Abstract
Since the description of the first neuroendocrine neoplasm (NEN), published by Oberdorfer at the beginning of the last century [1], the epidemiology of gastroenteropancreatic-NENs (GEP-NENs) has significantly changed, especially over the last decades. In the largest and most recent series of NENs, including those of the GEP type as well as thoracic and unknown primary NENs, a dramatic increase in their age-adjusted incidence in the USA between 1973 and 2004 was reported, from 1.1 to 5.2 per 100,000 inhabitants per year [2]. Many factors are likely to have contributed to this increase, including the improved classification of NENs and the widespread use of endoscopy for cancer screening and of other sensitive imaging procedures such as endoscopy ultrasound (EUS) and computed tomography CT [3].
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Davì, M.V., Toaiari, M., Francia, G. (2013). Epidemiology and Clinical Presentation. In: Pederzoli, P., Bassi, C. (eds) Uncommon Pancreatic Neoplasms. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-2673-5_7
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DOI: https://doi.org/10.1007/978-88-470-2673-5_7
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