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NO and ART

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Artemisinin and Nitric Oxide

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

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Abstract

NO, mainly synthesized by NOS, is a signal transducer that conveys internal and external stimulations. The isoform of eNOS/nNOS is responsible for stable NO production, while the isoform of iNOS can be induced by proinflammatory cytokines for NO burst. Bacteria also synthesize NO by their own bNOS. ART exerts distinct roles in a dose-dependent manner. Low-dose ART induces and activates eNOS/nNOS, whereas high-dose ART inactivates all isoforms of NOS. ART can also mimic NO to upregulate COX for evoking mitochondrial uncoupling and biogenesis.

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  1. Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, China

    Qing-Ping Zeng

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Zeng, QP. (2015). NO and ART. In: Artemisinin and Nitric Oxide. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47688-8_2

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