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Cerebrospinal Fluid Penetration and Pharmacokinetic/Pharmacodynamic Parameters of Intravenously Administered Colistin in a Case of Multidrug-Resistant Acinetobacter baumannii Meningitis

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Abstract

Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.

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Authors and Affiliations

  1. Service of Infectious Diseases, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain

    M. Jiménez-Mejías, C. Pichardo-Guerrero, D. Martín-Lozano & J. Pachón

  2. Service of Neurosurgery, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain

    F. Márquez-Rivas

  3. Service of Microbiology, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain

    T. Prados

Authors
  1. M. Jiménez-Mejías
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  2. C. Pichardo-Guerrero
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  3. F. Márquez-Rivas
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  4. D. Martín-Lozano
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  5. T. Prados
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  6. J. Pachón
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Jiménez-Mejías, M., Pichardo-Guerrero, C., Márquez-Rivas, F. et al. Cerebrospinal Fluid Penetration and Pharmacokinetic/Pharmacodynamic Parameters of Intravenously Administered Colistin in a Case of Multidrug-Resistant Acinetobacter baumannii Meningitis. Eur J Clin Microbiol Infect Dis 21, 212–214 (2002). https://doi.org/10.1007/s10096-001-0680-2

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  • DOI: https://doi.org/10.1007/s10096-001-0680-2

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