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MicroRNA in the Pathophysiology of Glioblastoma

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Tumors of the Central Nervous System, Volume 11

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 11))

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Abstract

Glioblastoma Multiforme (GBM) is the most common and aggressive adult intracranial malignancy; with a ~11-month medial survival rate. Radio- and chemo-resistance is a common feature of GBM. The experimental evidence indicates that the currently used anti-neoplastic treatment for GBM can be counteracted by the activation of particular cellular signalling pathways such as p53, PTEN. These pathways can be partly regulated by microRNA (miRNA) through both positive and negative regulatory functions. MiRNA are 18–22 nt small RNA molecules, which bind the 3′ untranslated region (UTR) of specifically targeted mRNA to mediate translational repression. This chapter focuses on the role of specific miRNA molecules on GBM cell signalling and the overall effect on cellular proliferation, viability and treatment resistance.

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Authors and Affiliations

  1. UMDNJ-New Jersey Medical School, MSB, Room E-579, 185 South Orange Avenue, Newark, NJ, 07103, USA

    Jessian Munoz, Steven J. Greco & Pranela Rameshwar

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  1. Jessian Munoz
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  2. Steven J. Greco
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  3. Pranela Rameshwar
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Correspondence to Pranela Rameshwar .

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Editors and Affiliations

  1. Kean University, Room 213, Library building, Union, New Jersey, USA

    M.A. Hayat

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© 2014 Springer Science+Business Media Dordrecht

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Munoz, J., Greco, S.J., Rameshwar, P. (2014). MicroRNA in the Pathophysiology of Glioblastoma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 11. Tumors of the Central Nervous System, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7037-9_10

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  • DOI: https://doi.org/10.1007/978-94-007-7037-9_10

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7036-2

  • Online ISBN: 978-94-007-7037-9

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