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Thyroid Hormone Receptors

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Nuclear Receptors

Part of the book series: Proteins and Cell Regulation ((PROR,volume 8))

Abstract

Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes. Thyroid hormone receptors were among the first nuclear receptors to be identified and act as ligand-regulated transcription factors. These receptors are particularly versatile since they also have the potential to mediate ligand-independent transcriptional control. Genetic analyses have revealed both specific and overlapping roles for each receptor, revealing how a small receptor family can mediate an extended range of biological functions.

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Acknowledgements

This work was supported in part by the intramural research program at NIDDK at the National Institutes of Health.

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  1. Department of Cell and Molecular Biology, Karolinska Institute, S-171 77, Stockholm, Sweden

    BjÖRn VennstrÖM

  2. NIDDK, Clinical Endocrinology Branch, National Institutes of Health, Bethesda, MD, 20892-1772, USA

    Hong Liu & Douglas Forrest

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  1. School of Biosciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom

    Chris M. Bunce

  2. Dept. Pharmacology & Therapeutics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, 14263, U.S.A.

    Moray J. Campbell

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VennstrÖM, B., Liu, H., Forrest, D. (2010). Thyroid Hormone Receptors. In: Bunce, C., Campbell, M. (eds) Nuclear Receptors. Proteins and Cell Regulation, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3303-1_7

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