Skip to main content

Chronic Obstructive Pulmonary Disease

  • Chapter
Radiologic Diagnosis of Chest Disease

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow obstruction that does not markedly change over months of observation and is pathologically usually the result of chronic bronchitis or emphysema (1–3). It is estimated that 14–15 million people in the USA have COPD, with approximately 12.5 million having chronic bronchitis and 1.65–2 million emphysema (2). Asthma is highly prevalent, affecting an estimated 11 million people (4). There is evidence that the prevalence of asthma and COPD are increasing (5). Vollmer and colleagues noted an increased, prevalence of asthma and chronic airflow obstruction (CAO) over the period 1967–1987 in all age groups except males aged 65 and older who were enrolled in a large health maintenance organization (6). Every 5 years between 1950 and 1970 the death rate for obstructive respiratory disease doubled in the USA (7,8). COPD is the fourth leading cause of death in the USA, with 85 544 patients dying from COPD in 1991(2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Higgins M (1984) Epidemiology of COPD. State of the art. Chest 85:3S–8S.

    PubMed  CAS  Google Scholar 

  2. American Theracic Society (1995) Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease: Definitions, epidemiology, pathophysiology and staging. Am J Respir Crit Care Med 152:578–584.

    Google Scholar 

  3. Senior R, Anthonisen N (1998) Chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 157:S139–147.

    PubMed  CAS  Google Scholar 

  4. Dykewicz M, Ledford D (1998) Recent findings in asthma likely to impact patient care. Compr Ther 24:187–193.

    PubMed  CAS  Google Scholar 

  5. O’Byrne P, Postma D (1999) The many faces of airway inflammation. Asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159:S41-S66.

    PubMed  Google Scholar 

  6. Vollmer W, Osborne M, Buist A (1998) 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. Am J Respir Crit Care Med 157:1079–1084.

    PubMed  Google Scholar 

  7. Burrow B (1973) Foreward, symposium on chronic respiratory disease. Med Clin North Am 57:545.

    Google Scholar 

  8. Burrows B (1990) Airways obstructive diseases: Pathologenetic mechanisms and natural histories of the disorders. Med Clin North Am 74:547–559.

    PubMed  CAS  Google Scholar 

  9. Ferris B, Jr (1973) Chronic bronchitis and emphysema. Classification and epidemiology. Med Clin North Am 57:637–649.

    PubMed  Google Scholar 

  10. Murray CJ, L#aaopez AD (1997) Global mortality, disability, and the contribution of risk factors: Global burden of disease study [see comments]. Lancet 349:1436–1442.

    PubMed  CAS  Google Scholar 

  11. Fletcher CM, Pride NB (1984) Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium [editorial]. Thorax 39:81–85.

    PubMed  CAS  Google Scholar 

  12. Pride NB, Burrows B (1995) Development of impaired lung function: Natural history and risk factors. In Calverly P, Pride N (eds) Chronic obstructive pulmonary disease. Chapman & Hall, London, pp 69–91.

    Google Scholar 

  13. Petty TL, Weinmann GG (1997) Building a national strategy for the prevention and management of and research in chronic obstructive pulmonary disease. National Heart, Lung, and Blood Institute workshop summary, Bethesda, MD 29–31 August 1995 [see comments]. JAMMA 277:246–253.

    CAS  Google Scholar 

  14. Murray JF, Nadel JA (1994) Textbook of respiratory medicine, vol. 2,2nd edn. WB Saunders, Philadelphia, p. 2739.

    Google Scholar 

  15. Kips J, Pauwels R (1999) Airway wall remodelling: Does it occur and what does it mean? Clin Exp Allergy 29:1457–1466.

    PubMed  CAS  Google Scholar 

  16. Anthonisen N (1989) Prognosis in chronic obstructive pulmonary disease: Results from multicenter clinical trials. Am Rev Respir Dis 140:S95–S99.

    PubMed  CAS  Google Scholar 

  17. Nisar M, Earis J, Pearson M, et al. (1992) Acute bronchodilator trials in chronic obstructive pulmonary disease. Am Rev Respir Dis 146:555–559.

    PubMed  CAS  Google Scholar 

  18. Kesten S, Chapman K (1993) Physician perceptions and management of COPD. Chest 104:254–258.

    PubMed  CAS  Google Scholar 

  19. Kesten S, Rebuck A (1994) Is the short-term response to inhaled β-adrenergic agonist sensitive or specific for distinguishing between asthma and COPD? Chest 105:1042–1045.

    PubMed  CAS  Google Scholar 

  20. Beasley R, Roche W, Roberts J, (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139:806–817.

    PubMed  CAS  Google Scholar 

  21. Chetta A, Foresi A, Deldonno M, et al. (1996) Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. Am Rev Respir Crit Care Med 153:910–917.

    CAS  Google Scholar 

  22. Pratt P (1988) Emphysema and chronic airways disease. In, Dail D, Hammar S (eds) Pulmonary pathology. Springer-Verlag, New York, pp 654–659.

    Google Scholar 

  23. Kazerooni EA, Whyte RI, Flint A, et al. (1997) Imaging of emphysema and lung volume reduction surgery. Radiogrpahics 17:1023–1036.

    CAS  Google Scholar 

  24. Chanez P, Vignola A, O’Shaugnessy T, et al. (1997) Corticosteroid reversibility in COPD is related to features of asthma. Am Rev Respir Crit Care Med, 155:1529–1534.

    CAS  Google Scholar 

  25. Lacoste J, Bousquet J, Chanez P, et al. (1993) Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol 92:537–548.

    PubMed  CAS  Google Scholar 

  26. van Scayck C (1996) Diagnosis of asthma and chronic obstructive pulmonary disease in general practice. Br J Gen Pract 46:193–197.

    Google Scholar 

  27. Mclvor A, Chapman K (1996) Diagnosis of chronic obstructive pulmonary disease and differentiation from asthma. Curr Opin Pulm Med 2:148–154.

    Google Scholar 

  28. Burrows B, Bloom JW, Traver G A, et al. (1987) The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. N Engl J Med 317:1309–1314.

    PubMed  CAS  Google Scholar 

  29. Silverman E, Chapman H, Drazen J, et al. (1998) Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med 157:1770–1778.

    PubMed  CAS  Google Scholar 

  30. Holleman D, Simel D, Goldberg J (1993) Diagnosis of obstructive airways disease from the clinical examination. J Gen Intern Med 8:63–68.

    PubMed  Google Scholar 

  31. Badgett R, Tanaka D, Hunt D, et al. (1994) The clinical evaluation for diagnosing obstructive airways disease in high-risk patients. Chest 106:1427–1431.

    PubMed  CAS  Google Scholar 

  32. Holleman D, Jr, Simel D (1995) Does the clinical examination predict airflow limitation? JAMA 273:313–319.

    PubMed  Google Scholar 

  33. Emerman C, Lukens T, Effron D (1994) Physician estimation of FEV1 in acute exacerbation of COPD. Chest 105:1709–1712.

    PubMed  CAS  Google Scholar 

  34. Martin A, Landau L, Phelan P (1980) Lung function in young adults who had asthma in childhood. Am Rev Respir Dis 122:609–616.

    PubMed  CAS  Google Scholar 

  35. Gerritsen J, Koeter G, Postma D, et al. (1989) Prognosis of asthma from childhood to adulthood. Am Rev Respir Dis 140:1325–1330.

    PubMed  CAS  Google Scholar 

  36. Panhuysen C, Vonk J, Koeter G, et al. (1997) Adult patients may outgrow their asthma: A 25-year follow-up study. Am J Respir Crit Care Med 155:1267–1272.

    PubMed  CAS  Google Scholar 

  37. Ulrik C, Backer V (1999) Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J 14:892–896.

    PubMed  CAS  Google Scholar 

  38. Postma D, Lebowitz M (1995) Persistence and new onset of asthma and chronic bronchitis evaluated longitudinally in a community population sample of adults. Arch Intern Med 155:1393–1399.

    PubMed  CAS  Google Scholar 

  39. Anthonisen N, Connett J, Kiley J, et al. (1994) The effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline in FEV1 The lung health study. JAMA 272:1497–1505.

    PubMed  CAS  Google Scholar 

  40. National Asthma Education Program NH, Lung and Blood Institute, National Institutes of Health. (1997) Guidelines for the diagnosis and management of asthma. NIH Publications no. 97–4051.

    Google Scholar 

  41. Jain P, Kavuru M, Emerman C, et al. (1998) Utility of peak expiratory flow monitoring. Chest 114:861–876.

    PubMed  CAS  Google Scholar 

  42. Martinez F (1997) Pulmonary function testing. In Khan M, Lynch J III, (eds) Pulmonary disease. Diagnosis and therapy. A practical approach. Williams & Wilkins, Baltimore, MD, pp 107–141.

    Google Scholar 

  43. Badgett RG, Tanaka DJ, Hunt DK (1993) Can moderate chronic pulmonary disease be diagnosed by historical and physical findings alone? Am J Med 94:188–196.

    PubMed  CAS  Google Scholar 

  44. American Thoracic Society (1991) Lung function testing: Selection of reference values and interpretative strategies. Am Rev Respir Dis 144:1202–1218.

    Google Scholar 

  45. Linden-Smith J, Morrison D, Hernandez P, et al. (1999) Overdiagnosis of asthma? A community survey. Am J Respir Crit Care Med l59(Suppl3):A135.

    Google Scholar 

  46. Hudon C, Turcotte H, Laviolette M, et al. (1997) Characteristics of bronchial asthma with incomplete reversibility of airflow obstruction. Ann Allergy Asthma Immunol 78:195–202.

    PubMed  CAS  Google Scholar 

  47. Boulet L, Turcotte H, Hudon C et al. (1998) Clinical, physiological and radiological features of asthma with incomplete reversibility of airflow obstruction compared with those of COPD. Can Respir J 5:270–277.

    PubMed  CAS  Google Scholar 

  48. Brown P, Greville H, Finucane K (1984) Asthma and irreversible airflow obstruction. Thorax 39:131–136.

    PubMed  CAS  Google Scholar 

  49. Callahan CM, Dittus RS, Katz BP (1991) Oral corticosteroid therapy for patients with stable chronic obstructive pulmonary disease. A meta-analysis. Ann Intern Med 114:216–223.

    PubMed  CAS  Google Scholar 

  50. Callahan C, Dittus R, Katz B (1991) Oral corticosteroid therapy for patients with stable chronic obstructive pulmonary disease. A meta-analysis. Ann Intern Med 114:216–223.

    PubMed  CAS  Google Scholar 

  51. Fujimoto K, Kubo K, Yamamoto H, et al. (1999) Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. Chest 115:697–702.

    PubMed  CAS  Google Scholar 

  52. Cotton D, Soparkar G, Graham B (1996) Diffusing capacity in the clinical assessment of chronic airflow obstruction. Med Clin North Am 80:549–564.

    PubMed  CAS  Google Scholar 

  53. Collard P, Njinou B, Nejadnik B, et al. (1994) Single breath diffusing capacity for carbon monoxide in stable asthma. Chest 105:1426–1429.

    PubMed  CAS  Google Scholar 

  54. Stewart R (1988) Carbon monoxide diffusing capacity in asthmatic patients with mild airflow limitation. Chest 94:332–336.

    PubMed  CAS  Google Scholar 

  55. Morrison NJ, Abboud R, Ramadan F, et al. (1989) Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema. Am Rev Respir Dis 139:1179–1187.

    PubMed  CAS  Google Scholar 

  56. Knudson R, Kalternborn W, Burrows B (1990) Single breath carbon monoxide transfer factor in different forms of chronic airflow obstruction in a general population sample. Thorax 45:524–529.

    Google Scholar 

  57. Klein J, Gamsu G, Webb W, et al. (1992) High-resolution CT diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity. Radiology 182:817–821.

    PubMed  CAS  Google Scholar 

  58. Gelb A, Zamel N, Hogg J, et al. (1998) Pseudophysiologic emphysema resulting from severe small-airways disease. Am J Respir Crit Care Med 158:815–819.

    PubMed  CAS  Google Scholar 

  59. Chin NK, Lim TK (1998) A 39-year-old smoker with effort dyspnea, normal spirometry results, and low diffusing capacity. Chest 113:231–233.

    PubMed  CAS  Google Scholar 

  60. Arakawa H, Webb WR (1998) Air trapping on expiratory high-resolution CT scans in the absence of inspiratory scan abnormalities: Correlation with pulmonary function tests and differential diagnosis. AJR 170:1349–1353.

    PubMed  CAS  Google Scholar 

  61. Webb WR (1997) Radiology of obstructive pulmonary disease. AJR 169:637–647.

    PubMed  CAS  Google Scholar 

  62. Newell JD, Chan ED, Martin RJ (2000) Imaging of airway disease. In Lynch DA, Newell JD, Lee JS (eds) Imaging of diffuse lung disease. B.C. Decker, Hamilton Ontario, p 173.

    Google Scholar 

  63. Paganin F, Trussard V, Seneterre E, et al. (1992) Chest radiography and high resolution computed tomography of the lungs in asthma. Am Rev Respir Dis 146:1084–1087.

    PubMed  CAS  Google Scholar 

  64. Lynch DA, Newell JD, Tschomper BA, (1993) Uncomplicated asthma in adults: Comparison of CT appearance of the lungs in asthmatic and healthy subjects. Radiology 188:829–833.

    PubMed  CAS  Google Scholar 

  65. Boulet LP, Turcotte H, Hudon C, et al. (1998) Clinical, physiological and radiological features of asthma with incomplete reversibility of airflow obstruction compared with those of COPD. Can Respir J 5:270–277.

    PubMed  CAS  Google Scholar 

  66. Carr DH, Hibon S, Rubens M, et al. (1998) Peripheral airways obstruction on high-resolution computed tomography in chronic severe asthma. Respir Med 92:448–453.

    PubMed  CAS  Google Scholar 

  67. Grenier P, Mourey-Gerosa I, Benali K, et al. (1996) Abnormalities of the airways and lung parenchyma in asthmatics: CT observations in 50 patients and inter- and intraobserver variability. Eur Radiol 6:199–206.

    PubMed  CAS  Google Scholar 

  68. Park JW, Hong YK, Kim CW, et al. (1997) High-resolution computed tomography in patients with bronchial asthma: Correlation with clinical features, pulmonary functions and bronchial hyper-responsiveness. J Invest Allergol Clin Immunol 7:186–192.

    CAS  Google Scholar 

  69. Park CS, Müller NL, Worthy SA, et al. (1997) Airway obstruction in asthmatic and healthy individuals: Inspiratory and expiratory thin-section CT findings. Radiology 203:361–367.

    PubMed  CAS  Google Scholar 

  70. Awadh N, Müller NL, Park CS et al. (1998) Airway wall thickness in patients with near fatal asthma and control groups: Assessment with high resolution computed tomographic scanning. Thorax 53:248–253.

    PubMed  CAS  Google Scholar 

  71. Paganin F, Seneterre E, Chanez P, et al. (1996) Computed tomography of the lungs in asthma: Influence of disease severity and etiology. Am J Respir Crit Care Med 153:110–114.

    PubMed  CAS  Google Scholar 

  72. Biernacki W, Redpath AT, Best JJ, et al. (1997) Measurement of CT lung density in patients with chronic asthma [see comments]. Eur Respir J 10:2455–2459.

    PubMed  CAS  Google Scholar 

  73. Kinsella M, Müller NL, Staples C, et al. (1988) Hyperinflation in asthma and emphysema. Assessment by pulmonary function testing and computed tomography. Chest 94:286–289.

    PubMed  CAS  Google Scholar 

  74. Goldin JG, McNitt-Gray MF, Sorenson SM, et al. (1998) Airway hyperreactivity: Assessment with helical thin-section CT. Radiology 208:321–329.

    PubMed  CAS  Google Scholar 

  75. Kee ST, Fahy JV, Chen DR (1996) High-resolution computed tomography of airway changes after induced bronchoconstriction and bronchodilation in asthmatic volunteers. Acad Radiol 3:389–394.

    PubMed  CAS  Google Scholar 

  76. Okazawa M, Müller N, McNamara AE, et al. (1996) Human airway narrowing measured using high resolution computed tomography. Am J Respir Crit Care Med 154:1557–1562.

    PubMed  CAS  Google Scholar 

  77. Takasugi J, Godwin J (1998) Radiology of chronic obstructive pulmonary disease. Radiol Clin North Am 36:29–55.

    PubMed  CAS  Google Scholar 

  78. Hartman TE, Tazelaar HD, Swensen S J, et al. (1997) Cigarette smoking: CT and pathologic findings of associated pulmonary diseases. Radiographics 17:377–390.

    PubMed  CAS  Google Scholar 

  79. Remy-Jardin M, Remy J, Boulenguez C, et al. (1993) Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers: CT evaluation and correlation with pulmonary function tests. Radiology 186:107–115.

    PubMed  CAS  Google Scholar 

  80. Pratt PC (1987) Radiographic appearance of the chest in emphysema. Invest Radiol 22:927–929.

    PubMed  CAS  Google Scholar 

  81. Thurlbeck WM, Simon G (1978) Radiographic appearance of the chest in emphysema. AJR 130:429–440.

    PubMed  CAS  Google Scholar 

  82. Pratt PC (1987) Role of conventional chest radiography in diagnosis and exclusion of emphysema. Am J Med 82:998–1006.

    PubMed  CAS  Google Scholar 

  83. Greene R (1978) “Saber-sheath” trachea: Relation to chronic obstructive pulmonary disease. AJR 130:441–445.

    PubMed  CAS  Google Scholar 

  84. Greene R, Lechner GL (1975) “Saber-sheath” trachea: A clinical and functional study of marked coronal narrowing of the intrathoracic trachea. Radiology 115:265–268.

    PubMed  Google Scholar 

  85. Reich SB, Weinshelbaum A, Yee J (1985) Correlation of radiographic measurements and pulmonary function tests in chronic obstructive pulmonary disease. AJR 144:695–699.

    PubMed  CAS  Google Scholar 

  86. Thurlbeck WM, Müller NL (1994) Emphysema: Definition, imaging, and quantification. AJR 163:1017–1025.

    PubMed  CAS  Google Scholar 

  87. Nicklaus TM, Stowell DW, Christiansen WR, et al. (1966) The accuracy of the roentgenologic diagnosis of chronic pulmonary emphysema. Am Rev Respir Dis 93:889–899.

    PubMed  CAS  Google Scholar 

  88. Miller RR, Müller NL, Vedal S, et al. (1989) Limitations of computed tomography in the assessment of emphysema. Am Rev Respir Dis 139:980–983.

    PubMed  CAS  Google Scholar 

  89. Bergin C, Müller N, Nichols DM, et al. (1986) The diagnosis of emphysema. A computed tomographic-pathologic correlation. Am Rev Respir Dis 133:541–546.

    PubMed  CAS  Google Scholar 

  90. Müller NL, Staples CA, Miller RR, et al. (1988) “Density mask”. An objective method to quantitate emphysema using computed tomography. Chest 94:782–787.

    PubMed  Google Scholar 

  91. Gevenois PA, De Vuyst P, Sy M, et al. (1996) Pulmonary emphysema: Quantitative CT during expiration. Radiology 199:825–829.

    PubMed  CAS  Google Scholar 

  92. Gevenois PA, Yernault JC (1995) Can computed tomography quantify pulmonary emphysema? Eur Respir J 8:843–848.

    PubMed  CAS  Google Scholar 

  93. Kuwano K, Matsuba K, Ikeda T, et al. (1990) The diagnosis of mild emphysema. Correlation of computed tomography and pathology scores. Am Rev Respir Dis 141:169–178.

    PubMed  CAS  Google Scholar 

  94. Müller NL, Thurlbeck WM (1996) Thin-section CT, emphysema, air trapping, and airway obstruction [editorial; comment]. Radiology 199:621–622.

    PubMed  Google Scholar 

  95. Morrison NJ, Abboud RT, Müller NL, et al. (1990) Pulmonary capillary blood volume in emphysema. Am Rev Respir Dis 141:53–61.

    PubMed  CAS  Google Scholar 

  96. Gelb A, Schein M, Kuei J, et al. (1993) Limited contribution of emphysema in advanced chronic obstructive pulmonary disease. Am Rev Respir Dis 147:1157–1163.

    PubMed  CAS  Google Scholar 

  97. Gelb AF, Hogg JC, Müller NL, et al. (1996) Contribution of emphysema and small airways in COPD. Chest 109:353–359.

    PubMed  CAS  Google Scholar 

  98. Eda S, Kubo K, Fujimoto K, et al. (1997) The relations between expiratory chest CT using helical CT and pulmonary function tests in emphysema. Am J Respir Crit Care Med 155:1290–1294.

    PubMed  CAS  Google Scholar 

  99. Haraguchi M, Shimura S, Hida W, et al. (1998) Pulmonary function and regional distribution of emphysema as determined by high-resolution computed tomography. Respiration 65:125–129.

    PubMed  CAS  Google Scholar 

  100. Kazerooni E, Martinez F, Quint L, et al. (1996) Quantitative helical CT indices of emphysema as predictors of outcome after lung volume reduction surgery. Radiology 201(P):298.

    Google Scholar 

  101. Kauczor HU, Heussel CP, Fischer B, et al. (1998) Assessment of lung volumes using helical CT at inspiration and expiration: Comparison with pulmonary function tests. AJR 171:1091–1095.

    PubMed  CAS  Google Scholar 

  102. Slone RM, Gierada DS, Yusen RD (1998) Preoperative and postoperative imaging in the surgical management of pulmonary emphysema. Radiol Clin North Am 36:57–89.

    PubMed  CAS  Google Scholar 

  103. Slone RM, Pilgram TK, Gierada DS, et al. (1997) Lung volume reduction surgery: Comparison of preoperative radiologic features and clinical outcome [see comments]. Radiology 204:685–693.

    PubMed  CAS  Google Scholar 

  104. Kazerooni EA, Curtis JL, Paine R, et al. (1998) Long-term outcome after bilateral apical lung volume reduction surgery (LVRS) via median sternotomy: Predictive value of quantitative helical CT Chronic Obstructive Pulmonary Disease analysis (QCT) and physiologic severity of hyperinflation. Radiology 209(P):257.

    Google Scholar 

  105. Sciurba F (1997) Early and long-term functional outcomes following lung volume reduction surgery. Clin Chest Med 18:259–276.

    PubMed  CAS  Google Scholar 

  106. McKenna RJ Jr, Brenner M, Fischel RJ, et al. (1997) Patient selection criteria for lung volume reduction surgery. J Thorac Cardiovasc Surg 114:957–964; discussion 964–957.

    PubMed  Google Scholar 

  107. Mettler FA, Guiberteau MJ (1997) Respiratory system. In Mettler FA, Guiberteau MJ (eds) Essentials of nuclear medicine, 3rd edn. WB Saunders, Philadelphia, pp 167–170.

    Google Scholar 

  108. Jamadar DA, Kazerooni EA, Martinez FJ, (1999) Qualitative ventilation-perfusion scintigraphy and SPECT imaging in the evaluation of lung volume reduction surgery candidates: Description and prediction of clinical outcome. Eur J Nucl Med 26:734–42.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag London Limited

About this chapter

Cite this chapter

Kazerooni, E.A., Flaherty, K.R., Martinez, F.J. (2001). Chronic Obstructive Pulmonary Disease. In: Sperber, M. (eds) Radiologic Diagnosis of Chest Disease. Springer, London. https://doi.org/10.1007/978-1-4471-0693-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-0693-7_16

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1179-5

  • Online ISBN: 978-1-4471-0693-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics