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Diepe hersenstimulatie bij therapieresistente epilepsie

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Samenvatting

Epilepsie is een veelvoorkomende neurologische aandoening die met medicatie veelal goed te behandelen is. Wanneer epilepsie echter niet goed op medicatie reageert (bij ongeveer een derde van de patiënten) worden andere behandelmethoden overwogen. In specifieke gevallen kan dan diepe hersenstimulatie ('deep brain stimulation', DBS) van de voorste thalamuskern worden overwogen. Dit leverde in een RCT bij 110 patiënten een aanvalsreductie van gemiddeld meer dan 50 % op, met een gunstige uitkomst (>50 % aanvalsreductie) bij 68 % van de patiënten. Bijwerkingen zijn vooral stemmingsstoornissen, geheugenstoornissen en slaapproblemen. Veel is echter nog onbekend over de optimalisatie van de respons op DBS bij therapieresistente epilepsie.

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Author information

Authors and Affiliations

  1. Afdeling Neurologie, Maastricht UMC+, Maastricht, The Netherlands

    Rob Rouhl

  2. Epilepsiecentrum Kempenhaeghe, Heeze, The Netherlands

    Louis Wagner

  3. Afdeling Neurologie, Universitair Ziekenhuis Gent, Gent, Belgium

    Kristl Vonck

Authors
  1. Rob Rouhl
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  2. Louis Wagner
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  3. Kristl Vonck
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Rouhl, R., Wagner, L., Vonck, K. (2016). Diepe hersenstimulatie bij therapieresistente epilepsie. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_15

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_15

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

  • eBook Packages: Dutch language eBook collection

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