Skip to main content
SpringerLink
Log in

Antimicrobial Resistance and Therapeutic Alternatives

  • Chapter
  • First Online:
Acinetobacter Biology and Pathogenesis

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

  • 881 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bergogne-Bérézin, E. and Towner, K. J. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148–165.

    PubMed  Google Scholar 

  • Bernabeu-Wittel, M., Pichardo, C., García-Curiel, A., Pachón-Ibáñez, M. E., Ibáñez-Martínez, J., Jiménez-Mejías, M. E. and Pachón, J. 2005. Pharmacokinetc/pharmacodynamic assessment of the in-vivo efficacy of imipenem alone or in combination with amikacin for the treatment of experimental multiresistant Acinetobacter baumannii pneumonia. Clin. Microbiol. Infect. 11:319–325.

    Article  CAS  Google Scholar 

  • Betriu, C., Rodriguez-Avial, I., Gómez, M., Culebras, E., López, F., Alvarez, J., Picazo, J.J. and the Spanish Tigecycline Group. 2006. Antimicrobial activity of tigecycline against clinical isolates of Spanish medical centers: second multicenter study. Diagn. Microbiol. Infect. Dis. 56:437–444.

    Article  PubMed  CAS  Google Scholar 

  • Biendo, M., Laurans, G., Lefebvre, J. F., Daoudi, F. and Eb, F. 1999. Epidemiological study of an Acinetobacter baumannii outbreak by using a combination of antibiotyping and ribotyping. J. Clin. Microbiol. 37:2170–2175.

    PubMed  CAS  Google Scholar 

  • Blot, S., Vandewoude, K. and Colardyn, F. 2003. Nosocomial bacteremia involving Acinetobacter baumannii in critically ill patients: a matched cohort study. Int. Care Med. 29:471–475.

    Google Scholar 

  • Braunstein, A., Papo, N. and Shai, Y. 2004. In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria. Antimicrob. Agent Chemother. 48:3127–3129.

    Article  CAS  Google Scholar 

  • Buisson, Y., Tran Van Nhieu, G. and Ginot, L. 1990. Nosocomial outbreaks due to amikacin-resistant tobramycin-sensitive Acinetobacter species: correlation with amikacin usage. J. Hosp. Infect. 15:83–93.

    Article  PubMed  CAS  Google Scholar 

  • Chen, S. F., Chang, W. N., Lu, C. H., Chuang, Y. C., Tsai, H. H., Tsai, N. W., Chang, H. W., Lee, P. Y., Chien, C. C. and Huang, C. R. 2005. Adult Acinetobacter meningitis and its comparison with non-Acinetobacter gram-negative bacterial meningitis. Acta Neurol. Taiwan 14:131–137.

    PubMed  Google Scholar 

  • Cisneros, J. M., Reyes, M. J., Pachon, J., Becerril, B., Caballero, F. J., Garcia-Garmendia, J. L., Ortiz, C. and Cobacho, A. R. 1996. Bacteremia due to Acinetobacter baumannii: epidemiology, clinical findings, and prognostic features. Clin. Infect. Dis. 22:1026–1032.

    Article  PubMed  CAS  Google Scholar 

  • Corbella, X., Pujol, M., Ayats, J., Sendra, M., Ardanuy, C., Dominguez, M. A., Linares, J., Ariza, J. and Gudiol, F. 1996. Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumannii. Clin. Infect. Dis. 23:329–334.

    Article  PubMed  CAS  Google Scholar 

  • Corbella, X., Ariza, J., Ardanuy, C., Vuelta, M., Tubau, F., Sora, M., Pujol, M., Gudiol, F. 1998. Efficacy of sulbactam alone and in combination with ampicillin in nosocomial infections caused by multiresistant Acinetobacter baumannii. J. Antimicrob. Chemother. 42:793–802.

    Article  PubMed  CAS  Google Scholar 

  • Da Silva, G. J., Correia, M., Vital, C., Ribeiro, G., Sousa, J. C., Leitao, R., Peixe, L. and Duarte, A. 2002. Molecular characterization of bla(IMP-5), a new integron-borne metallo-beta-lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal. FEMS Microbiol. Lett. 215:33–39.

    Article  PubMed  Google Scholar 

  • Devaud, M., Kayser, F. H. and Bachi, B. 1982. Transposon-mediated multiple antibiotic resistance in Acinetobacter strains. Antimicrob. Agents Chemother. 22:323–329.

    PubMed  CAS  Google Scholar 

  • De Vegas, E. Z., Nieves, B., Araque, M., Velasco, E., Ruiz, J. and Vila, J. 2006. Outbreak of infection with Acinetobacter strain RUH 1139 in an intensive care unit. Infect. Control Hosp. Epidemiol. 27:397–403.

    Article  PubMed  Google Scholar 

  • Elisha, B. G. and Stein, L.M. 1991. The use of molecular techniques for the location and characterization of antibiotic resistance genes in clinical isolates of Acinetobacter. In The Biology of Acinetobacter, eds. K.J. Towner, E. Bergogne-Bérézin and C.A. Fewson. New York: Plenum Publishing Corp.

    Google Scholar 

  • Falagas, M.E., Bliziotis, I.A., Kasiakou, S.K., Samonis, G., Athanassopoulou, P. and Michalopoulos, A. 2005. Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria. BMC Infect. Dis. 5:24–30.

    Article  PubMed  Google Scholar 

  • Falagas, M. E., Kopterides, P. and Siempos, I. I. 2006. Attributable mortality of Acinetobacter baumannii infection among critically ill patients. Clin. Infect. Dis. 43: (Suppl.) S1–S39.

    Article  PubMed  Google Scholar 

  • Fagon, J. Y., Chastre, J., Hance, A. J., Montravers, P., Novara, A. and Gibert, C. 1993. Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am. J. Med. 94:281–288.

    Article  PubMed  CAS  Google Scholar 

  • Fagon, J. Y., Chastre, J., Domart, Y., Trouillet, J. L. and Gibert, C. 1996. Mortality due to ventilator-associated pneumonia or colonization with Pseudomonas or Acinetobacter species: assessment by quantitative culture of samples obtained by a protected specimen brush. Clin. Infect. Dis. 23:538–542.

    Article  PubMed  CAS  Google Scholar 

  • Fernández-Cuenca, F., Pascual, A., Ribera, A., Vila, J., Bou, G., Cisneros, J. M., Rodríguez-Baño, J., Pachón, J., Martínez-Martínez, L. and Grupo de Estudio de Infección Hospitalaria (GEIH). 2004. Diversidad clonal y sensibilidad a los antimicrobianos de Acinetobacter baumannii aislados en hospitales españoles. Estudio multicéntrico nacional: proyecto GEIH-Ab 2000. Enferm. Infecc. Microbiol. Clín. 22:267–271.

    Article  PubMed  Google Scholar 

  • Fournier, P. E. and Richet, H. 2006. The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin. Infect. Dis. 42:692–699.

    Article  PubMed  Google Scholar 

  • Fournier, P. E., Vellenet, D., Barbe, V., Audic, S., Ogata, H., Poirel, L., Richet, H., Robert, C., Mangenot, S., Abergel, C., Nordmann, P., Weissenbach, J., Raoult, D. and Claverie, J. M. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet. 2:62–72.

    Article  CAS  Google Scholar 

  • Garnacho, J., Sole-Violan, J., Sa-Borges, M., Diaz, E. and Rello, J. 2003. Clinical impact of pneumonia caused by Acinetobacter baumannii in intubated patients: a matched cohort study. Crit. Care Med. 31:2478–2482.

    Article  PubMed  Google Scholar 

  • Garnacho-Montero, J., Ortiz-Leyva, C., Jiménez-Jiménez, F. J., Barrero-Almodóvar, A. E., García-Garmendia, J. L., Bernabeu-Wittel, M., Gallego-Lara, S. L. and Madrazo-Osuna, J. 2003. Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP. Clin. Infect. Dis. 36:1111–1118.

    Article  PubMed  CAS  Google Scholar 

  • Garnacho-Montero, J., Ortiz-Leyba, C., Fernández-Hinojosa, E., Aldabó-Pallás, T., Cayuela, A., Márquez-Vácaro, J. A., García-Curiel, A. and Jiménez-Jiménez, F. J. 2005. Acinetobacter baumannii ventilator-associated pneumonia: epidemiological and clinical findings. Int. Care Med. 31:649–655.

    Article  Google Scholar 

  • Getchell-White, S. I., Donowitz, L. G. and Groschel, D. H. 1989. The inanimate environment of an intensive care unit as a potential source of nosocomial bacteria: evidence for long survival of Acinetobacter calcoaceticus. Infect. Control Hosp. Epidemiol. 10:402–407.

    Article  PubMed  CAS  Google Scholar 

  • Gkrania-Klotsas, E. and Hershow, R. C. 2006. Colonization or infection with multidrug resistant Acinetobacter baumannii may be an independent risk factor for increased mortality. Clin. Infect. Dis. 43:1224–1225.

    Article  PubMed  Google Scholar 

  • Gleeson, T., Petersen, K. and Mascola, J. 2005. Successful treatment of Acinetobacter meningitis with meropenm and rifampicin. J. Antimicrob. Chemother. 56:602–603.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, F. W., Labigne-Roussel, A., Gerbaud, G., Carlier, C., Collatz, E. and Courvalin, P. 1983. Transferable plasmid-mediated antibiotic resistance in Acinetobacter. Plasmid 10:138–147.

    Article  PubMed  CAS  Google Scholar 

  • Gombac, F., Riccio, M. L., Rossolini, G. M., Lagatolla, C., Tonin, E., Monti-Bragadin, C., Lavenia, A. and Dolzani, L. 2002. Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian Hospitals Reveals a Limited Diversity of Gene Cassette Arrays. Antimicrob. Agents Chemother. 46:3665–3668.

    Article  PubMed  CAS  Google Scholar 

  • Grehn, M. and von Graevenitz, A. 1978. Search for Acinetobacter calcoaceticus subsp. anitratus: enrichment of fecal samples. J. Clin. Microbiol. 8:342–343.

    PubMed  CAS  Google Scholar 

  • Grupper, M., Sprecher, H., Mashiach, T. and Finkelstein, R. 2007. Attributable mortality of nosocomial Acinetobacter bacteremia. Infect. Control Hosp. Epidemiol. 28:293–298.

    Article  PubMed  Google Scholar 

  • Higgins, P. G., Wisplinghoff, H., Stefanik, D. and Seifert, H. 2004. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii. J. Antimicrob. Chemother. 54:821–823.

    Article  PubMed  CAS  Google Scholar 

  • Huovinen, P., Sundstrom, L., Swedberg, G. and Skold, O. 1995. Trimethoprim and sulfonamide resistance. Antimicrob. Agents Chemother. 39:279–289.

    PubMed  CAS  Google Scholar 

  • Hsueh, P. R., Teng, L. J., Chen, C. Y., Chen, W. H., Yu, C. J., Ho, S. W. and Luh, K. T. 2002. Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan. Emerg. Infect. Dis. 8:827–832.

    PubMed  CAS  Google Scholar 

  • Jiménez-Mejías, M. E., Pachón, J., Becerril, B., Palomino-Nicas, J., Rodriguez-Cobacho, A. and Revuelta, M. 1997. Treatment of multidrug-resistant Acinetobacter baumannii meningitis with ampicillin/sulbactam. Clin. Infect. Dis. 24:932–935.

    Article  PubMed  Google Scholar 

  • Jiménez-Mejías, M. E., Pichardo-Guerrero, C., Márquez-Rivas, F. J., Martín-Lozano, D., Prados, T. and Pachón, J. 2002. Cerebrospinal fluid penetration and pharmacokinetic/pharmacodynamic parameters of intravenously administered colistin in a case of multidrug-resistant Acinetobacter baumannii meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 21:212–214.

    Article  PubMed  Google Scholar 

  • Kuo, L. C., Lai, C. C., Liao, C. H., Hsu, C. K., Chang, Y. L., Chang, C. Y. and Hsueh, P. R. 2007. Multidrug-resistant Acinetobacter baumannii bacteraemia: clinical features, antimicrobial therapy and prognosis. Clin. Microbiol. Infect. 13:196–198.

    Article  PubMed  CAS  Google Scholar 

  • Kwon, K. T., Oh, W. S., Song, J. H., Chang, H. H., Jung, S. I., Kim, S. W., Ryu, S. Y., Heo, S. T., Jung, D. S., Rhee, J. Y., Shin, S. Y., Ko, K. S., Peck, K.R. and Lee, N. Y. 2007. Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia. J. Antimicrob. Cemother. 59:525–530.

    Article  CAS  Google Scholar 

  • Lee, K., Yum, J. H., Yong, D., Lee, H. M., Kim, H. D., Docquier, J. D., Rossolini, G. M. and Chong, Y. 2005. Novel acquired Metallo-ß-Lactamase gene, bla SIM-1, in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea. Antimicrob. Agents Chemother. 49: 4485–4491.

    Article  PubMed  CAS  Google Scholar 

  • Levin, A. S., Levy, C. E., Manrique, A. E., Medeiros, E. A. and Costa, S. F. 2003. Severe nosocomial infections with imipenem-resistant Acinetobacter baumannii treated with ampicillin/sulbactam. Int. J. Antimicrob. Agents 21:58–62.

    Article  PubMed  CAS  Google Scholar 

  • Linden, P. K. and Paterson, D. L. 2006. Parenteral and inhaled colistin for treatment of ventilator-associated pneumonia. Clin. Infect. Dis. 43:S89–S94.

    Article  PubMed  CAS  Google Scholar 

  • Magnet, S., Courvalin, P. and Lambert, T. 2001. Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother. 45:3375–3380.

    Article  PubMed  CAS  Google Scholar 

  • Marchand, I., Damier-Piolle, L., Courvalin, P. and Lambert, T. 2004. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48:3298–3304.

    Article  PubMed  CAS  Google Scholar 

  • Martí, S., Fernández-Cuenca, F., Pascual, A., Ribera, A., Rodríguez-Baño, J., Bou, G., Cisneros, J. M., Pachón, J., Martínez-Martínez, L., Vila, J. and Grupo de Estudio de Infección Hospitalaria. 2006. Prevalencia de los genes tetA y tetB como mecanismo de resistencia a tetraciclina y minociclina en aislamientos clínicos de Acinetobacter baumannii. Enferm. Infecc. Microbiol. Clin. 24:77–80.

    Article  PubMed  Google Scholar 

  • McDonald, L. C. 2006. Trends in antimicrobial resistance in health care-associated pathogens and effect on treatment. Clin. Infect. Dis. 42:S65–S71.

    Article  PubMed  Google Scholar 

  • Montero, A., Ariza, J., Corbella, X., Doménech, A., Cabellos, C., Ayats, J., Tubau, F., Borraz, C. and Gudiol, F. 2004. Antibiotic combinations for serious infections caused by carbapenem-resistant Acinetobacter baumannii in a mouse pneumonia model. J. Antimicrob. Chemother. 54:1085–1091.

    Article  PubMed  CAS  Google Scholar 

  • Montero, A., Ariza, J., Corbella, X., Doménech, A., Cabellos, C., Ayats, J., Tubau, F., Ardanuy, C. and Gudiol, F. 2002. Efficacy of colistin versus β-lactams, aminoglycosides, and rifampin as monotherapy in a mouse model of pneumonia caused by multiresistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 46:1946–1952.

    Article  CAS  Google Scholar 

  • Motaouakkil, S., Charra, B., Hachimi, A., Nejmi, H., Benslama, A., Elmdaghri, N., Belabbes, H. and Benbachir, M. 2006. Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii. J. Infect. 53:274–278.

    Article  PubMed  Google Scholar 

  • Musa, E. K., Desai, N. and Casewell, M. W. 1990. The survival of Acinetobacter calcoaceticus inoculated on fingertips and on formica. J. Hosp. Infect. 15:219–227.

    Article  PubMed  CAS  Google Scholar 

  • Nagano, N., Nagano, Y., Cordevant, C., Shibata, N. and Arakawa, Y. 2004. Nosocomial transmisión of CTX-M-2 β-lactamase producing Acinetobacter baumannii in a neurosurgery ward. J. Clin. Microbiol. 42:3978–3984.

    Article  PubMed  CAS  Google Scholar 

  • Navia, M., Ruiz, J. and Vila, J. 2002. Characterization o fan integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii. Microb. Drug Resist. 8:261–265.

    Article  PubMed  CAS  Google Scholar 

  • Nemec, A., Dolzani, L., Brisse, S., van den Broek, P. and Dijkshoorn, L. 2004. Diversity of aminoglycoside-resistance genes and their association with class 1 integrons among strains of pan-European Acinetobacter baumannii clones. J. Med. Microbiol. 53:1233–1240.

    Article  PubMed  CAS  Google Scholar 

  • Ng, J., Gosbell, I. B., Kelly, J. A., Boyle, M. J. and Ferguson, J. K. 2006. Cure of multiresistant Acinetobacter baumannii central nervous infections with intraventricular or intrathecal colistin: case series and literature review. J. Antimicrob. Chemother. 58:1078–1081.

    Article  PubMed  CAS  Google Scholar 

  • Obana, Y., Nishino, T. and Tanino, T. 1985. In vitro and in vivo activities of antimicrobial agents against Acinetobacter calcoaceticus. J. Antimicrob. Chemother. 15:441–448.

    Article  PubMed  CAS  Google Scholar 

  • Owen, R. J., Li, J., Nation, R. L. and Spelman, D. 2007. In vitro pharmacodynamics of colistin against Acinetobacter baumannii clinical isolates. J. Antimicrob. Chemother. 59:473–477.

    Article  PubMed  CAS  Google Scholar 

  • Pachón-Ibáñez, M. E., Jiménez-Mejías, M. E., Pichardo, C., Llanos, A. C. and Pachón, J. 2004. Antimicrobial activity of tigecycline (GAR-936) again multiresistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 48:4479–4481.

    Article  PubMed  Google Scholar 

  • Pachón-Ibáñez, M. E., Docobo-Pérez, F., Jiménez-Mejías, M. E., Pichardo, C., García-Curiel, A. and Pachón, J. 2005. Efficacy of rifampin, imipenem, and sulbactam in monotherapy and combination, in the experimental pneumonia caused by panresistant Acinetobacter baumannii. Clin. Microbiol. Infect. 11(Suppl. 2):868–873.

    Google Scholar 

  • Pachón-Ibáñez, M. E., Fernández-Cuenca, F., Docobo-Pérez, F., Pachón, J. and Pascual, A. 2006. Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia model, using rifampicin associated to imipenem or sulbactam. J. Antimicrob. Chemother. 58:689–692.

    Article  PubMed  Google Scholar 

  • Pantopoulou, A., Giamarellos-Bourboulis E. J., Raftogannis, M., Tsaganos, T., Dontas, I., Koutoukas, P., Baziaka, F., Giamarellou, H. and Perrea, D. 2007. Colistin offers prolonged survival in experimental infection by multiresistant Acinetobacter baumannii: the significance of co-administration of rifampicina. Int. J. Antimicrob. Agents 29:51–55.

    Article  PubMed  CAS  Google Scholar 

  • Peleg, A. Y., Potoski, B. A., Rea, R., Adams, J., Sethi, J., Capitano, B., Husain, S., Kwak, E. J., Bhat, S. V. and Paterson, D. L. 2007. Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report. J. Antimicrob. Chemother. 59:128–131.

    Article  PubMed  CAS  Google Scholar 

  • Petrosillo, N., Chinello, P., Proietti, M. F., Cecchini, L., Masala, M., Franchi, C., Venditti, M., Sposito, S. and Nicastri, E. 2005. Combined colistin and rifampicin therapy for carbapenem-resistant Acinetobacter baumannii infections: clinical outcome and adverse events. Clin. Microbiol. Infect. 11:682–683.

    Article  PubMed  CAS  Google Scholar 

  • Plachouras, D., Giamarellos-Bourboulis, E. J., Kentepozidis, N., Baziaka, F., Karagianni, V. and Giamarellou, H. 2006. In vitro postantibiotic effect of colistin on multidrug-resistant Acinetobacter baumannii. Diagn. Microbiol. Infect. Dis. Dec 21; [Epub ahead of print].

    Google Scholar 

  • Poirel, L., Karim, A., Mercat, A., Le Thomas, I., Vahaboglu, H., Richard, C. and Nordmann, P. 1999. Extended-spectrum β-lactamase-producing strain of Acinetobacter baumannii isolated from a patient in France. J. Antimicrob. Chemother. 43:157–165.

    Google Scholar 

  • Poirel, L., Menuteau, O., Agoli, N., Cattoen, C. and Nordmann, P. 2003. Outbreak of extended-spectrum β-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital. J. Clin. Microbiol. 41:3542–3547.

    Article  PubMed  CAS  Google Scholar 

  • Poirel, L. and Nordmann, P. 2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect. 12:826–836.

    Article  PubMed  CAS  Google Scholar 

  • Rahal, J. J. 2006. Novel antibiotics combinations against infections with almost completely resistant Pseudomonas aeruginosa and Acinetobacter species. Clin. Infect. Dis. 43:S95–S99.

    Article  PubMed  CAS  Google Scholar 

  • Ribera, A., Ruiz, J., Jiménez de Anta, M. T. and Vila, J. 2002. Effect o fan efflux pump inhibitor on the MIC of nalidixic acid for Acinetobacter baumannii and Stenotrophomonas maltophilia. J. Antimicrob. Chemother. 49:697–702.

    Article  PubMed  CAS  Google Scholar 

  • Ribera, A., Roca, I., Ruiz, J., Gibert, I. and Vila, J. 2003. Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii. J. Antimicrob. Chemother. 52:477–480.

    Article  PubMed  CAS  Google Scholar 

  • Ribera, A., Vila, J., Fernández-Cuenca, F., Martínez-Martínez, L., Pascual, A., Beceiro, A., Bou, G., Cisneros, J. M., Pachón, J. and Rodríguez-Baño, J. 2004. Type 1 Integrons in Epidemiologically Unrelated Acinetobacter baumannii Isolates Collected at Spanish Hospitals. Antimicrob. Agents Chemother. 48: 364–365.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, M. C. 2005. Update on acquired tetracycline resistance genes. FEMS Microbiol Lett. 245:195–203.

    Article  PubMed  CAS  Google Scholar 

  • Rodríguez-Baño, J., Cisneros, J. M., Fernandez-Cuenca, F., Ribera, A., Vila, J., Pascual, A., Martinez-Martinez, L., Bou, G., Pachon, J. and the Spanish Group for Nosocomial Infection (GEIH). 2004. Clinical features and epidemiology of Acinetobacter baumannii colonization and infection in Spanish hospitals. Infect. Control Hosp. Epidemiol. 25:819–824.

    Article  PubMed  Google Scholar 

  • Rodríguez-Hernández, M. J., Pachón, J., Pichardo, C., Cuberos, L., Ibáñez-Martínez, J., García-Curiel, A., Caballero, F. J., Moreno, I. and Jiménez-Mejías, M. E. 2000. Imipenem, doxycycline and amikacin in monotherapy and in combination in Acinetobacter baumannii experimental pneumonia. J. Antimicrob. Chemother. 45:493–501.

    Article  PubMed  Google Scholar 

  • Rodríguez-Hernández, M. J., Jiménez-Mejias, M. E., Pichardo, C., Cuberos, L., García-Curiel, A. and Pachón, J. 2004. Colistin efficacy in an experimental endocarditis model caused by Acinetobacter baumannii. Clin. Microbiol. Infect. 10:581–584.

    Article  PubMed  Google Scholar 

  • Rodríguez-Hernández, M. J., Saugar, J., Docobo-Perez, F., de la Torre, B. G., Pachón-Ibáñez, M. E., Garcia-Curiel, A., Fernández-Cuenca, F., Andreu, D., Rivas, L. and Pachón, J. 2006. Studies on the antimicrobial activity of cecropin A-melittin hybrid peptides in colistin-resistant clinical isolates of Acinetobacter baumannii. J. Antimicrob. Chemother. 58:95–100.

    Article  PubMed  Google Scholar 

  • Rosenthal, S. and Tager, I. B. 1975. Prevalence of gram-negative rods in the normal pharyngeal flora. Ann. Intern. Med. 83:355–357.

    PubMed  CAS  Google Scholar 

  • Ruiz, J., Navia, M. M., Casals, C., Sierra, J. M., Jiménez De Anta, M. T. and Vila, J. 2003. Integron-mediated antibiotic multiresistance in Acinetobacter baumannii clinical isolates from Spain. Clin. Microbiol. Infect. 9:907–911.

    Article  CAS  Google Scholar 

  • Ruzin, A., Keeney, D. and Bradfort, P. A. 2007. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. J. Antimicrob. Chemother. 60:1018–1029.

    Google Scholar 

  • Saballs, M., Pujol, M., Tubau, F., Peña, C., Montero, A., Dominguez, M. A., Gudiol, F. and Ariza, J. 2006. Rifampicin/imipenem combination in the treatment of carbapenem-resistant Acinetobacter baumannii infections. J. Antimicrob. Chemother. 58:697–700.

    Article  PubMed  CAS  Google Scholar 

  • Sato, K. and Nakae, T. 1991. Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance. J. Antimicrob. Chemother. 28:35–45.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, K. J., Rather, P. N., Hare, R. S. and Miller, G. H. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationship of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57:138–163.

    PubMed  CAS  Google Scholar 

  • Seifert, H., Baginski, R., Schulze, A. and Pulverer, G. 1993. Antimicrobial susceptibility of Acinetobacter species. Antimicrob. Agents Chemother. 37:750–753.

    PubMed  CAS  Google Scholar 

  • Seifert, H., Stefanik, D. and Wisplinghoff, H. 2006. Comparative in vitro activities of tigecycline and 11 other antimicrobial agents against 215 epidemiologically defined multidrug-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 58:1099–1100

    Article  PubMed  CAS  Google Scholar 

  • Somerville, D. A. and Noble, W. C. 1970. A note on the gram-negative bacilli of human skin. Eur. J. Clin. Biol. Res. 40:669–670.

    Google Scholar 

  • Su, X. Z., Chen, J., Mizushima, T., Kuroda, T. and Tsuchira, T. 2005. AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob. Agents Chemother. 49:4362–4364.

    Article  PubMed  CAS  Google Scholar 

  • Sunenshine, H. R., Wright, M. O., Maragakis, L. L., Harris, A. D., Song, X., Hebden, J., Cosgrove, S. E., Anderson, A., Carnell, J., Jernigan, D. B., Kleinbaum, D. G., Perl, T. M., Standiford, H. C. and Srinivasan, A. 2007. Multidrug resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg. Infect. Dis. 13:97–103.

    Article  PubMed  Google Scholar 

  • Traub, W. H. and Spohr, M. 1989. Antimicrobial drug susceptibility of clinical isolates of Acinetobacter species (A. baumannii, A. haemolyticus, genospecies 3 and genospecies 6). Antimicrob. Agents Chemother. 33:1617–1619.

    PubMed  CAS  Google Scholar 

  • Turton, J. F., Kaufmann, M. E., Glover, J., Coelho, J. M., Warner, M., Pike, R. and Pitt, T. L. 2005. Detection and typing of integrons in epidemic strains of Acinetobacter baumannii found in the United Kingdom. J. Clin. Microbiol. 43:3074–3082.

    Article  PubMed  CAS  Google Scholar 

  • Vila, J., Marcos, F., Marco, M. A., Abadía, S., Vergara, Y., Reig, R., Gómez-Lus, R. and Jiménez de Anta, M. T. 1993. In vitro antimicrobial production of β-lactamases, aminoglycoside-modifying enzymes, and chloramphenicol acetyltransferase by and susceptibility of clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 37:138–141.

    PubMed  CAS  Google Scholar 

  • Vila, J., Ruiz, J., Goñi, P., Marcos, M. A. and Jimenez de Anta, M. T. 1995. Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 39:1201–1203.

    PubMed  CAS  Google Scholar 

  • Vila, J., Navia, M., Ruiz, J. and Casals, C. 1997. Cloning and nucleotide sequence análisis of a gene encoding a OXA-derived β-lactamase in Acinetobacter baumannii. Antimicrob. Agents Chemother. 41:2757–2759.

    PubMed  CAS  Google Scholar 

  • Vila, J., Goñi, P. and Jimenez de Anta, M. T. 1997. Quinolone resistant mutations in the topoisomerase IV parC gene of Acinetobacter baumannii. J. Antimicrob. Chemother. 39:757–762.

    Article  PubMed  CAS  Google Scholar 

  • Vila, J., Ruiz, J., Navia, J., Becerril, J., Garcia, I., Perea, S., López-Hernández, I., Alamo, I., Ballester, F., Planes, A. M., Martínez-Beltran, J. and Jiménez de Anta, M. T. 1999. Spread of a mikacin resistance in Acinetobacter baumannii isolated in Spain is due toa n epidemia strain. J. Clin. Microbiol. 37:758–761.

    PubMed  CAS  Google Scholar 

  • Vila, J. 2005. Fluoroquinolone resistance. In Frontiers in Antimicrobial Resistance: A tribute to Stuart B. Levy, eds. D.G. White, M.N. Alekshun and P.F. McDermott, pp. 41–52. Washington, DC: ASM Press

    Google Scholar 

  • Vila, J., Martí, S. and Sánchez-Céspedes, J. 2007. Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii. J. Antimicrob. Chemother. 59:1223–1229.

    Google Scholar 

  • Wolff, M., Joly-Guillou, M. L., Farinotti, R. and Carbon, C. 1999. In vivo efficacies of combinations of β-lactams, β-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model. Antimicrob. Agents Chemother. 43:1406–1411.

    PubMed  CAS  Google Scholar 

  • Wood, G. C., Hanes, S. D., Croce, M. A., Fabian, T. C. and Boucher, B. A. 2002. Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of Acinetobacter baumannii ventilator-associated pneumonia. Clin. Infect. Dis. 34:1425–1430.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Microbiology, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain

    Jordi Vila & Jerónimo Pachón

Authors
  1. Jordi Vila
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jerónimo Pachón
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Paris, France

    Eugénie Bergogne-Bérézin (Editor-in-Chief of Antibiotiques) (Editor-in-Chief of Antibiotiques)

  2. University of South Florida, College of Medicine, Tampa, Florida, USA

    Herman Friedman

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Vila, J., Pachón, J. (2008). Antimicrobial Resistance and Therapeutic Alternatives. In: Bergogne-Bérézin, E., Friedman, H., Bendinelli, M. (eds) Acinetobacter Biology and Pathogenesis. Infectious Agents and Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77944-7_11

Download citation

Publish with us

Policies and ethics

Search

Navigation