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Mediastinum and Thymus

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Essentials of Anatomic Pathology

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Abstract

This chapter summarizes the nonneoplastic (inflammatory processes as well as congenital and acquired cysts) and neoplastic lesions (thymoma, thymic carcinomas, lymphomas, germ cell tumors, neurogenic tumors, and other soft tissue tumors) involving the mediastinum and thymus. Lymphoproliferative lesions and germ cell tumors resemble their counterparts outside the mediastinum. Thymomas are uncommon tumors which arise from the thymic epithelium. Although their behavior is generally indolent, they are capable of invasive growth and metastasis. The most commonly used system for thymoma classification (WHO) was refined in 2014 by the International Thymic Malignancy Interest Group (ITMIG), which introduced major and minor criteria to accurately classify subtypes.

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Authors and Affiliations

  1. Department of Pathology, Florida Hospital, College of Medicine, University of Central Florida, Orlando, FL, USA

    Chung-Che (Jeff) Chang MD, PhD

  2. Department of Pathology, Florida Hospital, Orlando, FL, USA

    Na’im Fanaian MD

  3. Department of Pathology, MetroHealth Medical Center and Case Western Reserve School of Medicine, Cleveland, OH, USA

    Joseph F. Tomashefski Jr. MD

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  1. Chung-Che (Jeff) Chang MD, PhD
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  2. Na’im Fanaian MD
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  3. Joseph F. Tomashefski Jr. MD
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Correspondence to Joseph F. Tomashefski Jr. MD .

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Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Liang Cheng

  2. Granger Diagnostics, A Division of Granger Genetics, North Chesterfield, Virginia, USA

    David G. Bostwick

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Chang, CC.(., Fanaian, N., Tomashefski, J.F. (2016). Mediastinum and Thymus. In: Cheng, L., Bostwick, D. (eds) Essentials of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-23380-2_26

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