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Mitochondrial and Vacuolar ATPases

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Biochemistry and Molecular Biology

Part of the book series: The Mycota ((MYCOTA,volume 3))

Abstract

Mitochondrial and vacuolar ATPases, often referred to as F-type and V-type ATPases, respectively, are among the most complex enzymes of the cell. Many structural features are shared by both types. They are particularly large enzymes comprised of as many as 14 different types of subunits having aggregate molecular weights of 500–800kDa. Each enzyme can be separated into two structural entities, a membrane sector called F0 or V0 and a water-soluble peripheral sector called F1 or V1. The two types of ATPases also share a common evolutionary origin (disscussed below). However, in their current roles in the cell, they have diverged functionally. The mitochondrizl ATPase serves as the primary producer of ATP in the cell, while the vacuolar ATPase is an zvid consumer of ATP, using the energy derived from ATP hydrolysis to drive a variety of cellular processes.

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  1. Department of Biology, University of California, Santa Cruz, CA, 95064, USA

    B. J. Bowman & E. J. Bowman

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  1. Department of Plant Biology, University of Minnesota, 220 Biological Sciences Center, 55108, Saint Paul, MN, USA

    Robert Brambl

  2. Department of Biochemistry, Ohio State University, 484 West 12th Avenue, 43210-1292, Columbus, OH, USA

    George A. Marzluf

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Bowman, B.J., Bowman, E.J. (1996). Mitochondrial and Vacuolar ATPases. In: Brambl, R., Marzluf, G.A. (eds) Biochemistry and Molecular Biology. The Mycota, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10367-8_3

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  • DOI: https://doi.org/10.1007/978-3-662-10367-8_3

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