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The Impacts of Associative Memory Cells on Pathology

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Associative Memory Cells: Basic Units of Memory Trace

Abstract

Neurological diseases and psychological disorders with cognition and mood impairment are more or less accompanied by memory deficits, since the capability and efficiency of normal cognitions, emotion, and behaviors are influenced by memory capacity. In psychiatric diseases, fear memory induced by acute severe stress is coupled with anxiety, the accumulated memories to negative outcomes induced by chronic mild stress may lead to anhedonia and low self-esteem in major depression, and weird memory is associated with schizophrenia. Memory deficits are also associated with neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. The etiology and pathogenesis of memory deficits in neurological and psychiatric diseases remain unknown. As memory-relevant cognition and behaviors are based on the number and functional state of associative memory cells, it is hypothesized that these disease-associated memory deficits may be caused by pathological alternation in associative memory cells. Many genes and proteins in neurons are believed to result in these neurological and psychiatric diseases, and certain molecules accumulated in extracellular spaces are thought to deteriorate neuron encoding and synapse transmission. Associative memory cells are neuronal in nature prior to their recruitment for basic memory units; these intracellular and extracellular molecules that impair neurons may influence synapse innervations, synapse transmission efficiency, and spike-encoding capability at these associative memory cells and in turn take them to be abnormal. Pathological alternation in the synapse innervation, structural identity, and functional state of associative memory cells eventually results in memory deficits in these neurological and psychiatric diseases. Although this hypothesis needs to be tested experimentally, pathological alternations in neurons can be cited to associative memory cells. Here, the dysfunction of associative memory cells for memory deficits is discussed.

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  1. University of Chinese Academy of Sciences, Beijing, China

    Jin-Hui Wang

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Wang, JH. (2019). The Impacts of Associative Memory Cells on Pathology. In: Associative Memory Cells: Basic Units of Memory Trace. Springer, Singapore. https://doi.org/10.1007/978-981-13-9501-7_9

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