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Modulation of miRNA in Oxidative Stress-Induced Cardiac Remodeling

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Modulation of Oxidative Stress in Heart Disease

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Abstract

Cardiac remodeling is the pathological ramification of myocardium resulting into various cardiac diseases. Oxidative stress represents a self-perpetuating mechanism by producing excess reactive oxygen species (ROS) and plays a critical role in cardiac remodeling. A redox state that maintains the homeostatic balance in the cell is critical in cardiac remodeling. A misbalance of redox state triggers cellular damage and promoting adverse signaling pathways leading to apoptosis. MicroRNAs (miRNAs) are short, 19–21 nucleotides, endogenous noncoding RNAs modulate gene regulation, elicits a vital role in cardiac remodeling including cardiac hypertrophy, fibrosis, myocardial injury and arrythmia via multiple mechanisms. Recent studies indicated that miRNAs are influencing the generation of ROS and modulate antioxidant defense mechanism by regulating antioxidative enzymes and are termed as “redoximiRs.” Here, I review the current progress and the mechanisms by which “redoximiRs” regulate cardiac remodeling.

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Change history

  • 22 January 2020

    The figure legends of Figs. 3.2 and 3.3 of this chapter were swapped inadvertently and published with errors. The correct presentation is given here.

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Acknowledgments

The work was partly supported by funds from American Heart Association: Grant-in-Aid (17GRNT33670897) to S Gupta. The material is the result of work supported with resources and the use of facilities at the Central Texas Veterans Affairs Health Care System, Temple, Texas; VISN 17 Center of Excellence on Returning War Veterans, Waco, Texas, USA.

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Authors and Affiliations

  1. Central Texas Veterans Health Care System, Temple, TX, USA

    Sudhiranjan Gupta

  2. VISN 17 Center of Excellence on Returning War Veterans, Doris Miller VA Medical Center, Waco, TX, USA

    Sudhiranjan Gupta

  3. Department of Biology, Baylor University, Waco, TX, USA

    Sudhiranjan Gupta

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  1. Sudhiranjan Gupta
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Correspondence to Sudhiranjan Gupta .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Science, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada

    Naranjan S. Dhalla

  3. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Madhu Dikshit

  4. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Nirmal K. Ganguly

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Gupta, S. (2019). Modulation of miRNA in Oxidative Stress-Induced Cardiac Remodeling. In: Chakraborti, S., Dhalla, N., Dikshit, M., Ganguly, N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-8946-7_3

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