Abstract
Owing to the excellent biodegradability and biocompatibility of starch, numerous efforts have been undertaken to prepare stimulus-responsive drug delivery systems (DDSs) from starch and its derivatives during the past few decades. The biological stimuli at the different organ and cellular compartment-specific levels or pathological conditions including pH, enzyme, temperature, and redox potential have been exploited for the development of starch-based stimulus-responsive DDSs. These types of stimulus responsiveness of starch-based DDSs can be achieved by incorporating functional groups to starch, such as disulfide bonds to acquire redox sensitiveness, or by changing physicochemical properties, such as hydrophilicity/hydrophobicity of starch derivatives to acquire temperature sensitiveness. Besides, magnetic-responsive starch-based DDSs have been developed by the incorporation of magnetic particles with starch film coatings or in starch matrix. The individual starch-based, stimulus-responsive DDSs have to some extent been reasonably well validated. Furthermore, two or more response elements have been combined to functionalize starch-based DDSs for smart drug release behavior. In this chapter, the role and application of starch and its derivatives in DDSs endowed with individual, dual, and multi-stimuli responsiveness will be discussed.
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Chen, J., Chen, L., Xie, F., Li, X. (2019). Starch-Based DDSs with Stimulus Responsiveness. In: Drug Delivery Applications of Starch Biopolymer Derivatives. Springer, Singapore. https://doi.org/10.1007/978-981-13-3657-7_4
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