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Gross Pathology of Lesions in the Thymic Region

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Atlas of Thymic Pathology
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Abstract

Gross examination of excised anterior mediastinal masses can often provide important diagnostic information. This chapter presents an approach to that process which is based on generic macroscopic patterns. They include enlargement of the thymus with retention of its overall architecture; prominent cystic change (either unilocular or multilocular); encapsulated solid growth; unencapsulated solid masses with internal necrosis and/or hemorrhage; homogeneously-solid lesions whose cut surfaces resemble “fish-flesh;” unencapsulated masses with a “gritty” cut surface; and proliferations with gross appearances that do not fit into any of the afore-mentioned categories. Macroscopic analysis can initiate a proper consideration of differential diagnostic possibilities in this context.

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References

  1. Detterbeck FC, Parsons AM. Thymic tumors. Ann Thorac Surg. 2004;77:1860–9.

    Article  Google Scholar 

  2. Ganesh Y, Yadala V, Nalini Y, Dal A, Raju AD. Huge mediastinal mass with minimal symptoms: thymolipoma. BMJ Case Rep. 2011;24:2011.

    Google Scholar 

  3. Goldstein AJ, Oliva I, Honarpisheh H, Rubinowitz A. A tour of the thymus: a review of thymic lesions with radiologic and pathologic correlation. Can Assoc Radiol J. 2015;66:5–15.

    Article  Google Scholar 

  4. Guimarães MD, Benveniste MF, Bitencourt AG, Andrade VP, Souza LP, Gross JL, Godoy MC. Thymoma originating in a giant thymolipoma: a rare intrathoracic lesion. Ann Thorac Surg. 2013;96:1083–5.

    Article  Google Scholar 

  5. Jia R, Sulentic P, Xu JM, Grossman AB. Thymic neuroendocrine neoplasms: Biological behavior and therapy. Neuroendocrinology. 2017;105:105–14.

    Article  CAS  Google Scholar 

  6. Kim JH, Goo JM, Lee HJ, Chung MJ, Jung SI, Lim KY, Lee MW, Im JG. Cystic tumors in the anterior mediastinum. Radiologic-pathological correlation. J Comput Assist Tomogr. 2003;27:714–23.

    Article  Google Scholar 

  7. Lack EE. Thymic hyperplasia with massive enlargement: report of two cases with review of diagnostic criteria. J Thorac Cardiovasc Surg. 1981;81:741–6.

    Article  CAS  Google Scholar 

  8. Luh SP, Kuo C, Liu WS, Wu TC, Koo CL, Chen JY. Carcinoid tumor of the thymus: a clinicopathologic report of two cases with a review of the literature. Int Surg. 2005;90:270–4.

    PubMed  Google Scholar 

  9. Miller Q, Moulton MJ, Pratt J. Surgical treatment of thymoma. Curr Surg. 2002;59:101–5.

    Article  Google Scholar 

  10. Quagliano PV. Thymic carcinoma: case reports and review. J Thorac Imaging. 1996;11:66–74.

    Article  CAS  Google Scholar 

  11. Rosado-de-Christenson ML, Galobardes J, Moran CA. Thymoma: radiologic-pathologic correlation. Radiographics. 1992;12:151–68.

    Article  CAS  Google Scholar 

  12. Rosai J. The pathology of thymic neoplasia. Monogr Pathol. 1987;29:161–83.

    Google Scholar 

  13. Sumner TE, Volberg FM, Kiser PE, Shaffner LD. Mediastinal cystic hygroma in children. Pediatr Radiol. 1981;11:160–2.

    Article  CAS  Google Scholar 

  14. Tamura M, Ohta Y, Oda M, Watanabe G. Thymic carcinoid tumor. Jpn J Thorac Cardiovasc Surg. 2003;51:29–31.

    Article  Google Scholar 

  15. Uematsu M, Kondo M. A proposal for treatment of invasive thymoma. Cancer. 1986;58:1979–84.

    Article  CAS  Google Scholar 

  16. Walker AN, Mills SE, Fechner RE. Thymomas and thymic carcinomas. Semin Diagn Pathol. 1990;7:250–65.

    CAS  PubMed  Google Scholar 

  17. Wasserman JK, Purgina B, Sekhon H, Gomes MM, Lai C. The gross appearance of a NUT midline carcinoma. Int J Surg Pathol. 2016;24:85–8.

    Article  CAS  Google Scholar 

  18. Wick MR, Rosai J. Neuroendocrine neoplasms of the thymus. Pathol Res Pract. 1988;183:188–99.

    Article  CAS  Google Scholar 

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Correspondence to Mark R. Wick .

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Wick, M.R., Bishop, J.A. (2020). Gross Pathology of Lesions in the Thymic Region. In: Jain, D., Bishop, J.A., Wick, M.R. (eds) Atlas of Thymic Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-15-3164-4_6

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  • DOI: https://doi.org/10.1007/978-981-15-3164-4_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-3163-7

  • Online ISBN: 978-981-15-3164-4

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