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Inherited Thyroid Cancer

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Evidence-Based Endocrine Surgery

Abstract

Thyroid cancer is common and has a steadily rising incidence [1]. Papillary thyroid cancer (PTC) is the most common histologic subtype, accounting for more than 90% of all thyroid cancers. Over 90% of thyroid cancers are sporadic, with less than 10% being familial [2]. Familial thyroid cancers can be divided into familial non-medullary thyroid cancers (FNMTC), or familial medullary thyroid cancers (FMTC) according to their cell of origin. Among FNMTC, about 5% are associated with defined syndromes and occur with a preponderance of non-thyroidal tumours [3] (see Diagram 14.1). The majority however are non-syndromic FNMTC. FMTC, on the other hand, is most commonly associated with multiple endocrine neoplasia (MEN). The presence of certain histological subtypes should also prompt consideration of familial thyroid cancer.

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Author information

Authors and Affiliations

  1. Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

    Joycelyn Lee & Joanne Ngeow

  2. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

    Joanne Ngeow

Authors
  1. Joycelyn Lee
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  2. Joanne Ngeow
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Correspondence to Joanne Ngeow .

Editor information

Editors and Affiliations

  1. Division of Endocrine Surgery, National University Hospital, Singapore, Singapore

    Rajeev Parameswaran

  2. Department of Endocrine Surgery, SGPGI Hospital, Lucknow, India

    Amit Agarwal

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Lee, J., Ngeow, J. (2018). Inherited Thyroid Cancer. In: Parameswaran, R., Agarwal, A. (eds) Evidence-Based Endocrine Surgery. Springer, Singapore. https://doi.org/10.1007/978-981-10-1124-5_14

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  • DOI: https://doi.org/10.1007/978-981-10-1124-5_14

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1123-8

  • Online ISBN: 978-981-10-1124-5

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