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Cytoprotective Role of Haptoglobin in Brain After Experimental Intracerebral Hemorrhage

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Intracerebral Hemorrhage Research

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

After intracerebral hemorrhage (ICH), hemoglobin (Hb) that is released from erythrocytes within the brain hematoma is highly cytotoxic and leads to severe brain edema and direct neuronal damage. Therefore, neutralization of Hb could represent an important target for reducing the secondary injury after ICH. Haptoglobin (Hp), an endogenous Hb-binding protein in blood plasma, is found in this study to be upregulated in the hematoma-affected brain after ICH. Both in vivo and in vitro studies indicate that Hp upregulation is primarily mediated by oligodendrocytes. Hp acts as a secretory protein capable of neutralizing the cell-free Hb. We also found in an “ICH-like” injury that Hp-KO mice show the most severe brain injury and neurological deficits, whereas Hp-Tg mice are the most resistant to ICH injury, suggesting that a higher Hp level is associated with the increased resistance of animals to hemolytic product-mediated brain injury after ICH. We conclude that brain-derived Hp plays a cytoprotective role after ICH, and Hp may represent a new potential therapeutic target for management of ICH.

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Acknowledgements

This study was supported in part by NIH/NINDS projects RO1NS060768, R21NS057284 and RO1NS064109. We thank Drs. Franklin G. Berger and Karen Barbour (University of South Carolina, Columbia, SC), who kindly provided us the Hp-Tg and Hp-KO mice.

Conflict of interest statement We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Stroke Program – Department of Neurology, University of Texas Health Science Center, Medical School at Houston, Houston, TX, 77030, USA

    Xiurong Zhao, Shen Song, Guanghua Sun, Jie Zhang, Roger Strong, Lihua Zhang, James C. Grotta & Jaroslaw Aronowski

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  1. Xiurong Zhao
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  2. Shen Song
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  3. Guanghua Sun
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  4. Jie Zhang
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  5. Roger Strong
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  6. Lihua Zhang
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  7. James C. Grotta
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  8. Jaroslaw Aronowski
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Correspondence to Jaroslaw Aronowski .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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Zhao, X. et al. (2011). Cytoprotective Role of Haptoglobin in Brain After Experimental Intracerebral Hemorrhage. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_17

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_17

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0692-1

  • Online ISBN: 978-3-7091-0693-8

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