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Cytokine-enhanced, Helicobacter pylori-induced, epithelial cell apoptosis

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Helicobacter pylori

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Abstract

It has been well established that the epithelium of the digestive tract turns over every 4–6 days. Previously, it was believed that the proliferative zone provided cells for this renewal and, in turn, these progenitors differentiated and migrated up the villus or gastric gland before being extruded into the lumen. With the development of an assay to measure DNA damage by histochemical techniques, investigators have shown that apoptosis is present in the epithelium of the healthy digestive tract1,2. This suggests that the process of cell loss is regulated and, by extension, a disruption in either the proliferation or removal of epithelial cells could lead to aberrations in epithelial cell function.

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Authors
  1. P. B. Ernst
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  2. V. E. Reyes
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  3. X. -J. Fan
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  4. S. E. Crowe
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1998 Springer Science+Business Media Dordrecht

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Ernst, P.B., Reyes, V.E., Fan, X.J., Crowe, S.E. (1998). Cytokine-enhanced, Helicobacter pylori-induced, epithelial cell apoptosis. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4882-5_15

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  • DOI: https://doi.org/10.1007/978-94-011-4882-5_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6046-2

  • Online ISBN: 978-94-011-4882-5

  • eBook Packages: Springer Book Archive

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