Skip to main content

Antibiotic Resistance, Its Health Impacts and Advancements in Their Removal Techniques with a Focus on Biological Treatment

  • Chapter
  • First Online:
Contaminants in Drinking and Wastewater Sources

Abstract

Resistance to antibiotics in microbes is of serious concern to human health. Antibiotic resistance bacteria and genes are naturally present in pristine environment since ages. Animal feedlot wash, farm and agricultural wastewater, municipal wastewater, excessive production and illegal disposal of antibiotic drugs further aid to prevalence and development of antimicrobial resistance in the water environment. Resistance can be transferred to non-resistance strains through horizontal gene transfer and can directly or indirectly impact human health. In this scenario, much advancement in water treatment technologies has emerged to address the issue. However, a great deal of knowledge of different pathogenic microbes, their resistance mechanism and spread in environmental compartments and effect on health is lacking. Therefore, detailed study needs to be conducted to estimate potential risk and water treatment plants and effluent discharge should be designed and monitored meticulously.

Rajneesh Kumar and Payal Mazumder are the joint first authors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Agunbiade FO, Moodley B (2014) Pharmaceuticals as emerging organic contaminants in Umgeni River water system, KwaZulu-Natal, South Africa. Environ Monit Assess 186:7273–7291

    Article  CAS  Google Scholar 

  • Álvarez-Torrellas S, Ribeiro RS, Gomes HT, Ovejero G, García J (2016) Removal of antibiotic compounds by adsorption using glycerol-based carbon materials. Chem Eng J 96:277–288

    Article  Google Scholar 

  • Anderson N, Jones JG, Page-Dumroese D, McCollum D, Baker S, Loeffler D, Chung W (2013) A comparison of producer gas, biochar, and activated carbon from two distributed scale thermochemical conversion systems used to process forest biomass. Energies 6

    Google Scholar 

  • Ashbolt NJ, Amézquita A, Backhaus T, Borriello P, Brandt KK, Collignon P, Coors A, Finley R, Gaze WH, Heberer T, Lawrence JR, Larsson DGJGJ, McEwen SA, Ryan JJ, Schönfeld J, Silley P, Snape JR, Van den Eede C, Topp E (2013) Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance. Environ Health Perspect 121:993–1001

    Article  Google Scholar 

  • Ashfaq M, Khan KN, Rasool S, Mustafa G, Saif-Ur-Rehman M, Nazar MF, Sun Q, Yu CP (2016) Occurrence and ecological risk assessment of fluoroquinolone antibiotics in hospital waste of Lahore. Pakistan Environ Toxicol Pharmacol 42:16–22

    Article  CAS  Google Scholar 

  • Barancheshme F, Munir M (2018) Strategies to combat antibiotic resistance in the wastewater treatment plants. Front Microbiol 8:2603. https://doi.org/10.3389/fmicb.2017.02603

    Article  Google Scholar 

  • Bengtsson-Palme J, Kristiansson E, Larsson DGJJ (2018) Environmental factors influencing the development and spread of antibiotic resistance. FEMS Microbiol Rev 42:68–80. https://doi.org/10.1093/femsre/fux053

    Article  CAS  Google Scholar 

  • Berendonk TU, Manaia CM, Merlin C, Fatta-Kassinos D, Cytryn E, Walsh F, Bürgmann H, Sørum H, Norström M, Pons MN, Kreuzinger N, Huovinen P, Stefani S, Schwartz T, Kisand V, Baquero F, Martinez JL (2015) Tackling antibiotic resistance: the environmental framework. Nat Rev Microbiol 13:310–317. https://doi.org/10.1038/nrmicro3439

    Article  CAS  Google Scholar 

  • Breazeal MR, Novak JT, Vikesland PJ, Pruden A (2013) Effect of wastewater colloids on membrane removal of antibiotic resistance genes. Water Res 47:130–140

    Article  Google Scholar 

  • Calisto V, Ferreira CIA, Oliveira JABP, Otero M, Esteves VI (2015) Adsorptive removal of pharmaceuticals from water by commercial and waste-based carbons. J Environ Manag 152(Suppl. C):83–90

    Google Scholar 

  • Chamosa LS, Álvarez VE, Nardelli M, Quiroga MP, Cassini MH, Centrón D (2017) Lateral antimicrobial resistance genetic transfer is active in the open environment. Sci Rep 7:1–12. https://doi.org/10.1038/s41598-017-00600-2

    Article  CAS  Google Scholar 

  • Chen J, Wei XD, Liu YS, Ying GG, Liu SS, He LY, Su HC, Hu LX, Chen FR, Yang YQ (2016) Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Optimization of wetland substrates and hydraulic loading. Sci Total Environ 565:240–248

    Article  CAS  Google Scholar 

  • Chen L, Chen XL, Zhou CH, Yang HM, Ji SF, Tong DS, Zhong ZK, Yu WH, Chu MQ (2017) Environmental-friendly montmorillonite-biochar composites:facile production and tunable adsorption-release of ammonium and phosphate. J Clean Prod 156:648–659

    Google Scholar 

  • Choi KJ, Kim SG, Kim SH (2008) Removal of antibiotics by coagulation and granular activated carbon filtration. J Hazard Mater 151(1):38–43

    Google Scholar 

  • Clara M, Windhofer G, Weilgony P, Gans O, Denner M, Chovanec A, Zessner M (2012) Identification of relevant micropollutants in Austrian municipal wastewater and their behavior during wastewater treatment. Chemosphere 87:1265–1272

    Article  CAS  Google Scholar 

  • Costanzo SD, Murby J, Bates J (2005) Ecosystem response to antibiotics entering the aquatic environment. Mar Pollut Bull 51(1):218–223

    Article  CAS  Google Scholar 

  • Crespo-Alonso M, Nurchi VM, Biesuz R, Alberti G, Spano N, Pilo MI, Sanna G (2013) Biomass against emerging pollution in wastewater: ability of cork for the removal of ofloxacin from aqueous solutions at different pH. J. Environ. Chem. Eng. 1(4):1199–1204

    Article  CAS  Google Scholar 

  • Das N, Patel AK, Deka G, Das A, Sarma KP, Kumar M (2015) Geochemical controls and future perspective of arsenic mobilization for sustainable groundwater management: a study from Northeast India. Ground Sustainable Dev 1(1–2):92–104

    Article  Google Scholar 

  • Deng W, Li N, Zheng H, Lin H (2016) Occurrence and risk assessment of antibiotics in river water in Hong Kong. Ecotoxicol Environ Saf 125:121–127

    Article  CAS  Google Scholar 

  • Dong B, Kahl A, Cheng L, Vo H, Ruehl S, Zhang T, Snyder S, Saez AE, Quanrud D, Arnold RG (2015) Fate of trace organics in a wastewater effluent dependent stream. Sci Total Environ 518–519:479–490

    Article  Google Scholar 

  • Du J, Geng J, Ren H, Ding L, Xu K, Zhang Y (2015) Variation of antibiotic resistance genes in municipal wastewater treatment plant with A2O-MBR system. Environ Sci Pollut Res 22(3715):3726

    Google Scholar 

  • Durso LM, Miller DN, Wienhold BJ (2012) Distribution and quantification of antibiotic resistant genes and bacteria across agricultural and non-agricultural metagenomes. PLoS ONE 7(11):e48325

    Article  CAS  Google Scholar 

  • Fang G, Liu C, Gao J, Dionysiou DD, Zhou D (2015) Manipulation of persistent free radicals in biochar to activate persulfate for contaminant degradation. Environ Sci Technol 49(9):5645–5653

    Article  CAS  Google Scholar 

  • Félix-Cañedo TE, Durán-Álvarez JC, Jiménez-Cisneros B (2013) The occurrence and distribution of a group of organic micropollutants in Mexico city’s water sources. Sci Total Environ 454–455:109–118

    Article  Google Scholar 

  • Fernandes JP, Almeida CMR, Pereira AC, Ribeiro IL, Reis I, Carvalho P, Basto MCP, Mucha AP (2015) Microbial community dynamics associated with veterinary antibiotics removal in constructed wetlands microcosms. Bioresour Technol 182:26–33

    Article  CAS  Google Scholar 

  • Finley RL, Collignon P, Larsson DGJ, McEwen SA, Li XZ, Gaze WH, Reid-Smith R, Timinouni M, Graham DW, Topp E (2013) The scourge of antibiotic resistance: the important role of the environment. Clin Infect Dis 57:704–710. https://doi.org/10.1093/cid/cit355

    Article  Google Scholar 

  • Fry JC, Day MJ (1990) Plasmid transfer in the epilithon. Bacterial Genet Nat Environ 172–181

    Google Scholar 

  • Galvin S, Boyle F, Hickey P, Vellinga A, Morris D, Cormican M (2010) Enumeration and characterization of antimicrobial-resistant Escherichia coli bacteria in effluent from municipal, hospital, and secondary treatment facility sources. Appl Environ Microbiol 2010:4772–4779

    Article  Google Scholar 

  • Gan IN, Tan HS (2019) A small RNA decreases the sensitivity of Shigella sonnei to norfloxacin. BMC Res Notes 12(1)

    Google Scholar 

  • Gogoi A, Mazumder P, Tyagi VK, Chaminda GGT, An AK, Kumar M (2018) Occurrence and fate of emerging contaminants in water environment: A review. Ground Water Sustainable Deve 6:169–180

    Article  Google Scholar 

  • Gonzalez-Pleiter M, Gonzalo S, Rodea-Palomares I, Leganes F, Rosal R, Boltes K, Fernandez Pinas F (2016) Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Water Res 47(6):2050–2064

    Article  Google Scholar 

  • Gothwal R, Shashidhar T (2015) Antibiotic pollution in the environment: a review. Clean - Soil, Air, Water. https://doi.org/10.1002/clen.201300989

    Article  Google Scholar 

  • Goyne KW, Chorover J, Kubicki JD, Zimmerman AR, Brantley SL (2005) Sorption of the antibiotic ofloxacin to mesoporous and nonporous alumina and silica. J Colloid Interface Sci 283(1):160–170

    Article  CAS  Google Scholar 

  • Guo R, Xie X, Chen J (2015) The degradation of antibiotic amoxicillin in the Fenton-activated sludge combined system. Environ Technol (United Kingdom) 36:844–851. https://doi.org/10.1080/09593330.2014.963696

    Article  CAS  Google Scholar 

  • Guo WQ, Wu YY, Du JS (2016) Advanced oxidation processes for antibiotics removal in aqueous environment. In: 2nd annual international conference on energy, environmental & sustainable ecosystem development (EESED 2016). Atlantis Press

    Google Scholar 

  • Guo XY, Yan Z, Zhang Y, Xu WL, Kong DY, Shan ZJ, Wang N (2018) Behavior of antibiotic resistance genes under extremely high-level antibiotic selection pressures in pharmaceutical wastewater treatment plants. Sci Total Environ 612:119–128

    Article  CAS  Google Scholar 

  • Gupta PK, Pant ND, Bhandari R, Shrestha P (2016) Cholera outbreak caused by drug resistant Vibrio cholerae serogroup O1 biotype ElTor serotype Ogawa in Nepal; a cross-sectional study. Antimicrob Resist Infect Control 5(1). https://doi.org/10.1186/s13756-016-0122-7

  • Halling-Sørensen B, Lützhøft HCH, Andersen HR, Ingerslev F (2000) Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and costaciprofloxacin. J Antimicrob Chemother 46:53–58

    Article  Google Scholar 

  • Heyward S, Yang M, Gaffney J (2019) BioIVT (formerly Ascendance Biotechnology and Hepregen Corporation), Medford, MA

    Google Scholar 

  • Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69(2):334–342

    Article  CAS  Google Scholar 

  • Huang H, Li JR, Wang K, Han T, Tong M, Li L, Xie Y, Yang Q, Liu D, Zhong C (2015a) An in situ self-assembly template strategy for the preparation of hierarchical-pore metal-organic frameworks. Nat Commun 6:8847

    Article  CAS  Google Scholar 

  • Huang X, Liu C, Li K, Su J, Zhu G, Liu L (2015b) Performance of vertical up-flow constructed wetlands on swine wastewater containing tetracyclines and tet genes. Water Res 70:109–117

    Article  CAS  Google Scholar 

  • Ikehata K, Naghashkar NJ, El-Din MG (2006) Degradation of aqueous pharmaceuticals by ozonation and advanced oxidation processes: a review. Ozone Sci Eng 28(6):353–414

    Article  CAS  Google Scholar 

  • Inyang M, Gao B, Zimmerman A, Zhou YM, Cao XD (2015) Sorption and cosorption of lead and sulfapyridine on carbon nanotube-modified biochars. Environ. Sci. Pollut. Control Ser. 22(3):1868–1876

    Article  CAS  Google Scholar 

  • Jiao S, Zheng S, Yin D, Wang L, Chen L (2008) Aqueousphotolysisof tetracycline and toxicity of photolytic products to luminescent bacteria. Chemosphere 73(3):377–382

    Article  CAS  Google Scholar 

  • Jung C, Park J, Lim KH, Park S, Heo J, Her N, Oh J, Yun S, Yoon Y (2013) Adsorption of selected endocrine disrupting compounds and pharmaceuticals on activated biochars. J Hazard Mater 263(Part 2):702–710

    Google Scholar 

  • Kim S, Yun Z, Ha UH, Lee S, Park H, Kwon EE, Cho Y, Choung S, Oh J, Medriano CA, Chandran K (2014) Transfer of antibiotic resistance plasmids in pure and activated sludge cultures in the presence of environmentally representative micro-contaminant concentrations. Sci Total Environ 468–469:813–820

    Article  Google Scholar 

  • Kumar M, Furumai H, Kurisu F, Kasuga I (2010) Evaluating the mobile heavy metal pool in soakaway sediment, road dust and soil through sequential extraction and isotopic exchange. Water Sci Technol 62(4):920–928

    Article  CAS  Google Scholar 

  • Kumar M, Das A, Das N, Goswami R, Singh UK (2016) Co-occurrence perspective of arsenic and fluoride in the groundwater of Diphu, Assam, Northeastern India. Chemosphere 150:227–238

    Article  CAS  Google Scholar 

  • Kummerer K (2009) Antibiotics in the aquatic environment—a review-part I. Chemosphere 75(4):417–434

    Article  Google Scholar 

  • Kummerer K (2010) Pharmaceuticals in the environment. Annu Rev Environ Resour 35:57–75

    Article  Google Scholar 

  • Larsson DGJ, de Pedro C, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751–755

    Article  CAS  Google Scholar 

  • Le TH, Ng C, Tran NH, Chen H, Gin KYH (2018) Removal of antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in municipal wastewater by membrane bioreactor systems. Water Res 145:498–508

    Article  CAS  Google Scholar 

  • Lee J, Farha OK, Roberts J, Scheidt KA, Nguyen ST, Hupp JT (2009) Metal-organic framework materials as catalysts. Chem Soc Rev 38:1450–1459

    Article  CAS  Google Scholar 

  • Li B, Zhang T (2010) Biodegradation and adsorption of antibiotics in the activated sludge process. Environ Sci Technol 44:3468–3473. https://doi.org/10.1021/es903490h

    Article  CAS  Google Scholar 

  • Li B, Qiub Y, Li J, Liang P, Huang X (2019) Removal of antibiotic resistance genes in four full-scale membrane bioreactors. Sci Total Environ 653:112–119

    Article  CAS  Google Scholar 

  • Liu W, Zhang J, Zhang C, Ren L (2011) Sorption of norfloxacin by lotus stalk-based activated carbon and iron-doped activated alumina: mechanisms, isotherms and kinetics. Chem Eng J 171(2):431–438

    Article  CAS  Google Scholar 

  • Luca G, Sacchetti R, Leoni E, Zanetti F (2013) Removal of indicator bacteriophages from municipal wastewater by a full-scale membrane bioreactor and a conventional activated sludge process: implications to water reuse. Bioresour Technol 129:526–531

    Article  Google Scholar 

  • Lucas D, Badia-Fabregat M, Vicent T, Caminal G, Rodríguez-Mozaz S, Balcázar JL, Barceló D (2016) Fungal treatment for the removal of antibiotics and antibiotic resistance genes in veterinary hospital wastewater. Chemosphere 152:301–308

    Google Scholar 

  • Luo Y, Xu L, Rysz M, Wang Y, Zhang H, Alvarez PJJ (2011) Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the haihe River basin. China Environ Sci Technol 45:1827–1833

    Article  CAS  Google Scholar 

  • Luo Y, Guo W, Ngo HH, Nghiem LD, Hai FI, Zhang J, Liang S, Wang XC (2014) A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment. Sci Total Environ 473–474:619–641

    Article  Google Scholar 

  • Ma Q, Xu X, Luo M, Wang J, Yang C, Hu X, Liang B, Wu F, Yang X, Wang J, Liu H, Li W, Zhong Y, Li P, Xie J, Jia L, Wang L, Hao R, Du X, Qiu S, Song H, Sun Y (2017) A waterborne outbreak of Shigella sonnei with resistance to azithromycin and third-generation cephalosporins in China in 2015. Antimicrob Agents Chemother 61:00308–00317. https://doi.org/10.1128/AAC.00308-17

    Article  Google Scholar 

  • Mahfouz N, Caucci S, Achatz E, Semmler T, Guenther S, Berendonk TU, Schroeder M (2018) High genomic diversity of mulit-drug resistant wastewater Escherichia coli. Sci Rep 8(8928):1–12

    CAS  Google Scholar 

  • Mahmood AR, Al-Haideri HH, Hassan FM (2019) Detection of antibiotics in drinking water treatment plants in baghdad city. Iraq Adv Public Heal 2019:1–10

    Article  Google Scholar 

  • Mao F, Liu X, Wu K, Zhou C, Si Y (2018) Biodegradation of sulfonamides by Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4. Biodegradation 29(2):129–140

    Google Scholar 

  • Marti E, Monclús H, Jofre J, Rodriguez-Roda I, Comas J, Balcázar JL (2011) Removal of microbial indicators from municipal wastewater by a membrane bioreactor (MBR). Bioresour Technol 102(8):5004–5009

    Article  CAS  Google Scholar 

  • Martínez JL (2008) Antibiotics and antibiotic resistance genes in natural environments. Science 321:365

    Article  Google Scholar 

  • Matongo S, Birungi G, Moodley B, Ndungu P (2015) Occurrence of selected pharmaceuticals in water and sediment of Umgeni River, KwaZulu-Natal, South Africa. Environ Sci Pollut Res 22:10298–10308

    Article  CAS  Google Scholar 

  • Meng LW, Li XK, Wang ST, Liu LL, Ma KL, Zhang J (2017) The long-term impact of cefalexin on organic substrate degradation and microbial community structure in EGSB system. Chemosphere 184:215–223. https://doi.org/10.1016/j.chemosphere.2017.05.171

    Article  CAS  Google Scholar 

  • Miran W, Jang J, Nawaz M, Shahzad A, Lee DS (2018) Biodegradation of the sulfonamide antibiotic sulfamethoxazole by sulfamethoxazole acclimatized cultures in microbial fuel cells. Sci Total Environ 627:1058–1065

    Google Scholar 

  • Mohammed HH, Abuo-Rahma GE, Abbas SH, Abdelhafez ES (2019) Current trends and future directions of fluoroquinolones. Curr Med Chemistry 26(17):3132–3149

    Google Scholar 

  • Munir M, Wong K, Xagoraraki I (2011) Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan. Water Res 45:681–693

    Article  CAS  Google Scholar 

  • Navalon S, Alvaro M, Garcia H (2008) Reaction of chlorine dioxide with emergent waterpollutants: product study of the reaction of three β-lactam antibiotics with ClO2. Water Res 42(8):1935–1942

    Article  CAS  Google Scholar 

  • Neudorf KD, Huang YN, Ragush CM, Yost CK, Jamieson RC, Hansen LT (2017) Antibiotic resistance genes in municipal wastewater treatment systems and receiving waters in Arctic Canada. Sci Total Environ 598:1085–1094

    Article  CAS  Google Scholar 

  • Nguyen TT, Bui XT, Luu VP, Nguyen PD, Guo W, Ngo HH (2017) Removal of antibiotics in sponge membrane bioreactors treating hospital wastewater: comparison between hollow fiber and flat sheet membrane systems. Bioresour Technol 240:42–49

    Article  CAS  Google Scholar 

  • Novo A, Manaia CM (2010) Factors influencing antibiotic resistance burden inmunicipal wastewater treatment plants. Appl Microbiol Biotechnol 87(3):1157–1166

    Article  CAS  Google Scholar 

  • Ok YS, Kim SC, Kim KR, Lee SS, Moon DH, Lim KJ, Sung JK, Hur SO, Yang JE (2011) Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province Korea. Environ Monit Assess 174:693–701

    Article  CAS  Google Scholar 

  • O’Neill J (2016) Tackling drug-resistant infections globally: final report and recommendations The Review on Antimicrobial Resistance, London, UK

    Google Scholar 

  • Pena A, Paulo M, Silva LJG, Seifrtová M, Lino CM, Solich P (2010) Tetracycline antibiotics in hospital and municipal wastewaters: a pilot study in Portugal. Anal Bioanal Chem 396:2929–2936

    Article  CAS  Google Scholar 

  • Peng B, Chen L, Que C, Yang K, Deng F, Deng X, Shi G, Xu G, Wu M (2016) Adsorption of antibiotics on graphene and biochar in aqueous solutions induced by p-p interactions. Sci Rep 6:31920

    Article  CAS  Google Scholar 

  • Qamar FN, Yousafzai MT, Khalid M, Kazi AM, Lohana H, Karim S, Khan A, Hotwani A, Qureshi S, Kabir F, Aziz F, Memon NM, Domki MH, Hasan R (2018) Outbreak investigation of ceftriaxone-resistant Salmonella enterica serotype Typhi and its risk factors among the general population in Hyderabad, Pakistan: a matched case-control study. Lancet Infect Dis 18:1368–1376. https://doi.org/10.1016/S1473-3099(18)30483-3

    Article  Google Scholar 

  • Richardson SD (2011) Disinfection by-products: formation and occurrence in drinking water. In: Nriagu JO (ed) The encyclopedia of environmental health. Elsevier, Burlington, MA, pp 110–136

    Chapter  Google Scholar 

  • Rodriguez-Mozaz S, Chamorro S, Marti E, Huerta B, Gros M, Sanchez- Melsio A, Borrego CM, Barcelo D, Balcazar JL (2015) Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river. Water Res 69:234–242

    Article  CAS  Google Scholar 

  • Rothrock MJ Jr, Keen PL, Cook KL, Durso LM, Franklin AM, Dungan RS (2016) How should we be determining background and baseline antibiotic resistance levels in agroecosystems research? J Environ Qual 45:420–431

    Article  CAS  Google Scholar 

  • Sanganyado E, Gwenzi W (2019) Antibiotic resistance in drinking water systems: accurrence, removal, and human health risks. Sci Total Environ 669:785–797

    Article  CAS  Google Scholar 

  • Shields RK, Chen L, Cheng S, Chavda KD, Press EG, Snyder A, Pandey R, Doi Y, Kreiswirth BN, Nguyen MH, Clancy CJ (2017) Emergence of ceftazidime-avibactam resistance due to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant klebsiella pneumoniae Infections. Antimicrob Agents Chemother 61(3)

    Google Scholar 

  • Singh A, Patel AK, Deka JP, Das A, Kumar A, Kumar M (2019) Prediction of arsenic vulnerable zones in groundwater environment of rapidly urbanizing setup, Guwahati, India. Geochemistry, 125590. https://doi.org/10.1016/j.chemer.2019.125590

  • Singh A, Patel AK, Kumar M (2020) Mitigating the risk of Arsenic and Fluoride contamination of groundwater through a multi-model framework of statistical assessment and natural remediation techniques. In: Kumar M, Snow D, Honda R (eds) Emerging issues in the water environment during anthropocene: a south east Asian perspective (ISBN 978–93-81891-41-4), Publisher Springer Nature

    Google Scholar 

  • Song HL, Zhang S, Guo J, Yang YL, Zhang LM, Li H, Yang XL, Liu X (2018) Vertical up-flow constructed wetlands exhibited efficient antibiotic removal but induced antibiotic resistance genes in effluent. Chemosphere 203:434–441

    Article  CAS  Google Scholar 

  • Sun P, Li Y, Meng T, Zhang R, Song M, Ren J (2018). Removal of sulfonamide antibiotics and human metabolite by biochar and biochar/H2O2 in synthetic urine. Water Res 147. https://doi.org/10.1007/978-981-15-4599-3_14

  • Sumida K, Rogow DL, Mason JA, McDonald TM, Bloch ED, Herm ZR, Bae TH, Long JR (2012) Carbon dioxide capture in metal-organic frameworks. Chem Rev 112:724–781

    Article  CAS  Google Scholar 

  • Tahrani L, Van Loco J, Mansour H Ben, Reyns T (2016) Occurrence of antibiotics in pharmaceutical industrial wastewater, wastewater treatment plant and sea waters in Tunisia. J Water Health 14:208–213

    Article  Google Scholar 

  • Tong AYC, Peake BM, Braund R (2011a) Disposal practices for unused medications around the world. Environ Int 37:292–298

    Article  Google Scholar 

  • Tong C, Zhuo X, Guo Y (2011b) Occurrence and risk assessment of four typical fluoroquinolone antibiotics in raw and treated sewage and in receiving waters in Hangzhou China. J Agric Food Chem 59:7303–7309

    Article  CAS  Google Scholar 

  • Tong L, Huang S, Wang Y, Liu H, Li M (2014) Occurrence of antibiotics in the aquatic environment of Jianghan Plain, central China. Sci Total Environ 497–498:180–187

    Article  Google Scholar 

  • Tong J, Tang A, Wang H, Liu X, Huang Z, Wang Z, Zhang J, Wei Y, Su Y, Zhang Y (2019) Microbial community evolution and fate of antibiotic resistance genes along six different full scale municipal wastewater treatment processes. Bioresour Technol 272:489–500

    Article  CAS  Google Scholar 

  • Tran NH, Reinhard M, Gin KYH (2018) Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review. Water Res 133:182–207

    Article  CAS  Google Scholar 

  • Turolla A, Cattaneo M, Marazzi F, Mezzanotte V, Antonelli M (2018) Antibiotic resistant bacteria in urban sewage: role of full-scale wastewater treatment plants on environmental spreading. Chemosphere 191:761–769

    Article  CAS  Google Scholar 

  • Vithanage M, Rajapaksha AU, Tang X, Thiele-Bruhn S, Kim KH, Lee SE, Ok YS (2014) Sorption and transport of sulfamethazine in agricultural soils amended with invasive-plant-derived biochar. J Environ Manag 141(Suppl. C):95–103

    Google Scholar 

  • Vymazal J (2011) Constructed wetlands for wastewater treatment: five decades of experience. Environ Sci Technol 45:61–69

    Article  CAS  Google Scholar 

  • Wang W, Wang H, Zhang W, Liang H, Gao D (2017) Occurrence, distribution, and risk assessment of antibiotics in the Songhua River in China. Environ Sci Pollut Res 24:19282–19292

    Article  CAS  Google Scholar 

  • Wang H, Hu C, Shen Y, Shi B, Zhao D, Xing X (2019) Response of microorganisms in biofilm to sulfadiazine and ciprofloxacin in drinking water distribution systems. Chemosphere 218:197–204

    Article  CAS  Google Scholar 

  • Waseem H, Williams MR, Jameel S, Hashsham SA (2018) Antimicrobial Resistance in the Environment. Water Environ Res 90(10):865–884

    Google Scholar 

  • Watkinson AJ, Murby EJ, Kolpin DW, Costanzo SD (2009) The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. Sci Total Environ 407(8):2711–2723

    Article  CAS  Google Scholar 

  • Wei R, Ge F, Chen M, Wang R (2012) Occurrence of ciprofloxacin, enrofloxacin, and florfenicol in animal wastewater and water resources. J Environ Qual 41:1481–1486

    Article  CAS  Google Scholar 

  • World Health Organization (2017) Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2016–2017. Switzerland, Geneva

    Google Scholar 

  • Wu M, Pan B, Zhang D, Xiao D, Li H, Wang C, Ning P (2013) The sorption of organic contaminants on biochars derived from sediments with high organic carbon content. Chemosphere 90(2):782–788

    Article  CAS  Google Scholar 

  • Xie M, Chen W, Xu Z, Zheng S, Zhu D (2014) Adsorption of sulfonamides to demineralized pine wood biochars prepared under different thermochemical conditions. Environ Pollut 186:187–194

    Article  CAS  Google Scholar 

  • Xu Z, Song X, Li Y, Li G, Luo W (2019) Removal of antibiotics by sequencing-batch membrane bioreactor for swine wastewater treatment. Sci Total Environ 684:23–30

    Article  CAS  Google Scholar 

  • Yan M, Xu C, Huang Y, Nie H, Wang JT (2018) Tetracyclines, sulfonamides and quinolones and their corresponding resistance genes in the Three Gorges Reservoir, China. Sci Total Environ 631–632:840–848

    Google Scholar 

  • Yang SF, Lin CF, Wu CJ, Ng KK, Lin AYC, Hong PKA (2012a) Fate of sulfonamide antibiotics in contact with activated sludge-sorption and biodegradation. Water Res 46(4):1301–1308

    Article  CAS  Google Scholar 

  • Yang W, Lu Y, Zheng F, Xue X, Li N, Liu D (2012b) Adsorption behavior and mechanisms of norfloxacinonto porous resins and carbon nanotube. Chem Eng J 179:112–118

    Article  CAS  Google Scholar 

  • Yao H, Lu J, Wu J, Lu Z, Wilson PC, Shen Y (2012) Adsorption of fluoroquinolone antibiotics by wastewater sludge biochar: role of the sludge source. Water Air Soil Pollut 224(1):1370

    Article  Google Scholar 

  • Yasodara Liyanage G, Manage P (2016) Occurrence, fate and ecological risk of antibiotics in hospital effluent water and sediments in Sri Lanka. Int J Agric Environ Res 2:909–935

    Google Scholar 

  • Yu N, Zhao C, Ma B, Li S, She Z, Guo L, Zhang Q, Zhao Y, Jin C, Gao M (2019) Impact of ampicillin on the nitrogen removal, microbial community and enzymatic activity of activated sludge. Bioresour Technol 272:337–345

    Article  CAS  Google Scholar 

  • Zhang R, Zhang G, Tang J, Xu W, Li J, Liu X, Zou Y, Chen X, Li X (2012a) Levels, spatial distribution and sources of selected antibiotics in the East River (Dongjiang), South China. Aquat Ecosyst Heal Manag 15:210–218

    Article  CAS  Google Scholar 

  • Zhang R, Zhang G, Zheng Q, Tang J, Chen Y, Xu W, Zou Y, Chen X (2012b) Occurrence and risks of antibiotics in the Laizhou Bay, China: impacts of river discharge. Ecotoxicol Environ Saf 80:208–215

    Article  CAS  Google Scholar 

  • Zhang W, Huang MH, Qi FF, Sun PZ, Van Ginkel SW (2013) Effect of trace tetracycline concentrations on the structure of a microbial community and the development of tetracycline resistance genes in sequencing batch reactors. Bioresour Technol 150:9–14

    Article  CAS  Google Scholar 

  • Zheng H, Wang Z, Zhao J, Herbert S, Xing B (2013) Sorption of antibiotic sulfamethoxazole varies with biochars produced at different temperatures. Environ. Pollut 181(Suppl. C):60–67

    Google Scholar 

  • Zhai W, Yang F, Mao D, Luo Y (2016) Fate and removal of various antibiotic resistance genes in typical pharmaceutical wastewater treatment systems. Environ Sci Pollut Res 23(12):12030–12038

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Payal Mazumder .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kumar, R., Mazumder, P., Jawed, M. (2021). Antibiotic Resistance, Its Health Impacts and Advancements in Their Removal Techniques with a Focus on Biological Treatment. In: Kumar, M., Snow, D., Honda, R., Mukherjee, S. (eds) Contaminants in Drinking and Wastewater Sources. Springer Transactions in Civil and Environmental Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-4599-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-4599-3_14

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-4598-6

  • Online ISBN: 978-981-15-4599-3

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics