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Comparison of Intrathecal Cilostazol and Nimodipine Treatments in Subarachnoid Hemorrhage: An Experimental Study in Rabbits

  • Conference paper
Early Brain Injury or Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 110/2))

Abstract

Objective: Intrathecal administration of calcium channel antagonists has been proposed to reduce cerebral vasospasm (CVS) in animal subarachnoid hemorrhage (SAH) models. Also, delayed CVS treatment model with oral administration of cilostazol can be seen in the literature.

Methods: In this study, 25 male New Zealand white rabbits were randomly assigned to five groups: control, SAH only, SAH/nimodipine, SAH/cilostazol, SAH/vehicle. The animals’ basilar arteries were sectioned from four separate zones and four sections were obtained from each rabbit. Basilar artery luminal section areas were measured by using SPOT for windows Version 4.1 computer program.

Results: Basilar artery luminal section areas in SAH/ nimodipine and SAH/ cilostazol groups were significantly higher than SAH only group (P < 0.05).

Conclusion: Phosphodiesterase 3 inhibitor cilostazol has vasodilatory effects without affecting cerebral blood flow. Nimodipine is a calcium channel blocker and is still used in vasospasm therapy either oral or intravenously. This study demonstrates that prophylactic bolus intrathecal administration of either cilostazol or nimodipine equally prevents SAH-associated CVS in an animal model. We therefore propose that cilostazol is a candidate for clinical trials in the treatment of delayed vasospasm.

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Acknowledgement

This study was founded by Turkish Neurosurgery Society.

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Authors and Affiliations

  1. Department of Neurosurgery, Hacettepe University School of Medicine, Ugur Mumcunun Sokak, 78/2, 06700, Gaziosmanpasa, Ankara, Turkey

    Mehmet Bulent Onal, Burcak Bilginer, Firat Narin, M. İbrahim Ziyal & Tuncalp Ozgen

  2. Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey

    Figen Soylemezoglu

Authors
  1. Mehmet Bulent Onal
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  2. Burcak Bilginer
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  4. M. İbrahim Ziyal
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  5. Figen Soylemezoglu
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  6. Tuncalp Ozgen
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Correspondence to Mehmet Bulent Onal .

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Editors and Affiliations

  1. Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Gaotanyan 30, Chongqing, 400038, China

    Hua Feng

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Ying Mao

  3. Departments of Physiology and Neurosurgery, Loma Linda University School of Medicine, Risley Hall, Room 223, 92354, Loma Linda, California, USA

    John H. Zhang

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Onal, M.B., Bilginer, B., Narin, F., Ziyal, M.İ., Soylemezoglu, F., Ozgen, T. (2011). Comparison of Intrathecal Cilostazol and Nimodipine Treatments in Subarachnoid Hemorrhage: An Experimental Study in Rabbits. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_9

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  • DOI: https://doi.org/10.1007/978-3-7091-0356-2_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0355-5

  • Online ISBN: 978-3-7091-0356-2

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