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Molecular Comparisons of the D-Type Retroviruses

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RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding

Part of the book series: Developments in Oncology ((DION,volume 28))

Abstract

The D-type retroviruses represent the most recently discovered genus within the sub-family oncovirinae of the family Retroviridae. The assignment of viruses into this group has been primarily on the basis of similarities in virus structure and morphogenesis. Mason-Pfizer monkey virus (M-PMV), the prototype D-type retrovirus, was isolated from a breast carcinoma of a female rhesus monkey by Jensen et al. (12) in 1970. The virus has properties in common with both the mammalian B-type viruses (e.g. mouse mammary tumor virus, MMTV) and C-type viruses (e.g. baboon endogenous virus, BaEV) but is distinct from both (2, 3). Like MMTV, M-PMV preassembles a virus core structure or A-type particle within the cell, and thus virus particles bud from the plasma membrane with a complete nucleoid (Fig 1, panels a and b). However, the morphology of the mature D-type virion more closely resembles that of C-type viruses, in that in general the condensed, cylindrical nucleoid is centrally located (Fig.l, panel c) in contrast to the eccentric location of the B-type nucleoid. Furthermore, the virion lacks the dense fringe of glycoprotein seen on MMTV, possessing instead a halo of knobs or knobbed spikes (Fig. 1, panels d,e and f). A second feature in common with MMTV is the presence of a reverse transcriptase with a preference for magnesium over manganese (4). The latter divalent cation is preferred by most mammalian C-type retrovirus enzymes (5).

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Authors and Affiliations

  1. Laboratory for Special Cancer Research, University of Alabama, Birmingham, Alabama, USA

    E. Hunter, C. S. Barker, J. Bradac, S. Chatterjee, R. Desrosiers & J. W. Wills

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  1. E. Hunter
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  2. C. S. Barker
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  3. J. Bradac
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  4. S. Chatterjee
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  5. R. Desrosiers
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  1. AMC Cancer Research Center, Denver, Colorado, USA

    Philip Furmanski , Jean Carol Hager  & Marvin A. Rich ,  & 

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© 1985 Martinus Nijhoff Publishing, Boston

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Hunter, E., Barker, C.S., Bradac, J., Chatterjee, S., Desrosiers, R., Wills, J.W. (1985). Molecular Comparisons of the D-Type Retroviruses. In: Furmanski, P., Hager, J.C., Rich, M.A. (eds) RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding. Developments in Oncology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2583-3_27

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  • DOI: https://doi.org/10.1007/978-1-4613-2583-3_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9620-1

  • Online ISBN: 978-1-4613-2583-3

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