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Regulation of Post-Golgi Traffic of G Protein-Coupled Receptors

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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Part of the book series: Subcellular Biochemistry ((SCBI,volume 63))

Abstract

Anterograde trafficking of newly synthesized G protein-coupled ­receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.

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Acknowledgements

This work was supported by National Institutes of Health Grant R01GM076167 (to G Wu).

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Georgia Health Sciences University, 1459 Laney Walker Blvd, Augusta, GA, 30912, USA

    Guangyu Wu

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  1. Guangyu Wu
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Correspondence to Guangyu Wu .

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Editors and Affiliations

  1. Faculty of Medicine, Pharmacology, Dalhousie University, College Street 5968, Halifax, B3H 4R2, Nova Scotia, Canada

    Denis J. Dupré

  2. , Pharmacology and Therapeutics, McGill University, Promenade Sir William Osler 3655, Montreal, H3G 1Y6, Québec, Canada

    Terence E. Hébert

  3. Institut Cochin, Rue Méchain 22, Paris, 75014, France

    Ralf Jockers

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Wu, G. (2012). Regulation of Post-Golgi Traffic of G Protein-Coupled Receptors. In: Dupré, D., Hébert, T., Jockers, R. (eds) GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity. Subcellular Biochemistry, vol 63. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4765-4_5

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