with myocardial infarction (1) or to extend the infarcted area (2). In vitro experiments with isolated enzymes and subcellular fractions have shown that NEFA can inhibit enzyme activities and mitochondrial energy production (for reviews see 3, 4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Oliver, M.F., Kurien, V.A., & Greenwood, T.W. (1968): Lancet 1: 710.

    Article  PubMed  CAS  Google Scholar 

  2. Opie, L.H., Tansey, M., & Kennelly, B.M. (1977): Lancet 2: 890.

    Article  PubMed  CAS  Google Scholar 

  3. Katz, A.M., & Messineo, F.C. (1981): Circ. Res. 48: 1.

    PubMed  CAS  Google Scholar 

  4. Van der Vusse, G.J. (1983): J. Drug Res. 8: 1579.

    Google Scholar 

  5. Hunneman, D.H., & Schweickhardt, C. (1982): J. Mol. Cell. Cardiol. 14: 339.

    Article  PubMed  CAS  Google Scholar 

  6. Van der Vusse, G.J., Roemen, T.H.M., & Reneiaan, R.S. (1980): Biochim. Biophys. Acta 617: 347.

    Google Scholar 

  7. Masters, T.N., & Glaviano, V.V. (1972): J. Pharmacol. Exp. Ther. 182: 246.

    PubMed  CAS  Google Scholar 

  8. Weishaar, R., Ashikawa, K., & Bing, B.J. (1979): Am. J. Cardiol. 43: 1137.

    Article  PubMed  CAS  Google Scholar 

  9. Weishaar, R., Sarma, J.S.M., Maruyama, Y., Fisher, R., & Bing, R.J. (1977): Cardiology 62: 2.

    Article  PubMed  CAS  Google Scholar 

  10. Suzuki, Y., Kamikawa, T., & Yamazaki, N. (1981): Jap. Heart J. 22: 377.

    Article  PubMed  CAS  Google Scholar 

  11. Suzuki, Y., Kamikawa, T., Kobayashi, A., Masumura, Y., & Yamazaki, N. (1981): Jap. Circ. J. 45: 687.

    Article  PubMed  CAS  Google Scholar 

  12. Oscai, L.B. (1979): Can. J. Physiol. Pharmacol. 57: 485.

    Article  PubMed  CAS  Google Scholar 

  13. Ahmed, S.S., Lee, C.H., Oldewurtel, H.A., & Regan, T.J. (1978): J. Clin. Invest. 61: 1123.

    Article  PubMed  CAS  Google Scholar 

  14. Regan, T.J., Passannante, A.J., Oldewurtel, H.A., Burke, W.M., & Ettinger, P.O. (1972): J. Appl. Physiol. 33: 325.

    PubMed  CAS  Google Scholar 

  15. Regan, T.J., Khan, M.I., Ettinger, P.O., Haider, B., Lyons, M.M., & Oldewurtel, H.A. (1974): J. Clin. Invest. 54: 740.

    Article  PubMed  CAS  Google Scholar 

  16. Regan, T.J., Wu, C.F., Yeh, C.K., Oldewurtel, H.A., & Haider, B. (1981): Circ. Res. 49: 1268.

    PubMed  CAS  Google Scholar 

  17. Haider, B., Achmed, S.S., Moschos, C.B., Oldewurtel, H.A., & Regan, T.J. (1977): Circ. Res. 40: 577.

    PubMed  CAS  Google Scholar 

  18. Regan, T.J., Markov, A., Khan, M.I., Jesrani, M.U., Oldewurtel, H.A., & Ettinger, P.O. (1972): Rec. Adv. Stud. Cardiac Struct. Metab. 1: 656.

    CAS  Google Scholar 

  19. Andrieu, J.L., Vial, C, Font, B., Goldschmidt, D., Lièvre, M., & Faucon, G. (1979): Arch. Int. Pharmacodyn. Therap. 237: 330.

    Google Scholar 

  20. Sakurai, I. (1977): Acta Pathol. Japan 27: 587.

    CAS  Google Scholar 

  21. Liu, M.-S., & Spitzer, J.J. (1977): Circ. Shock 4: 191.

    PubMed  CAS  Google Scholar 

  22. Messineo, F.C., Pinto, P.B., & Katz, A.M. (1980): J. Mol. Cell. Cardiol. 12: 725.

    Article  PubMed  CAS  Google Scholar 

  23. Feuvray, D., & Plouet, J. (1981): Circ. Res. 48: 740.

    PubMed  CAS  Google Scholar 

  24. Cowan, J.C., & Vaughan Williams, E.M. (1980): J. Mol. Cell. Cardiol. 12: 347.

    Article  PubMed  CAS  Google Scholar 

  25. Pressman, B.C., & Lardy, H.A. (1956): Biochim. Biophys. Acta 21: 458.

    Article  PubMed  CAS  Google Scholar 

  26. Borst, P., Loos, J.A., Christ, E.J., & Slater, E.C. (1962): Biochim. Biophys. Acta 62: 509.

    Article  PubMed  CAS  Google Scholar 

  27. Van der Vusse, G.J., Roemen, T.H.M., Prinzen, F.W., Coumans, W.A., & Reneman, R.S. (1982): Circ. Res. 50: 538.

    PubMed  Google Scholar 

  28. Prinzen, F.W., Van der Vusse, G.J., & Reneman, R.S. (1981): Basic Res. Cardiol. 76: 431.

    Article  PubMed  CAS  Google Scholar 

  29. Arts, T., & Reneman, R.S. (1980): Am. J. Physiol. 239: H432.

    PubMed  CAS  Google Scholar 

  30. Van der Vusse, G.J., Coumans, W.A., Van der Veen, F.H., Drake, A.J., Flameng, W., & Suy, R. (1983): Vase. Surg. In press.

    Google Scholar 

  31. Christie, W.W. (1973): IN Lipid Analysis, Pergamon Press, Oxford, p. 30.

    Google Scholar 

  32. Van der Vusse, G.J., Roemen, T.H.M., Prinzen, F.W., & Reneman, R.S. (1981): Basic Res. Cardiol. 76: 389.

    Article  PubMed  Google Scholar 

  33. Laurell, S., & Tibbling, G. (1966): Clin. Chim. Acta 16: 57.

    Article  Google Scholar 

  34. Rose, C.P., & Goresky, C.A. (1977): Circ. Res. 41: 534.

    PubMed  CAS  Google Scholar 

  35. Mishkin, S., Stein, L., Gatmaitan, Z., & Arias, I.M. (1972): Biochem. Biophys. Res. Commun. 47: 997.

    Article  PubMed  CAS  Google Scholar 

  36. Ockner, R.K., Manning, J.A., Poppenhausen, R.B., & Ho, W.K.L. (1972): Science 171: 56.

    Article  Google Scholar 

  37. Gloster, J., & Harris, P. (1977): Biochem. Biophys. Res. Commun. 74: 506.

    Article  PubMed  CAS  Google Scholar 

  38. Ramadoss, CS., Uyeda, K., & Johnston, J.M. (1976): J. Biol. Chem. 251: 98.

    PubMed  CAS  Google Scholar 

  39. Lea, M.A., & Weber, G. (1968): J. Biol. Chem. 243: 1096.

    PubMed  CAS  Google Scholar 

  40. Owen, P., Thomas, M., Young, V., & Opie, L.H. (1970): Am. J. Cardiol. 25: 562.

    Article  PubMed  CAS  Google Scholar 

  41. Rau, E.E., & Langer, G.A. (1978): Am. J. Physiol. 235: H537.

    PubMed  CAS  Google Scholar 

  42. Lamers, J.M.J., & Hulsmann, W.C. (1977): J. Mol. Cell. Cardiol. 9: 343.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Limburg, P. O. Box 616, 6200 MD, Maastricht, The Netherlands

    G. J. van der Vusse, F. W. Prinzen & R. S. Reneman

Authors
  1. G. J. van der Vusse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. W. Prinzen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. S. Reneman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Brescia, Brescia, Italy

    R. Ferrari  & O. Visioli  & 

  2. School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA

    A. M. Katz

  3. William S. Middleton Memorial Veteran Hospital, Madison, Wisconsin, USA

    A. Shug

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

van der Vusse, G.J., Prinzen, F.W., Reneman, R.S. (1984). Are Tissue Non-Esterified Fatty Acids (NEFA) Involved in the Impairment of Biochemical and Mechanical Processes during Acute Regional Ischemia in the Heart. In: Ferrari, R., Katz, A.M., Shug, A., Visioli, O. (eds) Myocardial Ischemia and Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4865-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4865-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4867-2

  • Online ISBN: 978-1-4684-4865-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation