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MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas

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Abstract

Gliomas are the most common type of malignant primary brain tumor. Despite advances in surgery, radiation therapy, and chemotherapy, the prognosis of patients with gliomas has not significantly improved. MicroRNAs (miRNAs), a class of non-coding RNAs, 21–25 nucleotides long, negatively regulate the expression of target genes by interacting with specific sites in mRNAs, and play a critical role in the development of gliomas. The EGFR/PTEN/AKT pathway is a promising target for anti-glioma therapy. Recent studies have showed that regulation of the EGFR/PTEN/AKT pathway by miRNAs plays a major role in glioma progression, indicating a novel way to investigate the tumorigenesis, diagnosis, and therapy of gliomas. Here, we focus on recent findings of miRNAs with respect to the EGFR/PTEN/AKT pathway in gliomas.

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Acknowledgments

This work was supported by the China Natural Science Foundation (30872657, 30971136, and 81072078), Natural Science Foundation of Jiangsu Province (2008475 and 2010580), Scientific Program of Ministry of Health (W2011BX009), Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU, and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300, Guangzhou Road, 210029, Nanjing, People’s Republic of China

    Yingyi Wang, Xiefeng Wang, Junxia Zhang, Hui Luo, Ning Liu & Yongping You

  2. Department of Neurosurgery, Tianjin Medical University General Hospital, and Laboratory of Neuro-Oncology, Tianjin Neurological Institute, 300052, Tianjin, People’s Republic of China

    Junxia Zhang, Chunsheng Kang & Peiyu Pu

  3. Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, 224006, Nantong, People’s Republic of China

    Guan Sun

  4. Department of Neurosurgery, Tiantan Hospital, Capital Medical University, 100050, Beijing, People’s Republic of China

    Tao Jiang

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  1. Yingyi Wang
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Correspondence to Yongping You.

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Yingyi Wang, Xiefeng Wang, and Junxia Zhang contributed equally to this work.

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Wang, Y., Wang, X., Zhang, J. et al. MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas. J Neurooncol 106, 217–224 (2012). https://doi.org/10.1007/s11060-011-0679-1

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