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Pathophysiology of Menopausal Hot Flushes

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Neuroendocrinology of Aging

Abstract

In women, the most common and characteristic symptom of the climacteric is an episodic disturbance consisting of sudden flushing and perspiration, referred to as a “hot flush or flash.” It has been observed in 65–76% of women who go through the physiological menopause or have a bilateral ovariectomy (Hannan, 1927; Neugarten and Kraines, 1965; Jaszmann et al., 1969; Thompson et al.,1973; McKinlay and Jeffreys, 1974). Of those having flushes, 82% will experience the disturbance for more than 1 year (Jaszmann et al.,1969) and 25–50% will complain of the symptom for more than 5 years (Neugarten and Kraines, 1965; Thompson et al., 1973). Although hot flushes occur in millions of women, there have been few attempts to understand the pathophysiology of this symptom until recently.

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  1. Department of Obstetrics and Gynecology, University of California at Los Angeles School of Medicine, Los Angeles, California, 90024, USA

    Howard L. Judd

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  1. Department of Physiology, Neuroendocrine Research Laboratory, Michigan State University, 48824, East Lansing, Michigan, USA

    Joseph Meites

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© 1983 Plenum Press, New York

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Judd, H.L. (1983). Pathophysiology of Menopausal Hot Flushes. In: Meites, J. (eds) Neuroendocrinology of Aging. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4523-7_10

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