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The role of glycine in pain and spasticity

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Spinal Cord Monitoring

Abstract

Neuropathic pain is an intense pain perceived without an obvious noxious stimulus. Spasticity is heightened stretch reflexes and excessive muscle tonus. Both are a common and severely debilitating sequela to injury of the nervous system and both conditions frequently occur together simultaneously. In order to support this glycine-based theory we tested the primary hypothesis with the assumption that a relationship exists between segmentai glycine levels and neuropathic pain and spasticity. These tests included: 1) the detection of segmentai glycine release after motor and sensory pathway stimulation in normal injured animals, 2) the reduction of pain and spasticity following administration of glycine, and its receptor agonists, and 3) the production of pain and spasticity following administration of glycine receptor antagonists. Once fulfilled, results from these experiments would support the goal directed toward enhancing glycine receptor mechanisms as treatment for neuropathic pain and spasticity. Two animal models were employed to test the hypothesis, 1) a classic model of neuropathic pain in the rat created by sciatic nerve constriction, and 2) an established model of spasticity in the rabbit created by spinal cord ischemia.

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Authors and Affiliations

  1. Departments of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA

    R. K. Simpson Jr. & C. S. Robertson

  2. Departments of Pathology, Baylor College of Medicine, Houston, Texas, USA

    J. Clay Goodman

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  1. R. K. Simpson Jr.
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  2. C. S. Robertson
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  3. J. Clay Goodman
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Editors and Affiliations

  1. Department of Clinical Neurophysiology, University Hospital, Uppsala University, Uppsala, Sweden

    Erik Stålberg M.D.

  2. Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden

    Hari Shanker Sharma Ph.D.

  3. Laboratory of Neuropathology, Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

    Yngve Olsson M.D.

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© 1998 Springer-Verlag Wien

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Simpson, R.K., Robertson, C.S., Goodman, J.C. (1998). The role of glycine in pain and spasticity. In: Stålberg, E., Sharma, H.S., Olsson, Y. (eds) Spinal Cord Monitoring. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6464-8_4

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  • DOI: https://doi.org/10.1007/978-3-7091-6464-8_4

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  • Print ISBN: 978-3-7091-7329-9

  • Online ISBN: 978-3-7091-6464-8

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