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Pathogenesis and Treatment of Membranous Nephropathy

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Nephrology Forum

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Abstract

A 19-year-old woman was admitted to New England Medical Center Hospital (NEMCH) for evaluation of the nephrotic syndrome. The patient was in excellent health until proteinuria was first detected 10 months earlier during the third month of her first pregnancy. Twenty-four-hour urine protein excretion remained in the 5–10-g range, and progressive pedal, hand, and periorbital edema developed. During the final weeks of the pregnancy, hypertension was present (systolic blood pressure, 140–150 mmHg; diastolic blood pressure, 90–96 mmHg). A healthy infant girl was delivered approximately 3 months prior to admission. Following delivery, the edema persisted. The patient’s serum albumin concentration varied between 3.1 and 2.0 g/100 m1, serum creatinine concentration remained normal, and 24-h urine protein excretion varied between 4 and 15 g.

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Authors
  1. J. Stewart Cameron
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Editors and Affiliations

  1. Michael Reese Hospital and Medical Center, University of Chicago School of Medicine, Chicago, Illinois, USA

    Jordan J. Cohen

  2. New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

    John T. Harrington  & Jerome P. Kassirer  & 

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© 1983 International Society of Nephrology

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Cameron, J.S. (1983). Pathogenesis and Treatment of Membranous Nephropathy. In: Cohen, J.J., Harrington, J.T., Kassirer, J.P. (eds) Nephrology Forum. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5465-2_2

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  • DOI: https://doi.org/10.1007/978-1-4612-5465-2_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-90764-2

  • Online ISBN: 978-1-4612-5465-2

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