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Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

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Abstract

By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.

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References

  1. A.K. Gupta, M. Gupta, Biomaterials 26, 3995 (2005). doi:10.1016/j.biomaterials.2004.10.012

    Article  PubMed  CAS  Google Scholar 

  2. Z.F. Gan, J.S. Jiang, Prog. Chem. 17, 978 (2005)

    CAS  Google Scholar 

  3. B. Zebli, A.S. Susha, G.B. Sukhorukov, A.L. Rogach, W.J. Parak, Langmuir 21, 4262 (2005). doi:10.1021/la0502286

    Article  PubMed  CAS  Google Scholar 

  4. N. Kohler, C. Sun, J. Wang, M. Zhang, Langmuir 21, 8858 (2005). doi:10.1021/la0503451

    Article  PubMed  CAS  Google Scholar 

  5. L.O. Cinteza, T.Y. Ohulchanskyy, Y. Sahoo, E.J. Bergey, R.K. Pandey, P.N. Prasad, Mol. Pharm. 3, 415 (2006). doi:10.1021/mp060015p

    Article  PubMed  CAS  Google Scholar 

  6. M. Trepel, W. Arap, R. Pasqualini, Curr. Opin. Chem. Biol. 6, 399 (2002). doi:10.1016/S1367-5931(02)00336-8

    Article  PubMed  CAS  Google Scholar 

  7. O.H. Aina, T.C. Sroka, M.L. Chen, K.S. Lam, Biopolymers 66, 184 (2002). doi:10.1002/bip.10257

    Article  PubMed  CAS  Google Scholar 

  8. R. Pasqualini, E. Ruoslahti, Nature 380, 364 (1996). doi:10.1038/380364a0

    Article  PubMed  CAS  ADS  Google Scholar 

  9. V.M. Garsky, P.K. Lumma, D.M. Feng, J. Wai, H.G. Ramjit, M.K. Sardana et al., J. Med. Chem. 44, 4216 (2001). doi:10.1021/jm0101996

    Article  PubMed  CAS  Google Scholar 

  10. S. Achilefu, A. Srinivasan, M.A. Schmidt, H.N. Jimenez, J.E. Bugaj, J.L. Erion, J. Med. Chem. 46, 3403 (2003). doi:10.1021/jm030081k

    Article  PubMed  CAS  Google Scholar 

  11. F.J.-J. Toublan, S. Boppart, K.S. Suslick, J. Am. Chem. Soc. 128, 3472–3473 (2006). doi:10.1021/ja0544455

    Article  PubMed  CAS  Google Scholar 

  12. M.E. Åkerman, W.C.W. Chan, P. Laakkonen, S.N. Bhatia, E. Ruoslahti, Proc. Natl. Acad. Sci. U.S.A. 99, 12617 (2002). doi:10.1073/pnas.152463399

    Article  PubMed  ADS  Google Scholar 

  13. Z.F. Gan, J.S. Jiang, Y. Yang, B. Du, M. Qian, P. Zhang, J. Biomed. Mater. Res. A 84A, 10 (2008). doi:10.1002/jbm.a.31181

    Article  CAS  Google Scholar 

  14. J.S. Jiang, Z.F. Gan, Y. Yang, B. Du, M. Qian, P. Zhang, J. Nanopart. Res. (revised)

  15. D.K. Kweon, D.S. Cha, H.J. Park, S.T. Lim, J. Appl. Polym. Sci. 78, 986 (2000). doi:10.1002/1097-4628(20001031)78:5<986::AID-APP70>3.0.CO;2-T

    Article  CAS  Google Scholar 

  16. J. Zhang, S. Rana, R.S. Srivastava, R.D.K. Misra, Acta Biomater. 4, 40 (2008). doi:10.1016/j.actbio.2007.06.006

    Article  PubMed  CAS  Google Scholar 

  17. R.C. Mundargi, N.B. Shelke, A.P. Rokhade, S.A. Patil, T.M. Aminabhavi, Carbohydr. Polym. 71, 42 (2008). doi:10.1016/j.carbpol.2007.05.013

    Article  CAS  Google Scholar 

  18. R.D. Waldron, J. Phys. Rev. 99, 1727 (1955). doi:10.1103/PhysRev.99.1727

    Article  CAS  ADS  Google Scholar 

  19. S. Rana, A. Gallo, R.S. Srivastava, R.D.K. Misra, Acta Biomater. 3, 233 (2007). doi:10.1016/j.actbio.2006.10.006

    Article  PubMed  CAS  Google Scholar 

  20. G. Smulevich, A. Feis, J. Phys. Chem. 90, 6388 (1986). doi:10.1021/j100281a064

    Article  CAS  Google Scholar 

  21. N. Strekal, A. German, G. Gachko, A. Maskevich, S. Maskevich, J. Mol. Struct. 563–564, 183 (2001). doi:10.1016/S0022-2860(01)00512-9

    Article  Google Scholar 

  22. G.R. Martin, R.K. Jain, Cancer Res. 54, 5670 (1994)

    PubMed  CAS  Google Scholar 

  23. I.F. Tannock, D. Rotin, Cancer Res. 49, 4373 (1989)

    PubMed  CAS  Google Scholar 

  24. K. Engin, D.B. Leeper, J.R. Cater, A.J. Thistlethwaite, L. Tupchong, J.D. McFarlane, Int. J. Hyperther. 11, 211 (1995). doi:10.3109/02656739509022457

    Article  CAS  Google Scholar 

  25. H. Simpkins, L.F. Pearlman, L.M. Thompson, Cancer Res. 44, 613 (1984)

    PubMed  CAS  Google Scholar 

  26. T.K. Jain, M.A. Morales, S.K. Sahoo, D.L. Leslie-Pelecky, V. Labhasetwar, Mol. Pharm. 2, 194 (2005). doi:10.1021/mp0500014

    Article  PubMed  CAS  Google Scholar 

  27. N. Nasongkla, E. Bey, J. Ren, H. Ai, C. Khemtong, J.S. Guthi et al., Nano. Lett. 6, 2427 (2006). doi:10.1021/nl061412u

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

This research project is supported by Shanghai Nanotechnology Promotion Center (0652nm009, 0352nm113).

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Authors and Affiliations

  1. Department of Physics, Center of Functional Nanomaterials and Devices, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, People’s Republic of China

    Yong Yang, Ji-Sen Jiang & Zhi-Feng Gan

  2. School of Life Science, East China Normal University, Shanghai, 200062, People’s Republic of China

    Bing Du, Min Qian & Ping Zhang

Authors
  1. Yong Yang
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  2. Ji-Sen Jiang
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  3. Bing Du
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  4. Zhi-Feng Gan
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  5. Min Qian
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Correspondence to Ji-Sen Jiang.

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Yang, Y., Jiang, JS., Du, B. et al. Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting. J Mater Sci: Mater Med 20, 301–307 (2009). https://doi.org/10.1007/s10856-008-3577-0

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  • DOI: https://doi.org/10.1007/s10856-008-3577-0

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