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Genotype Phenotype Correlation in Familial Adenomatous Polyposis

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Hereditary Colorectal Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA,volume 5))

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Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant inherited syndrome whereby affected individuals can have less than 100 adenomas (Attenuated Adenomatous Polyposis) to thousands of adenomas (Classic Familial Adenomatous Polyposis). The syndrome is also characterized by extracolonic manifestations such as fundic gland polyps, duodenal adenomas, desmoids tumors, thyroid cancer, osteomas, and congenital hypertrophied pigmented retinal epithelium among others. There are genotype and phenotype correlations noted in and these will be discussed in this chapter.

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Authors and Affiliations

  1. The University of Texas, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Miguel A. Rodriguez-Bigas

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  1. Miguel A. Rodriguez-Bigas
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Correspondence to Miguel A. Rodriguez-Bigas .

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Editors and Affiliations

  1. M.D. Anderson Cancer Center, Surgical Oncology, The University of Texas, Holcombe Blvd. 1515, Houston, 77030, Texas, USA

    Miguel A. Rodriguez-Bigas

  2. Associate Professor of Surgery, Brazilian Registry of Inherited, Colorec, University of São Paulo Medical School, Sao Paulo, Brazil

    Raul Cutait

  3. M.D. Anderson Cancer Center, Gastroenterology, The University of Texas, Houston, 77030, Texas, USA

    Patrick M. Lynch

  4. Cancer Research UK London Research Insti, Molecular and Population Genetics Labora, London, United Kingdom

    Ian Tomlinson

  5. Medical Center, Gastroenterology, Leiden University, Leiden, 2333 AA, Netherlands

    Hans F.A. Vasen

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Rodriguez-Bigas, M.A. (2010). Genotype Phenotype Correlation in Familial Adenomatous Polyposis. In: Rodriguez-Bigas, M., Cutait, R., Lynch, P., Tomlinson, I., Vasen, H. (eds) Hereditary Colorectal Cancer. M.D. Anderson Solid Tumor Oncology Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6603-2_10

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  • DOI: https://doi.org/10.1007/978-1-4419-6603-2_10

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-6602-5

  • Online ISBN: 978-1-4419-6603-2

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