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Structural and Functional Characterization of Sesbania Mosaic Virus

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A Century of Plant Virology in India

Abstract

The genus Sobemovirus includes isometric, single-stranded positive sense RNA plant viruses that infect monocots and dicots. Sesbania mosaic virus (SeMV) is the only sobemovirus, which has been studied extensively in India. SeMV, which was identified in southern India, is highly stable and multiplies to high concentration causing mosaic symptoms on the leaves of Sesbania grandiflora. SeMV has served as a good model for understanding the molecular mechanism of assembly, replication and movement of sobemoviruses. The structure of the virion and other chimeric VLPs, along with biochemical investigations has resulted in the elucidation of the mechanism of assembly of SeMV. The complete genome sequence, structure and function of non-structural proteins have also been determined. The review presents a summary of all these findings. SeMV being non-toxic and biodegradable and of low immune response, has been shown as a good candidate for biomedical applications.

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Acknowledgements

We thank late Prof. M.V. Nayudu for initiation of the work summarized in this review on SeMV and Prof. N. Appaji Rao for his encouragement. We acknowledge the contributions made by the following students, research associates and project assistants from HSS and MRN laboratories- Subramanya, Gopinath, Bhuvaneshwari, Lokesh, Satheshkumar, Sangita, Saravanan, Sundareshan, Vijay, Prasad, Gowri, Anju, Subashchandrabose, Smita, Gayathri, Soumya, Govind, Ambily, Usha, Amritha, Ashuthosh, Abhinandan, Kalyani, Sushmitha and Kavitha. The financial support from IISc, DST and DBT is gratefully acknowledged. A.B. and G.P.V.V. acknowledge UGC-CSIR and DST-INSPIRE respectively for their fellowships.

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Authors and Affiliations

  1. Department of Biochemistry, Indian Institute of Science, Bengaluru, India

    Arindam Bakshi, G. P. Vishnu Vardhan & H. S. Savithri

  2. Department of Virology, Sri Venkateswara University, Tirupati, India

    M. Hema

  3. Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, India

    M. R. N. Murthy

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  1. Arindam Bakshi
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  2. G. P. Vishnu Vardhan
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  3. M. Hema
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  4. M. R. N. Murthy
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  5. H. S. Savithri
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Correspondence to H. S. Savithri .

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Editors and Affiliations

  1. Advanced Center for Plant Virology, Indian Agricultural Research Institute, New Delhi, India

    Bikash Mandal

  2. Advanced Center for Plant Virology, Indian Agricultural Research Institute, New Delhi, India

    Govind Pratap Rao

  3. Advanced Center for Plant Virology, Indian Agricultural Research Institute, New Delhi, India

    Virendra Kumar Baranwal

  4. Advanced Centre for Plant Virology, Indian Agricultural Research Institute, New Delhi, India

    Rakesh Kumar Jain

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Bakshi, A., Vishnu Vardhan, G.P., Hema, M., Murthy, M.R.N., Savithri, H.S. (2017). Structural and Functional Characterization of Sesbania Mosaic Virus. In: Mandal, B., Rao, G., Baranwal, V., Jain, R. (eds) A Century of Plant Virology in India. Springer, Singapore. https://doi.org/10.1007/978-981-10-5672-7_18

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