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Vasomotor Symptoms

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Skin, Mucosa and Menopause

Abstract

The menopausal transition can be categorized into several stages, which are accompanied by various changes that may have a significant impact on quality of life. Vasomotor symptoms (VMS) usually appear in the beginning of the menopausal transition and may persist until the end of life. These symptoms are common reasons for seeking medical care and include hot flashes or night sweats which last from 1 to 15 min and may involve sweating, palpitations, nausea, dizziness, chills, pain, or pressure in the head or chest; changes in breathing patterns and heart rate; and sleep disturbances. Although their physiopathology is not well known, it is thought that hot flashes may be caused by increased thermoregulatory responses, which lead to intense sensations of heat and flushing, accompanied by an increase in blood flow. The incidence and intensity of VMS may vary according to clinical factors such as ethnicity, obesity, and mood. Although several hormonal and nonhormonal treatments may be used to treat VMS, their risks and benefits should always be weighed on a case-by-case basis. To further explore this issue, this chapter will review the physiopathology, epidemiology, and treatment of VMS.

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References

  1. Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, et al. Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertil Steril. 2001;76(5):874–8.

    Article  CAS  PubMed  Google Scholar 

  2. Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, et al. Executive summary: Stages of Reproductive Aging Workshop (STRAW). Climacteric. 2001;4(4):267–72.

    Article  CAS  PubMed  Google Scholar 

  3. Joffe H, Groninger H, Soares CN, Nonacs R, Cohen LS. An open trial of mirtazapine in menopausal women with depression unresponsive to estrogen replacement therapy. J Womens Health Gend Based Med. 2001;10(10):999–1004.

    Article  CAS  PubMed  Google Scholar 

  4. Thurston RC, Joffe H. Vasomotor symptoms and menopause: findings from the Study of Women’s Health across the Nation. Gynecol Clin North Am. 2011;38(3):489–501.

    Article  Google Scholar 

  5. Deecher DC, Dorries K. Understanding the pathophysiology of vasomotor symptoms (hot flushes and night sweats) that occur in perimenopause, menopause, and postmenopause life stages. Arch Womens Ment Health. 2007;10(6):247–57.

    Article  CAS  PubMed  Google Scholar 

  6. Santoro N. Symptoms of menopause: hot flushes. Clin Obstet Gynecol. 2008;51(3):539–48.

    Article  PubMed  Google Scholar 

  7. Freedman RR. Hot flashes revisited. Menopause. 2000;7(1):3–4.

    Article  CAS  PubMed  Google Scholar 

  8. Miller EH. Women and insomnia. Clin Cornerstone. 2004;6(Suppl 1B):S8–18.

    PubMed  Google Scholar 

  9. Voda AM. Climacteric hot flash. Maturitas. 1981;3(1):73–90.

    Article  CAS  PubMed  Google Scholar 

  10. Soares CN. Insomnia in women: an overlooked epidemic? Arch Womens Ment Health. 2005;8(4):205–13.

    Article  CAS  PubMed  Google Scholar 

  11. Freeman EW, Sammel MD, Sanders RJ. Risk of long-term hot flashes after natural menopause: evidence from the Penn Ovarian Aging Study cohort. Menopause. 2014 [Epub ahead of print]

    Google Scholar 

  12. Freedman RR. Hot flashes: behavioral treatments, mechanisms, and relation to sleep. Am J Med. 2005;118(Suppl 12B):124–30.

    Article  PubMed  Google Scholar 

  13. Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women with hot flashes. Am J Obstet Gynecol. 1999;181(1):66–70.

    Article  CAS  PubMed  Google Scholar 

  14. Freedman RR, Norton D, Woodward S, Cornelissen G. Core body temperature and circadian rhythm of hot flashes in menopausal women. J Clin Endocrinol Metab. 1995;80(8):2354–8.

    CAS  PubMed  Google Scholar 

  15. Rebar RW, Spitzer IB. The physiology and measurement of hot flushes. Am J Obstet Gynecol. 1987;156(5):1284–8.

    Article  CAS  PubMed  Google Scholar 

  16. Berendsen HH. The role of serotonin in hot flushes. Maturitas. 2000;36(3):155–64.

    Article  CAS  PubMed  Google Scholar 

  17. Meldrum DR, Erlik Y, Lu JK, Judd HL. Objectively recorded hot flushes in patients with pituitary insufficiency. J Clin Endocrinol Metab. 1981;52(4):684–8.

    Article  CAS  PubMed  Google Scholar 

  18. Tataryn IV, Lomax P, Bajorek JG, Chesarek W, Meldrum DR, Judd HL. Postmenopausal hot flushes: a disorder of thermoregulation. Maturitas. 1980;2(2):101–7.

    Article  CAS  PubMed  Google Scholar 

  19. Thurston RC, Christie IC, Matthews KA. Hot flashes and cardiac vagal control: a link to cardiovascular risk? Menopause. 2010;17(3):456–61.

    PubMed Central  PubMed  Google Scholar 

  20. Sowers MR, Wilson AL, Karvonen-Gutierrez CA, Kardia SR. Sex steroid hormone pathway genes and health-related measures in women of 4 races/ethnicities: the Study of Women’s Health Across the Nation (SWAN). Am J Med. 2006;119(9 Suppl 1):S103–10.

    Article  CAS  PubMed  Google Scholar 

  21. Thurston RC, Sowers MR, Sutton-Tyrrell K, Everson-Rose SA, Lewis TT, Edmundowicz D, et al. Abdominal adiposity and hot flashes among midlife women. Menopause. 2008;15(3):429–34.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Thurston RC, Sowers MR, Sternfeld B, Gold EB, Bromberger J, Chang Y, et al. Gains in body fat and vasomotor symptom reporting over the menopausal transition: the study of women’s health across the nation. Am J Epidemiol. 2009;170(6):766–74.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Gold EB, Block G, Crawford S, Lachance L, FitzGerald G, Miracle H, et al. Lifestyle and demographic factors in relation to vasomotor symptoms: baseline results from the Study of Women’s Health Across the Nation. Am J Epidemiol. 2004;159(12):1189–99.

    Article  PubMed  Google Scholar 

  24. Gold EB, Leung K, Crawford SL, Huang MH, Waetjen LE, Greendale GA. Phytoestrogen and fiber intakes in relation to incident vasomotor symptoms: results from the Study of Women’s Health Across the Nation. Menopause. 2013;20(3):305–14.

    PubMed Central  PubMed  Google Scholar 

  25. Gold EB, Colvin A, Avis N, Bromberger J, Greendale GA, Powell L, et al. Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women’s health across the nation. Am J Public Health. 2006;96(7):1226–35.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Gibson C, Matthews K, Thurston R. Daily physical activity and hot flashes in the Study of Women’s Health Across the Nation (SWAN) Flashes Study. Fertil Steril. 2014;101(4):1110–6.

    Article  PubMed  Google Scholar 

  27. Bromberger JT, Meyer PM, Kravitz HM, Sommer B, Cordal A, Powell L, et al. Psychologic distress and natural menopause: a multiethnic community study. Am J Public Health. 2001;91(9):1435–42.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Freeman EW, Sammel MD, Lin H, Gracia CR, Kapoor S, Ferdousi T. The role of anxiety and hormonal changes in menopausal hot flashes. Menopause. 2005;12(3):258–66.

    Article  PubMed  Google Scholar 

  29. Hunter MS, Gupta P, Chedraui P, Blumel JE, Tserotas K, Aguirre W, et al. The International Menopause Study of Climate, Altitude, Temperature (IMS-CAT) and vasomotor symptoms. Climacteric. 2013;16(1):8–16.

    Article  CAS  PubMed  Google Scholar 

  30. Kravitz HM, Ganz PA, Bromberger J, Powell LH, Sutton-Tyrrell K, Meyer PM. Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition. Menopause. 2003;10(1):19–28.

    PubMed  Google Scholar 

  31. Joffe H, White DP, Crawford SL, McCurnin KE, Economou N, Connors S, et al. Adverse effects of induced hot flashes on objectively recorded and subjectively reported sleep: results of a gonadotropin-releasing hormone agonist experimental protocol. Menopause. 2013;20(9):905–14.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Greendale GA, Wight RG, Huang MH, Avis N, Gold EB, Joffe H, et al. Menopause-associated symptoms and cognitive performance: results from the study of women’s health across the nation. Am J Epidemiol. 2010;171(11):1214–24.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Weber MT, Rubin LH, Maki PM. Cognition in perimenopause: the effect of transition stage. Menopause. 2013;20(5):511–7.

    PubMed  Google Scholar 

  34. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.

    Article  CAS  PubMed  Google Scholar 

  35. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) research group. JAMA. 1998;280(7):605–13.

    Article  CAS  PubMed  Google Scholar 

  36. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA. 2002;288(1):49–57.

    Article  PubMed  Google Scholar 

  37. Thurston RC, Sutton-Tyrrell K, Everson-Rose SA, Hess R, Powell LH, Matthews KA. Hot flashes and carotid intima media thickness among midlife women. Menopause. 2011;18(4):352–8.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Thurston RC, Sutton-Tyrrell K, Everson-Rose SA, Hess R, Matthews KA. Hot flashes and subclinical cardiovascular disease: findings from the Study of Women’s Health Across the Nation Heart Study. Circulation. 2008;118(12):1234–40.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Maclennan AH, Broadbent JL, Lester S, Moore V. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004; (4):CD002978.

    Google Scholar 

  40. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric. 2012;15(2):115–24.

    Article  CAS  PubMed  Google Scholar 

  41. Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med. 2006;145(12):869–79.

    Article  PubMed  Google Scholar 

  42. de Villiers TJ, Gass ML, Haines CJ, Hall JE, Lobo RA, Pierroz DD, et al. Global consensus statement on menopausal hormone therapy. Climacteric. 2013;16(2):203–4.

    Article  PubMed  Google Scholar 

  43. North American Menopause Society. The 2012 hormone therapy position statement of: The North American Menopause Society. Menopause. 2012;19(3):257–71.

    Google Scholar 

  44. Schierbeck LL, Rejnmark L, Tofteng CL, Stilgren L, Eiken P, Mosekilde L, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012;345:e6409.

    Article  PubMed  Google Scholar 

  45. Sturdee DW, Pines A, International Menopause Society Writing G, Archer DF, Baber RJ, Barlow D, et al. Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health. Climacteric. 2011;14(3):302–20.

    Article  CAS  PubMed  Google Scholar 

  46. Fichera M, Rinaldi N, Tarascio M, Taschetta S, Caldaci LM, Catavorello A, et al. Indications and contraindications of hormone replacement therapy in menopause. Minerva Ginecol. 2013;65(3):331–44.

    CAS  PubMed  Google Scholar 

  47. Wender MCO, Freitas F, De Castro JAS, Caran JZ, De Oliveira PP. Climatério. In: Freitas FM CH, Rivoire WA, Passos EP, editors. Rotinas em ginecologia. 6th ed. Porto Alegre: Artmed; 2011. p. 700–22.

    Google Scholar 

  48. Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA. 2006;295(17):2057–71.

    Article  CAS  PubMed  Google Scholar 

  49. Nelken RS, Ozel BZ, Leegant AR, Felix JC, Mishell Jr DR. Randomized trial of estradiol vaginal ring versus oral oxybutynin for the treatment of overactive bladder. Menopause. 2011;18(9):962–6.

    Article  PubMed  Google Scholar 

  50. Anderson GL, Judd HL, Kaunitz AM, Barad DH, Beresford SA, Pettinger M, et al. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women’s Health Initiative randomized trial. JAMA. 2003;290(13):1739–48.

    Article  CAS  PubMed  Google Scholar 

  51. Greiser CM, Greiser EM, Doren M. Menopausal hormone therapy and risk of lung cancer-systematic review and meta-analysis. Maturitas. 2010;65(3):198–204.

    Article  CAS  PubMed  Google Scholar 

  52. Oh SW, Myung SK, Park JY, Lym YL, Ju W. Hormone therapy and risk of lung cancer: a meta-analysis. J Womens Health (Larchmt). 2010;19(2):279–88.

    Article  Google Scholar 

  53. Umland EM. Treatment strategies for reducing the burden of menopause-associated vasomotor symptoms. J Manag Care Pharm. 2008;14(3 Suppl):14–9.

    PubMed  Google Scholar 

  54. Kenemans P, Bundred NJ, Foidart JM, Kubista E, von Schoultz B, Sismondi P, et al. Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial. Lancet Oncol. 2009;10(2):135–46.

    Article  CAS  PubMed  Google Scholar 

  55. Wolff EF, He Y, Black DM, Brinton EA, Budoff MJ, Cedars MI, et al. Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS). Fertil Steril. 2013;99(5):1385–91.

    Article  PubMed Central  PubMed  Google Scholar 

  56. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. JAMA. 1995;273(3):199–208.

    Article  Google Scholar 

  57. Smith NL, Wiley JR, Legault C, Rice KM, Heckbert SR, Psaty BM, et al. Effect of progestogen and progestogen type on hemostasis measures in postmenopausal women: the Postmenopausal Estrogen/Progestin Intervention (PEPI) study. Menopause. 2008;15(6):1145–50.

    Article  PubMed  Google Scholar 

  58. Formoso G, Perrone E, Maltoni S, Balduzzi S, D’Amico R, Bassi C, et al. Short and long term effects of tibolone in postmenopausal women. Cochrane Database Syst Rev; 2012;(2):CD008536.

    Google Scholar 

  59. Cummings SR, Ettinger B, Delmas PD, Kenemans P, Stathopoulos V, Verweij P, et al. The effects of tibolone in older postmenopausal women. N Engl J Med. 2008;359(7):697–708.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  60. Palacios S. Advances in hormone replacement therapy: making the menopause manageable. BMC Womens Health. 2008;8:22.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Thacker HL. Assessing risks and benefits of nonhormonal treatments for vasomotor symptoms in perimenopausal and postmenopausal women. J Womens Health (Larchmt). 2011;20(7):1007–16.

    Article  Google Scholar 

  62. Stearns V. Clinical update: new treatments for hot flushes. Lancet. 2007;369(9579):2062–4.

    Article  PubMed  Google Scholar 

  63. Stearns V, Slack R, Greep N, Henry-Tilman R, Osborne M, Bunnell C, et al. Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial. J Clin Oncol. 2005;23(28):6919–30.

    Article  CAS  PubMed  Google Scholar 

  64. Kelly CM, Juurlink DN, Gomes T, Duong-Hua M, Pritchard KI, Austin PC, et al. Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ. 2010;340:c693.

    Article  PubMed Central  PubMed  Google Scholar 

  65. FDA. FDA approves the first non-hormonal treatment for hot flashes associated with menopause 2013 [Oct 7 2013]. Available from: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm359030.htm

  66. Archer DF, Seidman L, Constantine GD, Pickar JH, Olivier S. A double-blind, randomly assigned, placebo-controlled study of desvenlafaxine efficacy and safety for the treatment of vasomotor symptoms associated with menopause. Am J Obstet Gynecol. 2009;200(2):172.e1–10.

    Google Scholar 

  67. Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, LaVasseur BI, Barton DL, et al. Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet. 2000;356(9247):2059–63.

    Article  CAS  PubMed  Google Scholar 

  68. Speroff L, Gass M, Constantine G, Olivier S, Study I. Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: a randomized controlled trial. Obstet Gynecol. 2008;111(1):77–87.

    Article  CAS  PubMed  Google Scholar 

  69. Archer DF, Pinkerton JV, Guico-Pabia CJ, Hwang E, Cheng RF, Study I. Cardiovascular, cerebrovascular, and hepatic safety of desvenlafaxine for 1 year in women with vasomotor symptoms associated with menopause. Menopause. 2013;20(1):47–56.

    PubMed  Google Scholar 

  70. Kerwin JP, Gordon PR, Senf JH. The variable response of women with menopausal hot flashes when treated with sertraline. Menopause. 2007;14(5):841–5.

    Article  PubMed  Google Scholar 

  71. Gordon PR, Kerwin JP, Boesen KG, Senf J. Sertraline to treat hot flashes: a randomized controlled, double-blind, crossover trial in a general population. Menopause. 2006;13(4):568–75.

    Article  PubMed  Google Scholar 

  72. Kimmick GG, Lovato J, McQuellon R, Robinson E, Muss HB. Randomized, double-blind, placebo-controlled, crossover study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen. Breast J. 2006;12(2):114–22.

    Article  PubMed  Google Scholar 

  73. Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H, et al. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. JAMA. 2011;305(3):267–74.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  74. Pandya KJ, Morrow GR, Roscoe JA, Zhao H, Hickok JT, Pajon E, et al. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet. 2005;366(9488):818–24.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  75. Guttuso Jr T, Kurlan R, McDermott MP, Kieburtz K. Gabapentin’s effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol. 2003;101(2):337–45.

    Article  CAS  PubMed  Google Scholar 

  76. Yadav M, Volkar J. Potential role of gabapentin and extended-release gabapentin in the management of menopausal hot flashes. Int J Gen Med. 2013;6:657–64.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  77. Butt DA, Lock M, Lewis JE, Ross S, Moineddin R. Gabapentin for the treatment of menopausal hot flashes: a randomized controlled trial. Menopause. 2008;15(2):310–8.

    Article  PubMed  Google Scholar 

  78. Pandya KJ, Raubertas RF, Flynn PJ, Hynes HE, Rosenbluth RJ, Kirshner JJ, et al. Oral clonidine in postmenopausal patients with breast cancer experiencing tamoxifen-induced hot flashes: a University of Rochester Cancer Center Community Clinical Oncology Program study. Ann Intern Med. 2000;132(10):788–93.

    Article  CAS  PubMed  Google Scholar 

  79. L’Esperance S, Frenette S, Dionne A, Dionne JY. Comite de l’evolution des pratiques en o. Pharmacological and non-hormonal treatment of hot flashes in breast cancer survivors: CEPO review and recommendations. Support Care Cancer. 2013;21(5):1461–74.

    Article  PubMed  Google Scholar 

  80. Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause. 2009;16(6):1156–66.

    Article  PubMed Central  PubMed  Google Scholar 

  81. Cramer H, Lauche R, Langhorst J, Dobos G. Effectiveness of yoga for menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2012;2012:863905.

    Article  PubMed Central  PubMed  Google Scholar 

  82. Daley AJ, Stokes-Lampard HJ, Macarthur C. Exercise to reduce vasomotor and other menopausal symptoms: a review. Maturitas. 2009;63(3):176–80.

    Article  CAS  PubMed  Google Scholar 

  83. Lipov EG, Joshi JR, Xie H, Slavin KV. Updated findings on the effects of stellate-ganglion block on hot flushes and night awakenings. Lancet Oncol. 2008;9(9):819–20.

    Article  PubMed  Google Scholar 

  84. Haest K, Kumar A, Van Calster B, Leunen K, Smeets A, Amant F, et al. Stellate ganglion block for the management of hot flashes and sleep disturbances in breast cancer survivors: an uncontrolled experimental study with 24 weeks of follow-up. Ann Oncol. 2012;23(6):1449–54.

    Article  CAS  PubMed  Google Scholar 

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Wender, M.C.O., de Oliveira, P.P. (2015). Vasomotor Symptoms. In: Farage, M., Miller, K., Fugate Woods, N., Maibach, H. (eds) Skin, Mucosa and Menopause. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44080-3_30

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