Skip to main content

Die Hautalterung: Intrinsische und extrinsische Faktoren

  • Chapter
Dermatokosmetik
  • 3345 Accesses

Auszug

Die durchschnittliche Lebenserwartung ist in den letzten Jahrhunderten durch verbesserte Lebensumstände und medizinische Versorgung stetig angestiegen (Abb. 2.1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 19.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adhoute H, de Rigal J, Marchand JP, Privat Y, Léveque LJ (1992) Influence of age and sun exposure on the biophysical properties of the human skin: an in vivo study. Photodermatol Photoimmunol Photomed 9:99–103

    PubMed  CAS  Google Scholar 

  2. Applegate LA, Noel A, Vile G, Frenk E, Tyrrell RM (1995) Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: implications for protection against oxidative stress. Photochem Photobiol 61:285–291

    Article  PubMed  CAS  Google Scholar 

  3. Baulieu EE, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, Faucounau V, Girard L, Hervy MP, Latour F, Leaud MC, Mokrane A, Pitti-Ferrandi H, Trivalle C, de Lacharriere O, Nouveau S, Rakoto-Arison B, Souberbielle JC, Raison J, Le Bouc Y, Raynaud A, Girerd X, Forette F (2000) Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci USA 11;97(8):4279–4284

    Article  CAS  Google Scholar 

  4. Benedetto AV (1998) The environment and skin aging. Clin Dermatol 16:129–139

    Article  PubMed  CAS  Google Scholar 

  5. Bentley JP, Brenner RM, Linstedt AD, West NB, Carlisle KS, Rokosova BC, MacDonald N (1986) Increased hyaluronate and collagen biosynthesis and fibroblast estrogen receptors in macaque sex skin. J Invest Dermatol 87:668–673

    Article  PubMed  CAS  Google Scholar 

  6. Bernerd F, Asselineau D (1998) UVA exposure of human skin reconstructed in vitro induces apoptosis of dermal fibroblasts: subsequent connective tissue repair and implications in photo-aging. Cell Death Differ 5:792–802

    Article  PubMed  CAS  Google Scholar 

  7. Bernstein EF, Underhill CB, Hahn PJ (1996) Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol 135:255–262

    Article  PubMed  CAS  Google Scholar 

  8. Biesalski HK, Berneburg M, Grune T, Kerscher M, Krutmann J, Raab W, Reimann J, Reuther T, Robert L, Schwarz T (2003) Hohenheimer Consensus Talk: Oxidative and premature skin ageing. Exp Dermatol 12(Suppl 3):3–15

    Article  PubMed  CAS  Google Scholar 

  9. Böni R, Burg G (2000) Altershaut: physiologische. Grundlagen, prophylaktische Maßnahmen und Therapieansätze. Schweiz Med Wochenschr 130:1272–1278

    PubMed  Google Scholar 

  10. Braun-Falco O, Plewig G, Wolff HH (Hrsg) (1995) Dermatologie und Venerologie (4. Aufl). Springer, Berlin Heidelberg

    Google Scholar 

  11. Brenneisen P, Wenk J, Klotz LO, Wlaschek M, Briviba K, Krieg T, Sies H, Scharffetter-Kochanek K (1998) Central role of ferrous/ferric iron in the ultraviolet B irradiation-mediated signaling pathway leading to increased interstitial collagenase (Matrix-degrading Metalloprotease (MMP)-1) and Stromelysin-1 (MMP-3) mRNA levels in cultured human dermal fibroblasts. J Biol Chem 273:5279–5287

    Article  PubMed  CAS  Google Scholar 

  12. Brincat MP (2000) Hormone replacement therapy and the skin. Maturitas 35:107–117

    Article  PubMed  CAS  Google Scholar 

  13. Brincat MP, Moniz CF, Studd JW, Darby AJ, Magos A, Cooper D (1983) Sex hormones and skin collagen content in postmenopausal women. Br Med J (Clin Res Ed) 287:1337–1338

    Article  CAS  Google Scholar 

  14. Brincat MP, Versi E, O’Dowd T, Moniz CF, Magos A, Kabalan S, Studd JW (1987) Skin collagen changes in post-menopausal women receiving oestradiol gel. Maturitas 9:1–5

    Article  PubMed  CAS  Google Scholar 

  15. Callens A, Vaillant L, Lecomte P, Berson M, Gall Y, Lorette G (1996) Does hormonal skin aging exist? A study of the influence of different hormone therapy regimens on the skin of postmenopausal women using non-invasive measurement techniques. Dermatology 193: 289–294

    Article  PubMed  CAS  Google Scholar 

  16. Castelo-Branco C, Duran M, Gonzalez-Merlo J (1992) Skin collagen changes related to age and hormone replacement therapy. Maturitas 15: 113–119

    Article  PubMed  CAS  Google Scholar 

  17. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, Cho KH, Kim KH, Park KC, Eun HC (2001) Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 117:1218–1224

    Article  PubMed  CAS  Google Scholar 

  18. Cooper KD, Oberhelman L, Hamilton TA, Baadsgaard O, Terhune M, Le Vee G, Anderson T, Koren H (1992) UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci USA 89:8497–8501

    Article  PubMed  CAS  Google Scholar 

  19. Crawford HC, Matrisian LM (1994–95) Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression. Invasion Metastasis 14:234–245

    PubMed  CAS  Google Scholar 

  20. Cross CE, van der Vliet A, Louie S, Thiele JJ, Halliwell B (1998) Oxidative stress and antioxidants at biosurfaces: plants, skin, and respiratory tract surfaces. Envir Health Perspect 106(Suppl 5):1241–1251

    Article  CAS  Google Scholar 

  21. D’Armiento J, Di Colandrea T, Dalal SS, Okada Y, Huang MT, Conney AH, Chada K (1995) Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis. Mol Cell Biol 15:5732–5729

    PubMed  Google Scholar 

  22. Diffey BL (1992) Human exposure to ultraviolet radiation. In: Marks R, Plewig G (eds) The environmental threat to the skin. Martin Dunitz, London, pp 3–9

    Google Scholar 

  23. Fisher GJ, Wang TQ, Datta SC, Varani J, Kang S, Voorhees JJ (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337;14:1419–1428

    Article  PubMed  CAS  Google Scholar 

  24. Fisher GJ, Voorhees JJ (1998) Molecular mechanisms of photo-aging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Invest Dermatol Symp Proc 3:61–68

    CAS  Google Scholar 

  25. Fitzpatrick TB (1988) The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 124:869–871

    Article  PubMed  CAS  Google Scholar 

  26. Francès C (1998) Smoker’s wrinkles: epidemiological and pathogenic considerations. Clin Dermatol 16:565–570

    Article  PubMed  Google Scholar 

  27. Gilchrest BA (1989) Skin aging and photoaging: An overview. J Am Acad Dermatol 21: 610–613

    Article  PubMed  CAS  Google Scholar 

  28. Gilchrest BA (1996) A review of skin ageing and its medical therapy. Br J Dermatol 135:867–875

    Article  PubMed  CAS  Google Scholar 

  29. Glogau RG (1997) Physiological and structural changes associated with aging skin. Dermatol Clin 15:555–559

    Article  PubMed  CAS  Google Scholar 

  30. Grosman N, Hvidberg E, Schou J (1971) The effect of oestrogenic treatment on the acid mucopolysaccharide pattern in skin of mice. Acta Pharmacol Toxicol (Copenh) 30:458–464

    CAS  Google Scholar 

  31. Gruss C, Reed JA, Altmeyer P, Mc Nutt NS, Kerscher (1997) Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts. Lancet 350:1295–1296

    Article  PubMed  CAS  Google Scholar 

  32. Gruss C, Reed J, Behrens S, Reuther T, Mc Nutt S, Kerscher M, Altmeyer P (1998) UVA-1 phototherapy improves morphea (localised scleroderma) by induction of interstitial collagenase (MMP-1). J Invest Dermatol 110:594

    Google Scholar 

  33. Hall G, Phillips T (2005) Estrogen and skin: the effects of estrogen, menopause and hormone replacement therapy on the skin. J Am Acad Dermatol 53:555–568.

    Article  PubMed  Google Scholar 

  34. Hawk JL, Black AK, Jaenicke KF, Barr RM, Soter NA, Mallett AI, Gilchrest BA, Hensby CN, Parrish JA, Greaves MW (1983) Increased concentrations of arachidonic acid, prostaglandins E2, D2, and 6-oxo-F1 alpha, and histamine in human skin following UVA irradiation. J Invest Dermatol 80:496–499

    Article  PubMed  CAS  Google Scholar 

  35. Henry F, Pierard-Franchimont C, Cauwenbergh G, Pierard GE (1997) Age-related changes in facial skin contours and rheology. J Am Geriatr Soc 45:220–222

    PubMed  CAS  Google Scholar 

  36. Kaminer MS (1995) Phototdamage: magnitude of the problem. In: Gilchrest BA (ed) Photodamage. Blackwell Science, Cambridge, Mass, pp 1–11

    Google Scholar 

  37. Khorranmizadeh MR, Tredget EE, Telasky C, Shen Q, Ghahary A (1999) Aging differentially modulates the expression of collagen and collagenase in dermal fibroblasts. Mol Cell Biochem 194:99108

    Google Scholar 

  38. Kligmann LH (1982) Intensification of ultraviolet-induced dermal damage by infrared radiation. Arch Dermatol Res 272:229–238

    Article  Google Scholar 

  39. Kligman LH (1984) Reflections on heat. Br J Dermatol 110:369–375

    Article  PubMed  CAS  Google Scholar 

  40. Kligman LH (1989) The ultraviolet-irradiated hairless mouse: A model for photo-aging. J Am Acad Dermatol 3:623–631

    Article  Google Scholar 

  41. Kligman AM, Lavker RM (1988) Cuteneous aging: the differences between intrinsic aging and photo-aging. J Cutan Aging Cosmet Dermatol 1:5–12

    Google Scholar 

  42. Kolias N, Stamatas G (2002) Skin aging and photo-aging effects can be quantified in vivo by fluorescence excitation spectroscopy. Photodermatol Photoimmunol Photomed 18:105

    Google Scholar 

  43. Lahmann C, Bergemann J, Harrison G (2001) Young AR. Matrix metalloproteinase-1 and skin ageing in smokers. Lancet 357:935–936

    Article  PubMed  CAS  Google Scholar 

  44. Lahmann C, Young AR, Wittern KP, Bergemann J (2001) Induction of mRNA for matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 in human skin in vio by solar simulated radiation. Photochem Photobiol 73:657–663

    Article  PubMed  CAS  Google Scholar 

  45. Lavker RM (1995) Cutaneous aging: chronologic versus photo-aging. In: Gilchrest BA (ed) Photodamage. Blackwell Science, Cambridge, Mass, pp 123–135

    Google Scholar 

  46. Leyden JJ, Lavker RM, Kaidbey K (1995) UVA — A more important factor in chronic photodamage than previously recognized. J Geriatr Dermatol 3(Suppl A):29–32

    Google Scholar 

  47. MacLean AB, Nicol LA, Hodgins MB (1990) Immunohistochemical localization of estrogen receptors in the vulva and vagina. J Reprod Med 35:1015–1016

    PubMed  CAS  Google Scholar 

  48. Malvy J, Guinot C, Preziosi P, Vaillant L, Tenenhaus M, Galan P, Hercberg S, Tschachler E (2000) Epidemiologic determinants of skin photo-aging: baseline data of the SU.VI.MAX. cohort. J Am Acad Dermatol 42:47–55

    Article  PubMed  CAS  Google Scholar 

  49. Miyachi Y (1995) Photoaging from an oxidative standpoint. J Dermatol Sci 9:79–86

    Article  PubMed  CAS  Google Scholar 

  50. Naru E, Suzuki T, Moriyama M, Inomata K, Havashi A, Arakane K, Kafi K (2005) Functional changes induced by chronic UVA irradiation to cultured human dermal fibroblasts. Br J Dermatol 153(Suppl 2):6–12

    Article  PubMed  CAS  Google Scholar 

  51. Ohnishi Y, Tajima S, Akiyama M, Ishibashi A, Kobayashi R, Horii I (2000) Expression of elastin-related proteins and matrix metalloproteinases in actinic elastosis of sun-damaged skin. Arch Dermatol Res 292:27–31

    Article  PubMed  CAS  Google Scholar 

  52. Oitto J, Fazio MJ, Olsen DR (1989) Molecular mechanisms of cutaneous ageing. JAAD 3(2): 614–622

    Google Scholar 

  53. Oumeish OY (1998) The global ozone crisis. Clin Dermatol 16:11–18

    Article  PubMed  CAS  Google Scholar 

  54. Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J (1997) Cancer incidence in five continents. Volume VII. IARC Scientific Publications No 143. International Agency for Research on Cancer, Lyon

    Google Scholar 

  55. Pelle E, Miranda EP, Fthenakis C, Mammone T, Marenus K, Maes D (2002) Cigarette smoke-induced lipid peroxidation in human skin and its inhibition by topically applied antioxidants. Skin Pharmacol Appl Skin Physiol 15:63–68

    PubMed  CAS  Google Scholar 

  56. Punnonen R, Vaajalahti P, Teisala K (1987) Local oestriol treatment improves the structure of elastic fibers in the skin of postmenopausal women. Ann Chir Gynaecol (Suppl) 202:39–41

    CAS  Google Scholar 

  57. Reuther T, Neugebauer O, Kemper M, Williams S, Kerscher M (2005) Einfluss von Zigaretten-Nebenstromqualm auf den pH-Wert der Hautoberfläche. JDDG 3 (Suppl 1): S228

    Google Scholar 

  58. Rhie G, Shin MH, Seo JY, Choi WW, Cho KH, Kim KH, Park KC, Eun HC, Chung JH (2002) Aging-and photo-aging-dependent changes of enzymatic and nonenzymatic antioxidants in the epidermis and dermis of human skin in vivo. J Invest Dermatol 118:1212–1217

    Google Scholar 

  59. Saijo S, Hashimoto-Kumasaka K, Takahashi M, Tagami H (1991) Functional changes of the stratum corneum associated with aging and photo-aging. J Soc Cosmet Chem 42:379–383

    Google Scholar 

  60. Sander CS, Chang H, Salzmann S, Müller CS, Ekanayake-Mudiyans S, Elsner P, Thiele JJ (2002) Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol 118:618–625

    Article  PubMed  CAS  Google Scholar 

  61. Sander CS, Sercu S, Ziemer M, Hipler UC, Elsner P, Thiele JJ, Merregaert J (2006) Expression of extracellular matrix protein 1 (ECM1) in human skin in decreased by age and inreased upon ultraviolet exposure. Br J Dermatol 154: 218–224

    Article  PubMed  CAS  Google Scholar 

  62. Sator PG, Schmidt JB, Sator MO, Huber JC, Honigsmann H (2001) The influence of hormone replacement therapy on skin ageing: a pilot study. Maturitas 39:43–55

    Article  PubMed  CAS  Google Scholar 

  63. Schallreuter KU, Tobin DJ, Panske A (2002) Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo. Dermatology 204:194–201

    Article  PubMed  CAS  Google Scholar 

  64. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J (1997) UV-Induced Reactive Oxygen Species in Photocarcinogenesis and Photoaging. Biol Chem 1997 378:1247–1257

    PubMed  CAS  Google Scholar 

  65. Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A (1996) Treatment of skin aging with topical-estrogens. Int J Dermatol 35:669–674

    Article  PubMed  CAS  Google Scholar 

  66. Schwartz E, Druickshank FA, Christensen CC, Perlish JS, Lebwohl M (1993) Collagen alterations in chronically sun-damaged human skin. Photochem Photobiol 58:841–844

    Article  PubMed  CAS  Google Scholar 

  67. Shindo Y, Witt E, Han D, Epstein W, Packer L (1994) Enzymatic and non-enzymatic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 102:122–124

    Article  PubMed  CAS  Google Scholar 

  68. Soriani M, Hejmadi V, Tyrrell RM (2000) Modulation of c-jun and c-fos Transcription by UVB and UVA Radiations in Human Dermal Fibroblasts and KB Cells. Photochem Photobiol 71(5):551–558

    Article  PubMed  CAS  Google Scholar 

  69. Trautinger F, Mazzucco K, Knobler R, Trenz A, Kokoschka EM (1994) UVA-and UVB-induced changes in hairless mouse skin collagen. Arch Dermatol Res 286:490–494

    Article  PubMed  CAS  Google Scholar 

  70. Tyrrell R (1999) Redox regulation and oxidant activation of heme oxygenase-1. Free Radic Res 31:335–340

    Article  PubMed  CAS  Google Scholar 

  71. Uitto J (1997) Unterstanding premature skin aging. N Engl J Med, 337:1463–1465

    Article  PubMed  CAS  Google Scholar 

  72. Uitto J, Fazio MJ, Olsen DR (1998) Molecular mechanism of cutaneous aging. J Am Acad Dermatol 21:614–622

    Article  Google Scholar 

  73. Verdier-Sévrain S, Bonté F, Glichrest B (2006) Biology of estrogens in skin: implications for skin aging. Exp Dermatol 15:83–94

    Article  PubMed  CAS  Google Scholar 

  74. Wlaschek M, Tantcheva-Poor I, Naderi L, Ma W, Schneider LA, Razi-Wolf Z, Schuller J, Scharfetter-Kochanek K (2001) Solar UV irradiation and dermal photo-aging. J Photochem Photobiol B 63:41–51

    Article  PubMed  CAS  Google Scholar 

  75. Yin L, Morita A, Tsuji T (2000) Alterations of extracellular matrix induced by tobacco smoke extract. Arch Dermatol Res 292:188–194

    Article  PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Steinkopff Verlag

About this chapter

Cite this chapter

(2009). Die Hautalterung: Intrinsische und extrinsische Faktoren. In: Dermatokosmetik. Steinkopff. https://doi.org/10.1007/978-3-7985-1739-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-7985-1739-4_2

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1546-8

  • Online ISBN: 978-3-7985-1739-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics