Collection

Nanomaterials for biomedical imaging and targeting

Submission status
Closed
Nanomaterials, particularly nanoparticles, are emerging as versatile tools in biomedical applications. They offer a number of advantages over existing agents, including unique size, tunable optical and magnetic properties, possibility of targeted delivery and specific binding via surface functionalization. Together with recent advances in the synthesis and engineering, various nanoparticles are very promising tools for non-invasive visualization of cellular functions and biological processes in living subjects. Molecular imaging with use of nanoparticles has a potential in accurate diagnosis and prognosis of diseases such as cancer or Alzheimer's disease at early stages. The main focus of this topic collection is placed on the synthesis, properties and diagnostic, or therapeutical applications of various nanoparticles, including quantum dots, fluorescent, magnetic or plasmonic nanoparticles. Demonstration of analytical performance of the nanomaterial in the bioassay or quantification of the analyte in living subjects is essential. Contributions that cover, but are not limited to, the following topics are welcome: • Quantum dots for in-vitro cell and in-vivo animal imaging of tumors • Upconversion nanoparticles for imaging of cancer and neurodegenerative diseases • Nucleic acid, antibody or peptide-based functional nanomaterials for bioimaging • Nanoparticles functionalized with prostate-specific membrane antigen, Her2, EGFR for prostate and breast cancer diagnostics, and Alzheimer's disease • Surface-enhanced Raman scattering plasmonic nanosensors for pH monitoring in single cells and detection of specific genes for diseases • Plasmonic nanosensors for cellular biosensing, diagnostics and high throughput screening • Nanoparticles for the detection of specific target DNA sequences associated with diseases • Nanoparticles as drug vehicles for targeted delivery and therapy

Editors

  • Šárka Nevolová Šárka Nevolová  &

    Šárka Nevolová

    Šárka Nevolová received her Ph.D. degree in Environmental Chemistry in 2012 from the Masaryk University in Brno, Czech Republic. She focuses her research on optical enzyme-based bioanalytical devices for environmental applications and military-defense. Her research interests also include use of fluorescent probes for bioimaging, immobilization and characterization of enzymes and pH indicators. She has been working as assistant professor at Masaryk University and project manager at International Clinical Research Center of St. Anne's University Hospital Brno since 2021 after finishing her maternity leave.

  • Petr Skládal Petr Skládal

    Petr Skládal

    Petr Skládal is an Associated Professor and Head of the Department of Biochemistry, Faculty of Science, Masaryk University (from 1999 and 2019, respectively). He also heads the Nanobiotechnology Laboratory at the Central European Institute of Technology in Brno (since 2011). His research is focused on enzyme and immunochemical biosensors using electrochemical and piezoelectric transducers, affinity kinetics with surface plasmon resonance systems, conjugation of biomolecules with nanomaterials, and applications of atomic force microscopy in life sciences.

Articles (11 in this collection)