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Role of IL-1 in erosive arthritis, lessons from animal models

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New Therapeutic Targets in Rheumatoid Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Tumor necrosis factor (TNF), interleukin-1 (IL-1) and IL-6 are considered master cytokines in chronic destructive arthritis. IL-1 drives chronic erosive arthritis and its blockade has been shown to ameliorate joint destruction in many animal models of arthritis. This ranges from a dominant role of IL-1 in immune complex arthritis, to a key role in development of T cell-dependent arthritis and TNF transgenic arthritis. This makes IL-1 an attractive therapeutic target, in addition to TNF and IL-6. However, IL-1 dependency can be lost under conditions of T cell IL-17 abundance as well as the presence of Toll-like receptor ligands. The latter may underlie the variable responsiveness of rheumatoid arthritis patients to anti-cytokine therapy and warrants combination therapy for optimal control.

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Authors and Affiliations

  1. Rheumatology Research & Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands

    Wim B. van den Berg, Leo A. B. Joosten & Fons A. J. van de Loo

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  1. Wim B. van den Berg
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  2. Leo A. B. Joosten
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  3. Fons A. J. van de Loo
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Editors and Affiliations

  1. Division of Clinical Immunology and Rheumatology EULAR & FOCIS Center of Excellence Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-218, 1105, AZ Amsterdam, The Netherlands

    Paul-Peter Tak

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van den Berg, W.B., Joosten, L.A.B., van de Loo, F.A.J. (2009). Role of IL-1 in erosive arthritis, lessons from animal models. In: Tak, PP. (eds) New Therapeutic Targets in Rheumatoid Arthritis. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8238-4_4

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  • DOI: https://doi.org/10.1007/978-3-7643-8238-4_4

  • Publisher Name: Birkhäuser Basel

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