Abstract
Membrane lipid transport within and across the membrane is mediated by lipid transport machineries known as flippase, floppase, and scramblase. Flippase translocates lipids from the exocytoplasmic to the cytoplasmic leaflet of cellular membranes, floppase mediates the translocation of lipids in the opposite direction, and scramblase facilitates bidirectional translocation of lipids. These specialized lipid transport machineries are now demonstrated to have crucial roles in a variety of biological processes, including lipid metabolism, immune response, apoptosis, and neural function, in many mammalian species. The Drosophila melanogaster genome contains orthologues to about 70 % of all human disease-associated genes, and thus both traditional genetic approaches and more recent genome-wide screening techniques in Drosophila have been powerful tools for the study of lipid-related processes. There are, however, many open questions about the structure and function of lipids and their transport machineries in Drosophila. In this review, we summarize the functions of flippase, floppase, and scramblase from several species, and discuss the roles of these lipid transporters in D. melanogaster.
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Nagao, K., Juni, N., Umeda, M. (2015). Membrane Lipid Transporters in Drosophila melanogaster . In: Yokomizo, T., Murakami, M. (eds) Bioactive Lipid Mediators. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55669-5_12
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DOI: https://doi.org/10.1007/978-4-431-55669-5_12
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