Abstract
It has long been known that the fate of transplanted foreign cells, tissues and organs depends on genetic factors. Basic experiments concerning this problem were performed in laboratory animals, particularly in mice. The genetic basis of tissue incompatibility (histoincompatibility) was demonstrated in inbred animal strains. These are homogeneous animal lines, generated by repeated crossing of brothers and sisters or parents and their progeny over many generations. When the transfer of tissue is performed between individuals of various inbred strains, the graft is generally rejected. Similarly, rejection occurs after tissue transplantation between individuals of normal non-inbred (outbred) populations, e.g. in the human population. On the other hand, grafts transferred between individuals of the inbred line or between monozygotic twins in man, survive permanently. It has been shown that particular antigens are responsible for tissue compatibility (histocompatibility) or incompatibility (histoincompatibility) and determine rejection or survival of the graft. These antigens are products of histocompatibility genes and are therefore called histocompatibility antigens.
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References
Berget, S. M., Moore, C. and Sharp, P. A. (1977) Spliced segments at the 5’-terminus of adenovirus 2 late mRNA. Proc. Nat. Acad. Sci. USA ,74, 3171–75.
Billingham, R. E., Brent, L. and Medawar, P. B. (1954) Quantitative studies on tissue transplantation immunity II. The origin, strength and duration of actively and adoptively acquired immunity. Proc. Roy. Soc. ,B 143, 58–70.
Bodmer, J. G., Marsh, S. G. E. and Albert, E. (1990) Nomenclature for factors of the HLA system, 1989. Immunol. Today ,11, 3–10.
Breathnach, R., Benoist, C., O’Hare, K., Gannon, F. and Chambon, P. (1978) Ovalbumin gene: Evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc. Nat. Acad. Sci. USA ,75, 4853–57.
Breathnach, R., Mandell, J. L. and Chambon, P. (1977) Ovalbumin gene is split in chicken DNA. Nature ,270, 314–19.
Buc, M. (1989) HLA complex in biology and medicine. Bratislava, Veda, 188 pp. (in Slovak).
Buc, M. and Ferenčík M. (1993) Immunogenetics. Bratislava, Alfa, in press. (in Slovak).
Dausset, J. (1958) Isoleuco-anticorps. Acta Haematol. (Basel), 20, 156–61.
Dausset, J. and Pla, M. (1985) HLA complexe majeur d’histocompatibilité de l’homme. Paris, Flamarion Médicine-Science, 414 pp.
Gilbert, W. (1978) Why genes in pieces? Nature ,272, 581–3.
Hána, I., Ivašková, E. and Dostál, C. (1982) The main histocompatibility system of man (HLA) and diseases. Prague, Avicenum, 224 pp. (in Czech).
Hašková, V. and Buc, M. (1985) Advanced notions about the major histocompatibility complex. In: Ferencík, M. and Štefanovič, J. (eds.), Immunology 1985. Bratislava, Immunol. Sect. Czechoslov. Biol. Soc., pp. 191 -99.
Mayr, W. R. (1990) HLA 1990. Blut ,61, 207–12.
Payne, R. and Rolfs, M. R. (1958) Foeto-maternal incompatibility. J. Clin. Invest. ,37, 1756–61.
Snell, G. D. (1948) Methods for the study of histocompatibility genes. J. Genetics ,49, 87–108.
Snell, G. D. (1958) Histocompatibility genes of the mouse. II. Production and analogs of isogenic resistant lines. J. Nat. Cancer Inst. ,21, 843–55.
Snell, G. D. (1976) Histogenetic methods. In: Snell, G. D., Dausset, J. and Nathenson, S. (eds.), Histocompatibility. New York, Acad. Press, pp. 11–21.
Steinmetz, M. and Hood, L. (1983) Genes of the major histocompatibility complex in mouse and man. Science ,222, 727–33.
Steinmetz, M., Winoto, A., Hinard K. and Hood, L. (1982) Clusters of genes encoding mouse transplantation antigens. Cell ,28, 489–98.
Tonegawa, S. (1983) Somatic generation of antibody diversity. Nature ,302, 575–81.
Tonegawa, S., Maxam, S. M., Tizard, R., Bernard, O. and Gilbert, W. (1978) Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. Proc. Nat. Acad. Sci. USA ,75, 1485–92.
Van Rood, J. J., Eernise, J. G. and van Leeuwen, A. (1958) Leucocyte antibodies in sera of pregnant women. Nature ,181, 1735–6.
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Ferenčík, M. (1993). The major histocompatibility complex. In: Handbook of Immunochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1552-0_5
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DOI: https://doi.org/10.1007/978-94-011-1552-0_5
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