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Continuous Intra-Arterial Nimodipine for the Treatment of Cerebral Vasospasm

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Abstract

Two patients with refractory symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) were treated by continuous intra-arterial nimodipine infusion via a catheter placed in the internal carotid artery or vertebral artery for 3 and 12 days, respectively. Recovery of the neurological deficits, normalization of MR perfusion, a decrease in the elevated mean flow velocity measured by transcranial duplex sonography, and angiographic recanalization were observed. Continuous intra-arterial nimodipine might be a treatment option in severe refractory vasospasm following SAH.

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Authors and Affiliations

  1. Department of Neuroradiology, University Hospital, Friedrich-Schiller-University Jena (FSU), Erlanger Allee 101, Jena, 07747, Germany

    Thomas E. Mayer

  2. Department of Neurology, Klinikum Grosshadern, University of Munich (LMU), Marchioninistr. 15, München, 81377, Germany

    Martin Dichgans, Andreas Straube & Tobias Birnbaum

  3. Department of Neuroradiology, Klinikum Grosshadern, University of Munich (LMU), Marchioninistr. 15, München, 81377, Germany

    Stephanie Müller-Schunk

  4. Department of Neurology, Dr. Horst Schmidt Klinik, Wiesbaden, Ludwig Erhard Str. 100, Wiesbaden, 65199, Germany

    Gerhard F. Hamann

  5. Department of Radiology, University Hospital, Universitätsstraße 150, Bochum, 44801, Germany

    Gernot Schulte-Altedorneburg

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  1. Thomas E. Mayer
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  2. Martin Dichgans
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  3. Andreas Straube
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  4. Tobias Birnbaum
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  5. Stephanie Müller-Schunk
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  6. Gerhard F. Hamann
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  7. Gernot Schulte-Altedorneburg
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Correspondence to Thomas E. Mayer.

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Mayer, T.E., Dichgans, M., Straube, A. et al. Continuous Intra-Arterial Nimodipine for the Treatment of Cerebral Vasospasm. Cardiovasc Intervent Radiol 31, 1200–1204 (2008). https://doi.org/10.1007/s00270-008-9346-0

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  • DOI: https://doi.org/10.1007/s00270-008-9346-0

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