Abstract
Protein S-nitrosylation is a type of posttranslational modification that changes protein stability, intracellular localization, and biological activity. In mammalian cells, NO is synthesized by NOS which is highly expressed in many solid tumors, including breast cancer. NOS is involved in the progress of carcinogenesis by generating NO to modify various tumor-related proteins to enhance or suppress their function. However, the effect of NO on tumor metastasis is less studied. Herein, breast cancer cells MCF-7 and MDA-MB-231 were treated with NO donor SNP, which resulted in altered cell mobility. Meanwhile the expression of several metastasis-related genes was regulated. These results suggest a novel mechanism by which NO promotes the metastasis of breast cancer.
J. Hu and H. He—Co-first authors.
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Acknowledgments
We thank Professor Zhonghua Pang from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College for providing MDA-MB-231 cell line. This work was supported by the National Natural Science Foundation of China (31301073) and Applied Basic Science and Frontier Technology Program of Tianjin (13JCYBJC38000).
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Hu, J. et al. (2015). SNP Affects the Mobility of Breast Cancer Cells and the Expression of Metastasis-Related Genes. In: Zhang, TC., Nakajima, M. (eds) Advances in Applied Biotechnology. Lecture Notes in Electrical Engineering, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46318-5_20
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DOI: https://doi.org/10.1007/978-3-662-46318-5_20
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