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MSCs for the Treatment of Stroke, Spinal Cord Injury, and Traumatic Brain Injury: From Bench Work to Clinical Trials

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Mesenchymal Stromal Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Stroke, spinal cord injury, and traumatic brain injury are the major three causes of central nervous system injury. After the acute phase, most patients are left with significant motor, cognitive, and social impairments. Few treatments exist and there are no current therapeutic interventions altering their underlying pathological processes via tissue salvage, support, repair, or replacement at the cellular or subcellular level. Recent evidence suggests that the cell-based therapy exerts therapeutic benefits in relevant preclinical animal models. Furthermore, some cell types, like MSCs, have advanced into clinical trials. Here, we present the current status of MSCs in stroke, SCI, and TBI therapy from preclinical studies to clinical trials, with an emphasis on dosage, timing, and routes of delivery. We also discuss possible cellular and molecular mechanisms of action that mediate the effects of MSCs in these different disease models. Finally, we end with a discussion of important issues that require future study.

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Authors and Affiliations

  1. Department of Neurology, University of Texas Medical School at Houston, UT-Health, Houston, TX, 77030, USA

    Bing Yang M.D., Ramy El Khoury M.D. & Sean I. Savitz M.D.

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  1. Bing Yang M.D.
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  2. Ramy El Khoury M.D.
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  3. Sean I. Savitz M.D.
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Correspondence to Sean I. Savitz M.D. .

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  1. Madison School of Medicine and Public He, Department of Medicine, Hematology/Oncol, University of Wisconsin, 1111 Highland Avenue MC2275, Madison, 53705, USA

    Peiman Hematti

  2. Princess Margaret Hospital, Cell Therapy Program, University of Toronto, University Avenue 610, Toronto, M5G 2M9, Ontario, Canada

    Armand Keating

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Yang, B., El Khoury, R., Savitz, S.I. (2013). MSCs for the Treatment of Stroke, Spinal Cord Injury, and Traumatic Brain Injury: From Bench Work to Clinical Trials. In: Hematti, P., Keating, A. (eds) Mesenchymal Stromal Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5711-4_35

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