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Aspects of gene expression in B cell lymphomas

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Microarrays in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Gene expression profiling has been used extensively for the analysis of human lymphomas. Besides the analysis of whole tissue or blood samples, genechip studies have also been applied to lymphoma cells isolated by cell sorting from cell suspensions or by laser microdissection from tissue sections. Such studies were successfully applied to clarify the cellular origin of lymphomas by comparison to normal B cell subsets, to gain insights into pathogenetic mechanisms, to develop molecular classifiers for differential diagnosis, to identify so far unrecognized subgroups among current lymphoma entities, and to establish predictors of prognosis. In our own work, we initially studied gene expression of Hodgkin lymphoma cell lines and revealed, for example, a global downregulation of the B cell gene expression programme and an aberrant expression of multiple receptor tyrosine kinases in these cells. We are now studying gene expression profiles from microdissected tumour cells of Hodgkin lymphoma.

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Author information

Authors and Affiliations

  1. Institute for Cell Biology (Tumor Research), Medical School, University of Duisburg-Essen, 45122, Essen, Germany

    Enrico Tiacci, Verena Brune & Ralf Küppers

  2. Institute of Pathology, University of Frankfurt/Main, 60590, Frankfurt, Germany

    Verena Brune

Authors
  1. Enrico Tiacci
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  2. Verena Brune
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  3. Ralf Küppers
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Editors and Affiliations

  1. Research & Development, Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Andreas Bosio

  2. Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch, Gladbach, Germany

    Bernhard Gerstmayer

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Tiacci, E., Brune, V., Küppers, R. (2008). Aspects of gene expression in B cell lymphomas. In: Bosio, A., Gerstmayer, B. (eds) Microarrays in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8334-3_12

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