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Blood-brain barrier function in intracerebral hemorrhage

  • Conference paper
Cerebral Hemorrhage

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 105))

Abstract

In this paper, we review current knowledge on blood-brain barrier (BBB) dysfunction following intracerebral hemorrhage (ICH). BBB disruption is a hallmark of ICH-induced brain injury. Such disruption contributes to edema formation, the influx of leukocytes, and the entry of potentially neuroactive agents into the perihematomal brain, all of which may contribute to brain injury. A range of factors have been implicated in inducing BBB disruption, including inflammatory mediators (e.g., cytokines and chemokines), thrombin, hemoglobin breakdown products, oxidative stress, complement, and matrix metalloproteinases. While there is interaction between some of these mediators, it is probable that prevention of ICH-induced BBB disruption will involve blocking multiple pathways or blocking a common end pathway (e.g., by stabilizing tight junction structure). While the effects of ICH on BBB passive permeability have been extensively examined, effects on other ‘barrier’ properties (metabolic and transport functions) have been less well-studied. However, recent data suggests that ICH can affect transport and that this may help protect the BBB and the brain. Indeed, it is possible in small bleeds that BBB disruption may be beneficial, and it is only in the presence of larger bleeds that disruption has detrimental effects.

Dr. Julian T. Hoff died prior to publication of this article.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan Medical School, Room 5018, BSRB, Ann Arbor, MI, 48109-2200, USA

    R. F. Keep Ph.D., J. Xiang, S. R. Ennis, A. Andjelkovic, Y. Hua, G. Xi & J. T. Hoff

  2. Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA

    R. F. Keep Ph.D.

  3. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    A. Andjelkovic

Authors
  1. R. F. Keep Ph.D.
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  2. J. Xiang
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  3. S. R. Ennis
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  4. A. Andjelkovic
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  5. Y. Hua
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  6. G. Xi
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  7. J. T. Hoff
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Huashan Hospital, Fudan University, Shanghai, China

    Liang-Fu Zhou , Xian-Cheng Chen  & Feng-Ping Huang ,  & 

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Guohua Xi , Richard F. Keep , Ya Hua  & Karin Muraszko , ,  & 

  3. Department of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China

    Yi-Cheng Lu

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© 2008 Springer-Verlag

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Keep, R.F. et al. (2008). Blood-brain barrier function in intracerebral hemorrhage. In: Zhou, LF., et al. Cerebral Hemorrhage. Acta Neurochirurgica Supplementum, vol 105. Springer, Vienna. https://doi.org/10.1007/978-3-211-09469-3_15

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  • DOI: https://doi.org/10.1007/978-3-211-09469-3_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-09468-6

  • Online ISBN: 978-3-211-09469-3

  • eBook Packages: MedicineMedicine (R0)

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