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Brain Metastases: Treatment with Stereotactic Iodine-125 Brachytherapy

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Tumors of the Central Nervous System, Volume 11

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 11))

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Abstract

The treatment modalities for brain metastases include, in general, stereotactic radiosurgery (SRS) and/or micro-neurosurgical resection combined with external beam radiation therapy (EBRT) as well as whole brain radiation therapy (WBRT) for multiple cerebral tumors. Presently, stereotactic brachytherapy (SBT) is successfully used for the treatment of well circumscribed (low grade) glial tumors, but can also be applied for the treatment of brain metastases. Especially in cases where histological confirmation is requested SBT can be combined with stereotactic biopsy within one minimal invasive and safe surgical procedure. Due to the favorable radiobiology of low dose rate irradiation and a steep dose fall-off from the irradiation center within the tumor towards the periphery SBT represents a highly localized treatment option for not restricting later EBRT/WBRT, not increasing the risk of adverse irradiation effects when applied in case of local tumor recurrence after previous SRS/EBRT treatment, and for tumors >3 cm in diameter. It also has been demonstrated that the overall survival and local control rates are comparable to those after SRS treatment. Thus, SBT is a safe, effective, and minimal invasive local treatment option for selected patients with a single brain metastasis.

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Authors and Affiliations

  1. Department of Stereotaxy and Functional Neurosurgery, University Hospital of Cologne, Kerpener Strate 62, Main Clinic Bldg, 11th Floor, 50937, Cologne, Germany

    Maximilian I. Ruge, Philipp Kickingereder & Harald Treuer

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  1. Maximilian I. Ruge
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  2. Philipp Kickingereder
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  3. Harald Treuer
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Correspondence to Maximilian I. Ruge .

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Editors and Affiliations

  1. Kean University, Room 213, Library building, Union, New Jersey, USA

    M.A. Hayat

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Ruge, M.I., Kickingereder, P., Treuer, H. (2014). Brain Metastases: Treatment with Stereotactic Iodine-125 Brachytherapy. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 11. Tumors of the Central Nervous System, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7037-9_16

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  • DOI: https://doi.org/10.1007/978-94-007-7037-9_16

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